The levels of atherogenic lipid fractions are higher in children with a family history of ischemic cardiovascular disease (CD). This study was designed to examine this relationship in neonates. A total of 1276 newborns were investigated; 400 cord blood samples were collected for measurement of triglycerides (TG), total cholesterol (TC), LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C); on day 4, 1200 capillary samples were taken for TC and TG measurements. Male newborns with a positive history of CD had higher concentrations of cord blood TC (P less than 0.04) and LDL-C (P less than 0.02). On day 4 this difference in TC was no longer detectable (LDL-C not determined). A coronary heart disease (CHD) risk factor family history is sensitive (0.87) in predicting high cord blood concentrations of LDL-C, the specificity being 0.46 and the positive predicting value 0.08.

Familial history of cardiovascular disease and blood lipid pattern in newborn infants / R. Bellù, M.T. Ortisi, C. Agostoni, P. Incerti, R. Besana, E. Riva, M. Giovannini. - In: ACTA PAEDIATRICA. - ISSN 0803-5253. - 81:1(1992 Jan), pp. 21-24.

Familial history of cardiovascular disease and blood lipid pattern in newborn infants

C. Agostoni;E. Riva
Penultimo
;
M. Giovannini
Ultimo
1992

Abstract

The levels of atherogenic lipid fractions are higher in children with a family history of ischemic cardiovascular disease (CD). This study was designed to examine this relationship in neonates. A total of 1276 newborns were investigated; 400 cord blood samples were collected for measurement of triglycerides (TG), total cholesterol (TC), LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C); on day 4, 1200 capillary samples were taken for TC and TG measurements. Male newborns with a positive history of CD had higher concentrations of cord blood TC (P less than 0.04) and LDL-C (P less than 0.02). On day 4 this difference in TC was no longer detectable (LDL-C not determined). A coronary heart disease (CHD) risk factor family history is sensitive (0.87) in predicting high cord blood concentrations of LDL-C, the specificity being 0.46 and the positive predicting value 0.08.
cholesterol screening; cord blood lipids; neonates; risk of cardiovascular disease
Settore MED/38 - Pediatria Generale e Specialistica
gen-1992
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/190970
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