Methyl indol-2-ylpropiolate 1 is synthesized by using a catalyst system of PPh3-CuI in the presence of K2CO3 as base. The procedure appears convenient if compared with Pd-catalyzed cross-coupling reactions. The interest is increased by the use of an alk-1-yne containing an electron-withdrawing group.
Convenient synthesis of methyl indol-2-ylpropiolate / D. Passarella, G. Lesma, M. Deleo, M. Martinelli, A. Silvani. - In: JOURNAL OF THE CHEMICAL SOCIETY. PERKIN TRANSACTIONS. I. - ISSN 0300-922X. - :19(1999), pp. 2669-2670.
Convenient synthesis of methyl indol-2-ylpropiolate
D. PassarellaPrimo
;G. LesmaSecondo
;A. SilvaniUltimo
1999
Abstract
Methyl indol-2-ylpropiolate 1 is synthesized by using a catalyst system of PPh3-CuI in the presence of K2CO3 as base. The procedure appears convenient if compared with Pd-catalyzed cross-coupling reactions. The interest is increased by the use of an alk-1-yne containing an electron-withdrawing group.
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