The mechanism of Fe-induced peroxidation of arachidonic acid (AA) in small unilamellar vesicles (SUV) of dipalmitoylphosphatidylcholine (DPPC) and dipalmitoylphosphatidylethanolamine (DPPE) was studied below and above gel to liquid-crystalline phase transition temperature (Tm). In both liposomes the AA peroxidation resulted higher in the temperature range below Tm, but the extent of malonyldialdehyde (MDA) formation was dramatically lower in DPPE vesicles when compared with corresponding DPPC liposomes. A possible explanation for this is discussed.
STUDIES ON PEROXIDATION OF ARACHIDONIC-ACID IN DIFFERENT LIPOSOMES BELOW AND ABOVE PHASE-TRANSITION TEMPERATURE / G. CERVATO, P. VIANI, M. MASSERINI, C. DIIORIO, B. CESTARO. - In: CHEMISTRY AND PHYSICS OF LIPIDS. - ISSN 0009-3084. - 49:1-2(1988), pp. 135-139.
STUDIES ON PEROXIDATION OF ARACHIDONIC-ACID IN DIFFERENT LIPOSOMES BELOW AND ABOVE PHASE-TRANSITION TEMPERATURE
P. VIANISecondo
;B. CESTAROUltimo
1988
Abstract
The mechanism of Fe-induced peroxidation of arachidonic acid (AA) in small unilamellar vesicles (SUV) of dipalmitoylphosphatidylcholine (DPPC) and dipalmitoylphosphatidylethanolamine (DPPE) was studied below and above gel to liquid-crystalline phase transition temperature (Tm). In both liposomes the AA peroxidation resulted higher in the temperature range below Tm, but the extent of malonyldialdehyde (MDA) formation was dramatically lower in DPPE vesicles when compared with corresponding DPPC liposomes. A possible explanation for this is discussed.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
