C1-inhibitor is an acid glycoprotein, isoelectric point 3.5-3.6. Plasma of some patients with a variant form of hereditary angioedema contains high levels of functionless C1-inhibitor-albumin complex with an isoelectric point at 4.5-4.6. Therapy with Danazol, which increases C1-inhibitor levels, does not modify the isoelectric focusing pattern of such protein in patients with hereditary angioedema.
Immunoreactive precipitation of C1 inhibitor protein from plasma of normalsubjects and of patients with hereditary angioedema after isoelectric focusing / L.C. Bergamaschini, C. Valle, M. Franzinelli, M. Cicardi, A. Agostoni. - In: JOURNAL OF CLINICAL CHEMISTRY AND CLINICAL BIOCHEMISTRY. - ISSN 0340-076X. - 24:10(1986), pp. 719-722.
Immunoreactive precipitation of C1 inhibitor protein from plasma of normalsubjects and of patients with hereditary angioedema after isoelectric focusing
L.C. BergamaschiniPrimo
;M. CicardiPenultimo
;A. AgostoniUltimo
1986
Abstract
C1-inhibitor is an acid glycoprotein, isoelectric point 3.5-3.6. Plasma of some patients with a variant form of hereditary angioedema contains high levels of functionless C1-inhibitor-albumin complex with an isoelectric point at 4.5-4.6. Therapy with Danazol, which increases C1-inhibitor levels, does not modify the isoelectric focusing pattern of such protein in patients with hereditary angioedema.
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