Background: Diffusion tensor magnetic resonance imaging tractography allows quantification of in vivo white matter tract damage. Methods: Using tractography, diffusion tensor magnetic resonance imaging metrics were obtained from the superior and middle cerebellar peduncles and major cerebral white matter tracts in 5 patients with progressive supranuclear palsy and 13 controls. Results: Patients showed severe intrinsic damage to the superior cerebellar peduncle, corpus callosum, and cingulum bilaterally. Only decreased axial diffusivity was found in the left middle cerebellar peduncle. Conclusions: Diffusion tensor magnetic resonance imaging tractography holds promise for providing accurate in vivo cartography of progressive supranuclear palsy tissue damage.
Diffusion tensor magnetic resonance imaging tractography in progressive supranuclear palsy / E. Canu, F. Agosta, F. Baglio, S. Galantucci, R. Nemni, M. Filippi. - In: MOVEMENT DISORDERS. - ISSN 0885-3185. - 26:9(2011 Aug 01), pp. 1752-1755.
Diffusion tensor magnetic resonance imaging tractography in progressive supranuclear palsy
R. NemniPenultimo
;
2011
Abstract
Background: Diffusion tensor magnetic resonance imaging tractography allows quantification of in vivo white matter tract damage. Methods: Using tractography, diffusion tensor magnetic resonance imaging metrics were obtained from the superior and middle cerebellar peduncles and major cerebral white matter tracts in 5 patients with progressive supranuclear palsy and 13 controls. Results: Patients showed severe intrinsic damage to the superior cerebellar peduncle, corpus callosum, and cingulum bilaterally. Only decreased axial diffusivity was found in the left middle cerebellar peduncle. Conclusions: Diffusion tensor magnetic resonance imaging tractography holds promise for providing accurate in vivo cartography of progressive supranuclear palsy tissue damage.File | Dimensione | Formato | |
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