The use of powder layering technology was explored to prepare hydrophilic matrix systems aimed at a zero-order release of drugs. Systems with 5 layers with decreasing drug concentration from the inner to the outer one were prepared by applying powders with different compositions onto inert cores. Various configurations of the layers, the use of soluble and insoluble diluents and two polymeric binder solutions were evaluated. Drug release data were analyzed applying a linear least square regression to fit zero-order equation.
Zero-order drug release obtained with gradient matrix systems based on hydrophilic polymers / M. Cerea, L. Palugan, A. Foppoli, M.D. Del Curto, G. Loreti, A. Gazzaniga - In: Proceedings of 2011 CRS Annual Meeting and Exposition[s.l] : CRS (Controlled Release Society), 2011 Jul. (( Intervento presentato al 38. convegno Annual Meeting & Exposition of the Controlled Release Society tenutosi a National Harbor (US-MD) nel 2011.
Zero-order drug release obtained with gradient matrix systems based on hydrophilic polymers
M. CereaPrimo
;L. PaluganSecondo
;A. Foppoli;M.D. Del Curto;G. LoretiPenultimo
;A. GazzanigaUltimo
2011
Abstract
The use of powder layering technology was explored to prepare hydrophilic matrix systems aimed at a zero-order release of drugs. Systems with 5 layers with decreasing drug concentration from the inner to the outer one were prepared by applying powders with different compositions onto inert cores. Various configurations of the layers, the use of soluble and insoluble diluents and two polymeric binder solutions were evaluated. Drug release data were analyzed applying a linear least square regression to fit zero-order equation.
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