Erythromycin A was transformed into clarithromycin by the sequence of reactions: selective thexyldimethylsilylation of the 9-oxime, trimethylsilylation of the 2',4 "-hydroxy groups, methylation of the resulting 2',4 "-[O-bis(trimethylsilyl)]-9-[O-(dimethylthexylsilyl)oxime] and acidic regeneration of the protected functionalities.
A new convenient transformation of erythromycin A into clarithromycin / P. Allevi, A. Longo, M. Anastasia. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - 7:12(1999), pp. 2749-2752. [10.1016/S0968-0896(99)00230-8]
A new convenient transformation of erythromycin A into clarithromycin
P. AlleviPrimo
;M. AnastasiaUltimo
1999
Abstract
Erythromycin A was transformed into clarithromycin by the sequence of reactions: selective thexyldimethylsilylation of the 9-oxime, trimethylsilylation of the 2',4 "-hydroxy groups, methylation of the resulting 2',4 "-[O-bis(trimethylsilyl)]-9-[O-(dimethylthexylsilyl)oxime] and acidic regeneration of the protected functionalities.
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