Stereoselective synthesis and biological properties of PAF-acether, its enantiomer and some analogues of both are reported. The results clearly indicate that the ONIUM SIZE and SHAPE of the various compounds tested are important in determining guinea-pig bronchoconstriction and human platelet aggregation.
Cardiovascular and pulmonary activity of platelet-activating factor (PAF-acether) and its derivatives / F. Berti, V. Ferri, M. Pallavicini, M. Pretolani, E. Tremoli, E. Valoti, L. Villa. - In: PHARMACOLOGICAL RESEARCH COMMUNICATIONS. - ISSN 0031-6989. - 18:6(1986), pp. 557-562.
Cardiovascular and pulmonary activity of platelet-activating factor (PAF-acether) and its derivatives
M. Pallavicini;E. Tremoli;E. ValotiPenultimo
;
1986
Abstract
Stereoselective synthesis and biological properties of PAF-acether, its enantiomer and some analogues of both are reported. The results clearly indicate that the ONIUM SIZE and SHAPE of the various compounds tested are important in determining guinea-pig bronchoconstriction and human platelet aggregation.
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