The development and validation, by experimental design, of an adsorptive stripping voltammetric procedure for nimesulide determination is described. A Plackett-Burman matrix and a Doehlert design were used for the screening step and response surface study, respectively. Response surface evaluation allowed the method to be defined robust and robustness testing was considered unnecessary. A full factorial design was employed for intermediate precision determination according to ICH guidelines. Applying the optimised conditions, the linear range was 3.32 x 10(-9)-3.85 x 10(-7) M and the dosage form mean recovery was 101.3% with RSD of 1.3% (n=9). (C) 2000 Elsevier Science B.V. All rights reserved.
Designing experiments to optimise and validate the adsorptive stripping voltammetric determination of nimesulide / S. Furlanetto, S. Orlandini, G. Aldini, R. Gotti, E. Dreassi, S. Pinzauti. - In: ANALYTICA CHIMICA ACTA. - ISSN 0003-2670. - 413:1-2(2000), pp. 229-239. [10.1016/S0003-2670(00)00735-2]
Designing experiments to optimise and validate the adsorptive stripping voltammetric determination of nimesulide
G. Aldini;
2000
Abstract
The development and validation, by experimental design, of an adsorptive stripping voltammetric procedure for nimesulide determination is described. A Plackett-Burman matrix and a Doehlert design were used for the screening step and response surface study, respectively. Response surface evaluation allowed the method to be defined robust and robustness testing was considered unnecessary. A full factorial design was employed for intermediate precision determination according to ICH guidelines. Applying the optimised conditions, the linear range was 3.32 x 10(-9)-3.85 x 10(-7) M and the dosage form mean recovery was 101.3% with RSD of 1.3% (n=9). (C) 2000 Elsevier Science B.V. All rights reserved.
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