Background: Diffusion tensor magnetic resonance imaging tractography allows quantification of in vivo white matter tract damage. Methods: Using tractography, diffusion tensor magnetic resonance imaging metrics were obtained from the superior and middle cerebellar peduncles and major cerebral white matter tracts in 5 patients with progressive supranuclear palsy and 13 controls. Results: Patients showed severe intrinsic damage to the superior cerebellar peduncle, corpus callosum, and cingulum bilaterally. Only decreased axial diffusivity was found in the left middle cerebellar peduncle. Conclusions: Diffusion tensor magnetic resonance imaging tractography holds promise for providing accurate in vivo cartography of progressive supranuclear palsy tissue damage.

Diffusion tensor magnetic resonance imaging tractography in progressive supranuclear palsy / E. Canu, F. Agosta, F. Baglio, S. Galantucci, R. Nemni, M. Filippi. - In: MOVEMENT DISORDERS. - ISSN 0885-3185. - 26:9(2011 Aug 01), pp. 1752-1755.

Diffusion tensor magnetic resonance imaging tractography in progressive supranuclear palsy

R. Nemni
Penultimo
;
2011

Abstract

Background: Diffusion tensor magnetic resonance imaging tractography allows quantification of in vivo white matter tract damage. Methods: Using tractography, diffusion tensor magnetic resonance imaging metrics were obtained from the superior and middle cerebellar peduncles and major cerebral white matter tracts in 5 patients with progressive supranuclear palsy and 13 controls. Results: Patients showed severe intrinsic damage to the superior cerebellar peduncle, corpus callosum, and cingulum bilaterally. Only decreased axial diffusivity was found in the left middle cerebellar peduncle. Conclusions: Diffusion tensor magnetic resonance imaging tractography holds promise for providing accurate in vivo cartography of progressive supranuclear palsy tissue damage.
progressive supranuclear palsy; diffusion tensor magnetic resonance imaging; tractography; superior cerebellar peduncle
Settore MED/26 - Neurologia
Settore MED/37 - Neuroradiologia
1-ago-2011
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/175389
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