The concentrations of β-endorphin and cholecystokinin were measured in fresh resting peripheral mononuclear cells obtained from rats and human subjects in basal conditions and after different pharmacological treatments. Both in the human and the rat, β-endorphin concentrations in mononuclear cells increased after treatment with serotoninergic agonists, decreased after dopaminergic or GABAergic drugs, while the respective antagonists exerted the opposite effect. In vitro, serotoninergic and GABAergic compounds confirmed their roles in the modulation of β-endorphin in mononuclear cells. Cholecystokinin was never affected by the pharmacological treatments.
Pharmacological modulation of neuropeptides in peripheral mononuclear cells / P.SACERDOTE,F.RUBBOLI,L.LOCATELLI,I.CICILIATO,P.MANTEGAZZA, A.E.PANERAI. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 32:1(1991), pp. 35-41.
Pharmacological modulation of neuropeptides in peripheral mononuclear cells
P.SACERDOTEPrimo
;A.E.PANERAIUltimo
1991
Abstract
The concentrations of β-endorphin and cholecystokinin were measured in fresh resting peripheral mononuclear cells obtained from rats and human subjects in basal conditions and after different pharmacological treatments. Both in the human and the rat, β-endorphin concentrations in mononuclear cells increased after treatment with serotoninergic agonists, decreased after dopaminergic or GABAergic drugs, while the respective antagonists exerted the opposite effect. In vitro, serotoninergic and GABAergic compounds confirmed their roles in the modulation of β-endorphin in mononuclear cells. Cholecystokinin was never affected by the pharmacological treatments.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
