Ortho-aminobenzonitriles 1 react with beta-ketoesters and alkyl malonates, in the presence of stoichiometric amounts of tin(IV) chloride, to give 4-aminoquinolines 2 and 4-amino-2-quinolones 3 respectively. Similarly beta-enaminonitriles 7 afford 4-aminopyridines 8 and 4-amino-2-pyridones 9.
TIN(IV) CHLORIDE-PROMOTED SYNTHESIS OF 4-AMINOPYRIDINES AND 4-AMINOQUINOLINES / A. VERONESE, R. CALLEGARI, C. MORELLI. - In: TETRAHEDRON. - ISSN 0040-4020. - 51:45(1995), pp. 12277-12284.
TIN(IV) CHLORIDE-PROMOTED SYNTHESIS OF 4-AMINOPYRIDINES AND 4-AMINOQUINOLINES
C. MORELLIUltimo
1995
Abstract
Ortho-aminobenzonitriles 1 react with beta-ketoesters and alkyl malonates, in the presence of stoichiometric amounts of tin(IV) chloride, to give 4-aminoquinolines 2 and 4-amino-2-quinolones 3 respectively. Similarly beta-enaminonitriles 7 afford 4-aminopyridines 8 and 4-amino-2-pyridones 9.
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