A strategy featuring ring-closing metathesis as key reaction is applied to the synthesis of the sarcodictyin analogue 15. The precursor diene is accessed via a brief and efficient protocol. employing multiple stereoselective allylations. Simplified analogue 15 retains microtubule stabilising properties. (C) 2001 Elsevier Science Ltd. All rights reserved.
Synthesis of a simplified sarcodictyin analogue which retains microtubule stabilising properties / J. Telser, R. Beumer, A. Bell, S. Ceccarelli, D. Monti, C.M.A. Gennari. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 42:52(2001 Dec 24), pp. 9187-9190.
Synthesis of a simplified sarcodictyin analogue which retains microtubule stabilising properties
C.M.A. GennariUltimo
2001
Abstract
A strategy featuring ring-closing metathesis as key reaction is applied to the synthesis of the sarcodictyin analogue 15. The precursor diene is accessed via a brief and efficient protocol. employing multiple stereoselective allylations. Simplified analogue 15 retains microtubule stabilising properties. (C) 2001 Elsevier Science Ltd. All rights reserved.
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