The stereoselective synthesis of two precursors of tricyclic beta-lactam antibiotics (trinems) has been attempted by a novel approach that involves a highly stereoselective azetidinone ring-forming reaction followed by the reduction of a functionalized aromatic substituent at C-4 of the beta-lactam nucleus.
A novel approach to the synthesis of precursors of tricyclic beta-lactam antibiotics / R. Annunziata, M. Benaglia, M. Cinquini, F. Cozzi, L. Poletti, L. Raimondi, A. Perboni. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - 1999:11(1999), pp. 3067-3072. [10.1002/(sici)1099-0690(199911)1999:11<3067::aid-ejoc3067>3.0.co;2-k]
A novel approach to the synthesis of precursors of tricyclic beta-lactam antibiotics
R. AnnunziataPrimo
;M. BenagliaSecondo
;M. Cinquini;F. Cozzi;L. Poletti;L. RaimondiPenultimo
;
1999
Abstract
The stereoselective synthesis of two precursors of tricyclic beta-lactam antibiotics (trinems) has been attempted by a novel approach that involves a highly stereoselective azetidinone ring-forming reaction followed by the reduction of a functionalized aromatic substituent at C-4 of the beta-lactam nucleus.
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