A possible role for human endogenous retroviruses (HERV) in the pathogenesis of MS was investigated by analyzing HERV peptides-stimulated proliferation and cytokine production in MS patients with acute (AMS) or stable (SMS) disease. HERV peptides specific-proliferation and type 1 cytokine production by peripheral blood mononuclear cells was observed in AMS but not in SMS individuals, in whom a type 2 cytokine profile dominates. HERV peptides-stimulated immune responses were modified by changes in disease expression; mediated by CD4 + T lymphocytes; and not related to HLA class II molecules. These data suggest the possibility of a pathogenic role for HERV and HERV-specific immune responses in MS.
Immune responses to antigens of human endogenous retroviruses in patients with acute or stable multiple sclerosis / M. Clerici, M. L. Fusi, D. Caputo, F. R. Guerini, D. Trabattoni, A. Salvaggio, C. L. Cazzullo, D. Arienti, M. L. Villa, H. B. Urnovitz, P. Ferrante. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 99:2(1999 Oct), pp. 173-182.
Immune responses to antigens of human endogenous retroviruses in patients with acute or stable multiple sclerosis
M. ClericiPrimo
;D. Trabattoni;M. L. Villa;P. FerranteUltimo
1999
Abstract
A possible role for human endogenous retroviruses (HERV) in the pathogenesis of MS was investigated by analyzing HERV peptides-stimulated proliferation and cytokine production in MS patients with acute (AMS) or stable (SMS) disease. HERV peptides specific-proliferation and type 1 cytokine production by peripheral blood mononuclear cells was observed in AMS but not in SMS individuals, in whom a type 2 cytokine profile dominates. HERV peptides-stimulated immune responses were modified by changes in disease expression; mediated by CD4 + T lymphocytes; and not related to HLA class II molecules. These data suggest the possibility of a pathogenic role for HERV and HERV-specific immune responses in MS.Pubblicazioni consigliate
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