This paper reviews some clinically relevant aspects of the epidemiology of ovarian cancer. The items presented and discussed are: (1) incidence and mortality data: they show substantial stability in all Western countries over the last few decades; (2) risk factors: the relationships with child-bearing patterns and other reproductive variables (age at menarche and at menopause; oral contraceptives) appear well established but no risk factor is sufficiently strong to be of practical value in prevention or early diagnosis: (3) long-term survival: in spite of the large number of clinical studies that have claimed 'more effective' treatments, no improvement of long-term survival in the population as a whole has been established. Some discrepancies and drawbacks in published trials are discussed, and a different approach towards clinical studies is suggested.
The clinical relevance of the epidemiology of ovarian cancer / C. La Vecchia, S. Franceschi, A. Liberati, G. Gallus, G. Tognoni. - In: EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY. - ISSN 0277-5379. - 20:2(1984 Feb), pp. 175-182. [10.1016/0277-5379(84)90181-0]
The clinical relevance of the epidemiology of ovarian cancer
C. La VecchiaPrimo
;
1984
Abstract
This paper reviews some clinically relevant aspects of the epidemiology of ovarian cancer. The items presented and discussed are: (1) incidence and mortality data: they show substantial stability in all Western countries over the last few decades; (2) risk factors: the relationships with child-bearing patterns and other reproductive variables (age at menarche and at menopause; oral contraceptives) appear well established but no risk factor is sufficiently strong to be of practical value in prevention or early diagnosis: (3) long-term survival: in spite of the large number of clinical studies that have claimed 'more effective' treatments, no improvement of long-term survival in the population as a whole has been established. Some discrepancies and drawbacks in published trials are discussed, and a different approach towards clinical studies is suggested.Pubblicazioni consigliate
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