The applications of isoelectric focusing in immobilized pH gradients in clinical chemistry and forensic analysis are reviewed. Strong emphasis is given to the separation of serum proteins, in particular α1-acidic glycoprotein, acid phosphatase, alkaline phosphatase, α1-antitrypsin, apolipoproteins, complement component, factor B, factor XIIIB, group-specific component, lecithin:cholesterol acyltransferase, phosphoglucomutase, prealbumin, protein C and transferrin. The analysis of human parotid salivary proteins is discussed and an assessment is given of the state of the art in thalassaemia screening.
ISOELECTRIC-FOCUSING IN IMMOBILIZED PH GRADIENTS - APPLICATIONS IN CLINICAL-CHEMISTRY AND FORENSIC ANALYSIS / P. RIGHETTI, E. GIANAZZA, A. BIANCHIBOSISIO, P. SINHA, E. KOTTGEN. - In: JOURNAL OF CHROMATOGRAPHY B. BIOMEDICAL APPLICATIONS. - ISSN 0378-4347. - 569:1-2(1991), pp. 197-228.
ISOELECTRIC-FOCUSING IN IMMOBILIZED PH GRADIENTS - APPLICATIONS IN CLINICAL-CHEMISTRY AND FORENSIC ANALYSIS
E. GIANAZZASecondo
;
1991
Abstract
The applications of isoelectric focusing in immobilized pH gradients in clinical chemistry and forensic analysis are reviewed. Strong emphasis is given to the separation of serum proteins, in particular α1-acidic glycoprotein, acid phosphatase, alkaline phosphatase, α1-antitrypsin, apolipoproteins, complement component, factor B, factor XIIIB, group-specific component, lecithin:cholesterol acyltransferase, phosphoglucomutase, prealbumin, protein C and transferrin. The analysis of human parotid salivary proteins is discussed and an assessment is given of the state of the art in thalassaemia screening.
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