Cobalamin is essential for infant neurodevelopment; high levels of propionylcarnitine, methylmalonic acid and/or homocysteine at expanded newborn screening allow the identification of maternal secondary deficiencies. An inadequate intake of cobalamin is a frequent cause of deficiency in pregnancy. Today’s aim is to define clinical and biochemical phenotype and the adequate therapy; future prevention strategies are needed.
I deficit di vitamina B12 di origine materna nel neonato: sfide attuali e future = Neonatal cobalamin deficiency secondary to maternal causes: today and future challenges / C. Montanari, L. Fiori, D. Tonduti, E. Bonaventura, I. Degrassi, M. Gambino, C. Sertori, M. Tosi, A. Bosetti, L. Alberti, S. Lucchi, C. Cereda, G. Zuccotti, E. Verduci. - In: GIORNALE DI GASTROENTEROLOGIA EPATOLOGIA E NUTRIZIONE PEDIATRICA. - 15:1(2023), pp. 6-11.
I deficit di vitamina B12 di origine materna nel neonato: sfide attuali e future = Neonatal cobalamin deficiency secondary to maternal causes: today and future challenges
C. Montanari
Primo
;D. Tonduti;M. Gambino;M. Tosi;G. ZuccottiPenultimo
;E. VerduciUltimo
2023
Abstract
Cobalamin is essential for infant neurodevelopment; high levels of propionylcarnitine, methylmalonic acid and/or homocysteine at expanded newborn screening allow the identification of maternal secondary deficiencies. An inadequate intake of cobalamin is a frequent cause of deficiency in pregnancy. Today’s aim is to define clinical and biochemical phenotype and the adequate therapy; future prevention strategies are needed.
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