We report a case of herpetic brainstem encephalitis (HBE) retrospectively diagnosed in an adult patient. Conventional immunovirological studies failed to disclose the etiology of this patient's affection. An isoelectric focusing-antigen overlay (IEF-O) technique showed that the target of one of the four cerebrospinal fluid oligoclonal bands was herpes simplex virus (HSV)-1 glycoprotein B, indicating a specific anti-HSV immunoresponse restricted to the CNS. IEF-O may represent a useful support for in vivo diagnosis of HBE.

Isoelectric focusing herpes simplex virus-gB overlay study in brainstem encephalitis / Martino GV, Grimaldi LM, Franciotta DM, Piccolo G, Brustia R, Minali L, Melzi d'Eril GV.. - In: ACTA NEUROLOGICA SCANDINAVICA. - ISSN 0001-6314. - 82:6(1990 Dec), pp. 364-367.

Isoelectric focusing herpes simplex virus-gB overlay study in brainstem encephalitis

Melzi d'Eril GV.
1990

Abstract

We report a case of herpetic brainstem encephalitis (HBE) retrospectively diagnosed in an adult patient. Conventional immunovirological studies failed to disclose the etiology of this patient's affection. An isoelectric focusing-antigen overlay (IEF-O) technique showed that the target of one of the four cerebrospinal fluid oligoclonal bands was herpes simplex virus (HSV)-1 glycoprotein B, indicating a specific anti-HSV immunoresponse restricted to the CNS. IEF-O may represent a useful support for in vivo diagnosis of HBE.
brainstem encephalitis; herpes simplex virus type 1; isoelectric focusing antigen overlay; oligoclonal bands
Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica
dic-1990
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/185432
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