A 60-year-old man affected by nonhealing midline granuloma (NHmG) is described. The histopathological features, the clinical course and the radiosensitivity of the lesion clearly differentiate this pathological condition from malignant lymphomas and from Wegener's granulomatosis (WG). The presence of antinuclear antibodies with an antinucleolar pattern in a subject bearing HLA-B8 suggests the involvement of autoimmune phenomena and a close relation between NHmG and WG.
Immunological features of nonhealing midline granuloma / M. Galli, A. Formenti, C. Pettenati, G. De Bartolo, C. Mariscotti, S. Ponzi. - In: ORL. - ISSN 0301-1569. - 48:5(1986), pp. 256-260. [10.1159/000275878]
Immunological features of nonhealing midline granuloma
M. Galli;
1986
Abstract
A 60-year-old man affected by nonhealing midline granuloma (NHmG) is described. The histopathological features, the clinical course and the radiosensitivity of the lesion clearly differentiate this pathological condition from malignant lymphomas and from Wegener's granulomatosis (WG). The presence of antinuclear antibodies with an antinucleolar pattern in a subject bearing HLA-B8 suggests the involvement of autoimmune phenomena and a close relation between NHmG and WG.
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