This viewpoint proposes that an imbalance in the T(H)1-type and T(H)2-type responses contributes to the immune dysregulation associated with HIV infection, and that resistance to HIV infection and/or progression to AIDS is dependent on a T(H)1 > T(H)2 dominance. This hypothesis is based on the authors' findings that: (1) progression to AIDS is characterized by loss of IL-2- and IFN-gamma production concomitant with increases in IL-4 and IL-10; and (2) many seronegative, HIV-exposed individuals generate strong T(H)1-type responses to HIV antigens.
A TH1-->TH2 switch is a critical step in the etiology of HIV infection / M. Clerici, G.M. Shearer. - In: IMMUNOLOGY TODAY. - ISSN 0167-5699. - 14:3(1993), pp. 107-110.
A TH1-->TH2 switch is a critical step in the etiology of HIV infection
M. ClericiPrimo
;
1993
Abstract
This viewpoint proposes that an imbalance in the T(H)1-type and T(H)2-type responses contributes to the immune dysregulation associated with HIV infection, and that resistance to HIV infection and/or progression to AIDS is dependent on a T(H)1 > T(H)2 dominance. This hypothesis is based on the authors' findings that: (1) progression to AIDS is characterized by loss of IL-2- and IFN-gamma production concomitant with increases in IL-4 and IL-10; and (2) many seronegative, HIV-exposed individuals generate strong T(H)1-type responses to HIV antigens.Pubblicazioni consigliate
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