The synthesis of a series of 2-phenyl-1,4-benzodioxanes is reported. One of them, 2-(3-hydroxy-4-methoxyphenyl)-1,4-benzodioxane, is 450 times sweeter than sucrose, with an aftertaste similar to that of Phyllodulcin. Like this latter and other analogues, it satisfies the requirements of the Temussi sweet taste receptor model.
Synthesis and sweet taste of some 2-phenylbenzodioxanes / A. Arnoldi, L. Camarda, L. Merlini. - In: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. - ISSN 0021-8561. - 34:2(1986), pp. 339-344. [10.1021/jf00068a047]
Synthesis and sweet taste of some 2-phenylbenzodioxanes
A. ArnoldiPrimo
;L. MerliniUltimo
1986
Abstract
The synthesis of a series of 2-phenyl-1,4-benzodioxanes is reported. One of them, 2-(3-hydroxy-4-methoxyphenyl)-1,4-benzodioxane, is 450 times sweeter than sucrose, with an aftertaste similar to that of Phyllodulcin. Like this latter and other analogues, it satisfies the requirements of the Temussi sweet taste receptor model.
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