DNA polymerase alpha (pol alpha) holds a special position among the growing family of eukaryotic DNA polymerases. In fact, pol alpha is associated with DNA primase to form a four subunit complex and, as a consequence, is the only enzyme able to start DNA synthesis de novo. Because of this peculiarity the major role of the DNA polymerase alpha-primase complex (pol-prim) is in the initiation of DNA replication at chromosomal origins and in the discontinuous synthesis of Okazaki fragments on the lagging strand of the replication fork. However, pol-prim seems to play additional roles in other complex cellular processes, such as the response to DNA damage, telomere maintenance, and the epigenetic control of higher order chromatin assembly.
The DNA polymerase alpha-primase complex: multiple functions and interactions / M. Muzi Falconi, M. Giannattasio, M. Foiani, P. Plevani. - In: THE SCIENTIFIC WORLD JOURNAL. - ISSN 1537-744X. - 3:(2003 Mar 17), pp. 21-33-33. [10.1100/tsw.2003.05]
The DNA polymerase alpha-primase complex: multiple functions and interactions
M. Muzi Falconi;M. Giannattasio;M. FoianiPenultimo
;
2003
Abstract
DNA polymerase alpha (pol alpha) holds a special position among the growing family of eukaryotic DNA polymerases. In fact, pol alpha is associated with DNA primase to form a four subunit complex and, as a consequence, is the only enzyme able to start DNA synthesis de novo. Because of this peculiarity the major role of the DNA polymerase alpha-primase complex (pol-prim) is in the initiation of DNA replication at chromosomal origins and in the discontinuous synthesis of Okazaki fragments on the lagging strand of the replication fork. However, pol-prim seems to play additional roles in other complex cellular processes, such as the response to DNA damage, telomere maintenance, and the epigenetic control of higher order chromatin assembly.Pubblicazioni consigliate
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