Now progressive systemic sclerosis (PSS) is considered a disease of small vessels with which many immunologic alterations are associated. The presence in the blood of large amounts of serotonin can be considered a very important aggravating factor able to cause the sclerodermic alterations. The authors have treated 10 PSS patients with ketanserin, a selective antagonist of the S2 serotonin receptors, which are found in small vessels and platelets. Their results show that ketanserin represents an efficacious and very well tolerated therapy for treatment of the initial vascular symptoms of PSS.

Ketanserin in the treatment of progressive systemic sclerosis / G.F. Altomare, P.D. Pigatto, M.M. Polenghi. - In: ANGIOLOGY. - ISSN 0003-3197. - 39:7 Pt 1(1988 Jul), pp. 583-586. [10.1177/000331978803900705]

Ketanserin in the treatment of progressive systemic sclerosis

G.F. Altomare
Primo
;
P.D. Pigatto
Secondo
;
1988

Abstract

Now progressive systemic sclerosis (PSS) is considered a disease of small vessels with which many immunologic alterations are associated. The presence in the blood of large amounts of serotonin can be considered a very important aggravating factor able to cause the sclerodermic alterations. The authors have treated 10 PSS patients with ketanserin, a selective antagonist of the S2 serotonin receptors, which are found in small vessels and platelets. Their results show that ketanserin represents an efficacious and very well tolerated therapy for treatment of the initial vascular symptoms of PSS.
Fingers; Raynaud Disease; Humans; Adult; Scleroderma, Systemic; Middle Aged; Ketanserin; Skin Ulcer; Regional Blood Flow; Female
Settore MED/35 - Malattie Cutanee e Veneree
lug-1988
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/194892
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