Thirty four young adults were inoculated intranasally by nose drops, with two doses, two weeks apart, of inhibitor resistant 'Alice' vaccine strain of A/England/42/72 (H3N2). By the rate of volunteers with clinical reactions, always mild and short lasting, the vaccine showed a low degree of reactogenicity. Viral shedding was evidenced only the day after the first dose and was limited to two vaccines. Two weeks after the first dose homologous serum h.i.a. appeared in all the 15 volunteers lacking prevaccination antibody and significant titer rises occurred in a substantial number of vaccine recipients with low titers. The incidence of subjects with h.i.a. at titers considered to be protective (≥1:40), which was 26% before vaccination, rose to 93% in fully vaccinated volunteers. Very likely because of the presence of n.i.a. in the prevaccinal serum of all the volunteers, the n.i.a. response was less satisfactory. The vaccine induced h.i.a. to A/Port Chalmers/73 e A/Scotland/74 (H3N2) variants, although in a lower number of subjects and at a lower titer than to the homologous strain. Serum h.i. and n.i. antibody response appeared not to be significantly increased by a second dose. H.i.a., never present in the first sample, were found in the nasal washings taken two weeks after the second dose from 9 out of 16 vaccinees examined. Antibody was detected more frequently in the specimens with relatively high levels of protein and IgA. Secretory n.i.a., already demonstrable in 7 volunteers before vaccination, were acquired by all but one at the end of the experience.

Controllo clinico, studio dell'escrezione virale e valutazione della risposta in anticorpi circolanti e locali dopo somministrazione di vaccino influenzale vivente ed attenuato contenente il ceppo "Alice" / F. Bergamini, M.L. Profeta, P. Ferroni, A. R Zanetti. - In: BOLLETTINO DELL'ISTITUTO SIEROTERAPICO MILANESE. - ISSN 0021-2547. - 55:1(1976), pp. 1-12.

Controllo clinico, studio dell'escrezione virale e valutazione della risposta in anticorpi circolanti e locali dopo somministrazione di vaccino influenzale vivente ed attenuato contenente il ceppo "Alice"

A. R Zanetti
Ultimo
1976

Abstract

Thirty four young adults were inoculated intranasally by nose drops, with two doses, two weeks apart, of inhibitor resistant 'Alice' vaccine strain of A/England/42/72 (H3N2). By the rate of volunteers with clinical reactions, always mild and short lasting, the vaccine showed a low degree of reactogenicity. Viral shedding was evidenced only the day after the first dose and was limited to two vaccines. Two weeks after the first dose homologous serum h.i.a. appeared in all the 15 volunteers lacking prevaccination antibody and significant titer rises occurred in a substantial number of vaccine recipients with low titers. The incidence of subjects with h.i.a. at titers considered to be protective (≥1:40), which was 26% before vaccination, rose to 93% in fully vaccinated volunteers. Very likely because of the presence of n.i.a. in the prevaccinal serum of all the volunteers, the n.i.a. response was less satisfactory. The vaccine induced h.i.a. to A/Port Chalmers/73 e A/Scotland/74 (H3N2) variants, although in a lower number of subjects and at a lower titer than to the homologous strain. Serum h.i. and n.i. antibody response appeared not to be significantly increased by a second dose. H.i.a., never present in the first sample, were found in the nasal washings taken two weeks after the second dose from 9 out of 16 vaccinees examined. Antibody was detected more frequently in the specimens with relatively high levels of protein and IgA. Secretory n.i.a., already demonstrable in 7 volunteers before vaccination, were acquired by all but one at the end of the experience.
Settore MED/42 - Igiene Generale e Applicata
1976
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/176675
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