Heparin-like tetrasaccharides 1-3, differing in their sulfation pattern at position 6 of the glucosamine units, were synthesised. The three compounds are putative ligands for fibroblast growth factors and have the unusual sequence (GlcN-IdoA). They were obtained from two common disaccharide precursors by a versatile synthetic procedure.
A rational approach to heparin-related fragments - Synthesis of differently sulfated tetrasaccharides as potential ligands for fibroblast growth factors / L. Poletti, M. Fleischer, C. Vogel, M. Guerrini, G. Torri, L. Lay. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - 14(2001), pp. 2727-2734. [10.1002/1099-0690(200107)2001:14<2727::AID-EJOC2727>3.0.CO;2-8]
A rational approach to heparin-related fragments - Synthesis of differently sulfated tetrasaccharides as potential ligands for fibroblast growth factors
L. PolettiPrimo
;L. Lay
2001
Abstract
Heparin-like tetrasaccharides 1-3, differing in their sulfation pattern at position 6 of the glucosamine units, were synthesised. The three compounds are putative ligands for fibroblast growth factors and have the unusual sequence (GlcN-IdoA). They were obtained from two common disaccharide precursors by a versatile synthetic procedure.
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