The major goal of our research is the development of synthetically useful selective biotransformations using microbial enzymes by combining natural and non-natural conditions. Biotransformations to be used in pharmaceutical manufacturing has been studied. Examples from our work will be presented with regards to these strategies, including different applications: ➢ Selective modification (deacylation and demannosilation) of lipoglycopeptide antibiotics by using hydrolases from actinomycetes. Case study: modification of ramoplanin ➢ Chemo- and enantioselective oxidations for the production of optically pure intermediates to be used for the synthesis of different drugs. Case study: chemoenzymatic synthesis of Captopril® Different techniques have been exploited for improving the selectivity and/or productivity of the bioprocesses: reaction engineering, biocatalyst manipulation and reactor engineering.
Biocatalysis for the manufacture of pharma intermediates / F. Molinari. ((Intervento presentato al convegno Chimica Organica e Biotecnologie: Sfide e Opportunità tenutosi a Forte dei Marmi nel 2009.
Biocatalysis for the manufacture of pharma intermediates
F. MolinariPrimo
2009
Abstract
The major goal of our research is the development of synthetically useful selective biotransformations using microbial enzymes by combining natural and non-natural conditions. Biotransformations to be used in pharmaceutical manufacturing has been studied. Examples from our work will be presented with regards to these strategies, including different applications: ➢ Selective modification (deacylation and demannosilation) of lipoglycopeptide antibiotics by using hydrolases from actinomycetes. Case study: modification of ramoplanin ➢ Chemo- and enantioselective oxidations for the production of optically pure intermediates to be used for the synthesis of different drugs. Case study: chemoenzymatic synthesis of Captopril® Different techniques have been exploited for improving the selectivity and/or productivity of the bioprocesses: reaction engineering, biocatalyst manipulation and reactor engineering.Pubblicazioni consigliate
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