Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of EV-D68 and its clinical impact during the fall-winter season of 2021/22. From 19 European countries, 58 institutes reported 10,481 (6.8%) EV-positive samples of which 1,004 (9.6%) were identified as EV-D68 (852 respiratory samples). Clinical data was reported for 969 cases. 78.9% of infections were reported in children (0-5 years); 37.9% of cases were hospitalised. Acute respiratory distress was commonly noted (93.1%) followed by fever (49.4%). Neurological problems were observed in 6.4% of cases with six reported with AFM. Phylodynamic/Nextstrain and phylogenetic analyses based on 694 sequences showed the emergence of two novel B3-derived lineages, with no regional clustering. In conclusion, we describe a large-scale EV-D68 European upsurge with severe clinical impact and the emergence of B3-derived lineages.
Epidemiological and clinical insights into the enterovirus D68 upsurge in Europe 2021/22 and the emergence of novel B3-derived lineages, ENPEN multicentre study / M.P. Simoes, E.B. Hodcroft, P. Simmonds, J. Albert, E.K. Alidjinou, K. Ambert-Balay, C. Andrés, A. Antón, C. Auvray, J. Bailly, F. Baldanti, C. Bastings, S. Beard, C.B. Pereira, N. Berginc, M. Bloemen, S. Blomqvist, F. Bosma, S. Böttcher, L. Bubba, S. Buderus, M. Cabrerizo, C. Calvo, C. Celma, F. Ceriotti, G. Clark, I. Costa, M. Coste-Burel, K. Couderé, J. Cremer, M. del Cuerpo Casas, T. Daehne, J. de Beer, M. de Ceano-Vivas, C. De Gascun, A. de Rougemont, J. Dean, J.L. Dembinski, S. Diedrich, J. Diez-Domingo, L. Dillner, D.H. Dorenberg, A. Ducancelle, S. Dudman, R. Dyrdak, A. Eis-Huebinger, I. Falces-Romero, A. Farkas, S. Feeney, M.D. Fernandez-Garcia, J. Flipse, K.T. Franck, C. Galli, I. Garrigue, F. Geeraedts, I. Georgieva, F. Giardina, R. Guiomar, E. Hauzenberger, E. Heikens, C. Henquell, D. Hober, A. Hönemann, H. Howson-Wells, Ž. Hruškar, N. Ikonen, B. Imbert, A.R. Jansz, M. Jeannoël, H. Jiřincová, L. Josset, K. Keeren, N. Kramer-Lindhout, S. Krokstad, M. Lazrek, H. Le Guillou-Guillemette, C. Lefeuvre, A. Lind, M.M. Lunar, M. Maier, S. Marque-Juillet, C.P. Mcclure, J. Mckenna, A. Meijer, A. Menasalvas Ruiz, B. Mengual-Chuliá, S. Midgley, A. Mirand, R. Molenkamp, M. Montes, A. Moreno-Docón, U. Morley, J. Murk, A. Navascués-Ortega, R. Nijhuis, L. Nikolaeva-Glomb, S.A. Nordbø, S. Numanovic, M. Oggioni, E. Oñate Vergara, J. Pacaud, M.L. Pacreau, M. Panning, E. Pariani, L. Pekova, L. Pellegrinelli, M. Petrovec, C. Pietsch, L. Pilorge, L. Piñeiro, A. Piralla, M. Poljak, B. Prochazka, N. Rabella, J.C. Rahamat-Langendoen, P. Rainetova, M. Reynders, A. Riezebos-Brilman, L. Roorda, C. Savolainen-Kopra, I. Schuffenecker, L.C. Smeets, A. Stoyanova, K. Stefic, C. Swanink, I. Tabain, J. Tjhie, L. Thouault, C. Tumiotto, S. Uceda Renteria, T. Uršič, S. Vallet, M. Van Ranst, P. Van Wunnik, J.J. Verweij, J. Vila, B. Wintermans, E. Wollants, K.C. Wolthers, F. Xavier López-Labrado, T.K. Fischer, H. Harvala, K.S.M. Benschop. - In: THE JOURNAL OF INFECTIOUS DISEASES. - ISSN 0022-1899. - (2024), pp. jiae154.1-jiae154.20. [Epub ahead of print] [10.1093/infdis/jiae154]
Epidemiological and clinical insights into the enterovirus D68 upsurge in Europe 2021/22 and the emergence of novel B3-derived lineages, ENPEN multicentre study
C. Galli;M. Oggioni;E. Pariani;L. Pellegrinelli;S. Uceda Renteria;
2024
Abstract
Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of EV-D68 and its clinical impact during the fall-winter season of 2021/22. From 19 European countries, 58 institutes reported 10,481 (6.8%) EV-positive samples of which 1,004 (9.6%) were identified as EV-D68 (852 respiratory samples). Clinical data was reported for 969 cases. 78.9% of infections were reported in children (0-5 years); 37.9% of cases were hospitalised. Acute respiratory distress was commonly noted (93.1%) followed by fever (49.4%). Neurological problems were observed in 6.4% of cases with six reported with AFM. Phylodynamic/Nextstrain and phylogenetic analyses based on 694 sequences showed the emergence of two novel B3-derived lineages, with no regional clustering. In conclusion, we describe a large-scale EV-D68 European upsurge with severe clinical impact and the emergence of B3-derived lineages.
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