An unprecedented chiral spiropiperidine oxindole system quaternary 3-aminooxindole and relying on a ring closing acts as an highly constrained Freidinger gamma-lactam, adopting assessed by modelling and spectroscopical studies. was synthesized starting from enantiopure metathesis as the key step. This compound a type II beta-turn conformation in solution, as (C) 2010 Elsevier Ltd. All rights reserved.
The spiropiperidine-3,3 '-oxindole scaffold : a type II beta-turn peptide isostere / G. Lesma, N. Landoni, A. Sacchetti, A. Silvani. - In: TETRAHEDRON. - ISSN 0040-4020. - 66:25(2010 Jun), pp. 4474-4478. [10.1016/j.tet.2010.04.077]
The spiropiperidine-3,3 '-oxindole scaffold : a type II beta-turn peptide isostere
G. LesmaPrimo
;A. SilvaniUltimo
2010
Abstract
An unprecedented chiral spiropiperidine oxindole system quaternary 3-aminooxindole and relying on a ring closing acts as an highly constrained Freidinger gamma-lactam, adopting assessed by modelling and spectroscopical studies. was synthesized starting from enantiopure metathesis as the key step. This compound a type II beta-turn conformation in solution, as (C) 2010 Elsevier Ltd. All rights reserved.
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