A numerical study of the energy landscape of the space of model protein sequences is carried out. As a consequence of the heterogeneity of the contact energies among amino acids, the energy landscape displays a very rough profile, a behaviour typical of frustrated systems. This gives raise to a hierarchical clustering of low-energy sequences and can have evolutionary consequences.
Energy Profile of the Space of Model Protein Sequences / G. Tiana, R. A. Broglia , E. I. Shakhnovich. - In: JOURNAL OF BIOLOGICAL PHYSICS. - ISSN 0092-0606. - 27:2-3(2001), pp. 147-159.
Energy Profile of the Space of Model Protein Sequences
G. TianaPrimo
;
2001
Abstract
A numerical study of the energy landscape of the space of model protein sequences is carried out. As a consequence of the heterogeneity of the contact energies among amino acids, the energy landscape displays a very rough profile, a behaviour typical of frustrated systems. This gives raise to a hierarchical clustering of low-energy sequences and can have evolutionary consequences.
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