Several studies have described in autistic patients an overgrowth of unusual gut bacterial strains, able to push the fermentation of tyrosine up to the formation of p-cresol. We compared levels of urinary p-cresol, measured by high-performance liquid chromatography-ultraviolet, in 59 matched case-control pairs. Urinary p-cresol was significantly elevated in autistic children smaller than 8 years of age (p < 0.01), typically females (p < 0.05), and more severely affected regardless of sex (p < 0.05). Urinary cotinine measurements excluded smoking-related hydrocarbon contaminations as contributors to these differences. Hence, elevated urinary p-cresol may serve as a biomarker of autism liability in small children, especially females and more severely affected males.
Urinary p-cresol is elevated in small children with severe autism spectrum disorder / L. Altieri, C. Neri, R. Sacco, P. Curatolo, A. Benvenuto, F. Muratori, E. Santocchi, C. Bravaccio, C. Lenti, M. Saccani, R. Rigardetto, M. Gandione, A. Urbani, AM. Persico. - In: BIOMARKERS. - ISSN 1354-750X. - 16:3(2011 May), pp. 252-260. [10.3109/1354750X.2010.548010]
Urinary p-cresol is elevated in small children with severe autism spectrum disorder
C. Lenti;
2011
Abstract
Several studies have described in autistic patients an overgrowth of unusual gut bacterial strains, able to push the fermentation of tyrosine up to the formation of p-cresol. We compared levels of urinary p-cresol, measured by high-performance liquid chromatography-ultraviolet, in 59 matched case-control pairs. Urinary p-cresol was significantly elevated in autistic children smaller than 8 years of age (p < 0.01), typically females (p < 0.05), and more severely affected regardless of sex (p < 0.05). Urinary cotinine measurements excluded smoking-related hydrocarbon contaminations as contributors to these differences. Hence, elevated urinary p-cresol may serve as a biomarker of autism liability in small children, especially females and more severely affected males.Pubblicazioni consigliate
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