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[(repor) -8.1999998093 (ted) -319.799987793 (to) -315 (be) -323.1000061035 (the) -321.3999938965 (most) -317.700012207 (pred) -7.6999998093 (ictive) -322.5 (test.) -325 (L) -33.9000015259 (A) -304.3999938965 (can) -318.3999938965 (be) -323.1000061035 (medi-) ] TJ
T*
[(ated) -596 (by) -595 (both) -596.200012207 (an) -7.5999999046 (ti-) ] TJ
/F8 1 Tf
8.3593997955 0 TD
() Tj
/F6 1 Tf
7.3499999046 0 0 6.5324001312 391.7478942871 335.3385009766 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 395.433013916 336.9259033203 Tm
[(GPI) -593.299987793 (and) -593.0999755859 (an) -7.5999999046 (ti-proth) -10.3999996185 (rombin) -596.200012207 (\(aP) -16.8999996185 (T) -10.8000001907 (\)) ] TJ
-9.2559995651 -1.220600009 TD
0.0001 Tc
[(antibo) -11.1000003815 (dies) -748.799987793 ([16].) -750.799987793 (Howe) -18.7999992371 (ver) 71 (,) ] TJ
/F8 1 Tf
12.2468996048 0 TD
0 Tc
() Tj
/F6 1 Tf
7.3499999046 0 0 6.5324001312 429.8456115723 323.3196105957 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 433.5306091309 324.9637145996 Tm
[(GPI-) -9.3999996185 (dependent) -754 (L) -33.9000015259 (A) -749.799987793 (wa) -13 (s) ] TJ
-13.1436004639 -1.2264000177 TD
[(found) -492.200012207 (to) -482.799987793 (be) -490.799987793 (a) -490.200012207 (stron) -9.6000003815 (ger) -486.6000061035 (risk) -487.3999938965 (factor) -490.5 (for) -485.8999938965 (thrombo) -13.6000003815 (sis) -485.700012207 (and) ] TJ
T*
0.0001 Tc
[(miscarria) -12.1999998093 (ges) -389.700012207 (than) -388.299987793 (aP) -14.8999996185 (T) 52.9000015259 (-) 0.1000000015 (d) -7.4000000954 (ependent) -394 (L) -33.7999992371 (A) -385.299987793 ([17,18].) -392.1000061035 (aCL) -390.700012207 (posi-) ] TJ
0 -1.220600009 TD
0 Tc
[(tivity) -476.3999938965 (alone) -475.6000061035 (is) -471.5 (not) -468.799987793 (a) -15.8000001907 (ssociated) -479.1000061035 (with) -476.700012207 (an) -470.3999938965 (increa) -17.3999996185 (sed) -470.8999938965 (risk) -470.1000061035 (of) ] TJ
0 -1.2264000177 TD
0.0002 Tc
[(thrombo) -13.3999996185 (sis) -450.799987793 (or) -452.700012207 (preg) -7.5 (nancy) -458.8999938965 (loss) -451.3999938965 ([16,17,19) -6.4000000954 (].) -449 (Data) -461.3999938965 (on) -449.299987793 (an) -7.4000000954 (ti-) ] TJ
/F8 1 Tf
T*
0 Tc
() Tj
/F6 1 Tf
7.3499999046 0 0 6.5324001312 309.8266906738 263.3385925293 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 313.5116882324 264.9259033203 Tm
[(GPI) -344.5 (antib) -10.6000003815 (odies) -344.6000061035 (are) -345 (more) -358.8999938965 (controvers) -13 (ial,) -342.299987793 (may) -8.5 (be) -340.3999938965 (be) -16.5 (cause) ] TJ
-0.8967000246 -1.220600009 TD
[(the) -419.700012207 (a) -10 (ssa) -9.3999996185 (y) -415 (i) 0 (s) -419.3999938965 (less) -420.5 (standardiz) -11.3000001907 (ed) -416.200012207 ([17].) -421.1000061035 (Accordingly,) -419.6000061035 (Otom) -8.3999996185 (o) ] TJ
0 -1.2264000177 TD
[(and) -309.700012207 (colleagues) -314.1000061035 ([20]) -309.3999938965 (ha) 10.3000001907 (ve) -309.8999938965 (re) -11.1000003815 (cently) -313.3999938965 (validated) -311.8999938965 (a) -316.6000061035 (scor) -8.5 (ing) -305.700012207 (sys) -15.1999998093 (-) ] TJ
T*
[(tem) -324.3999938965 (to) -326.6000061035 (quantif) -12.1999998093 (y) -322.3999938965 (the) -327.200012207 (thrombotic) -332.5 (or) -325.6000061035 (obste) -10.1000003815 (tric) -325.700012207 (risk) -325.3999938965 (depen) -8.5 (d-) ] TJ
0 -1.220600009 TD
[(ing) -305.700012207 (on) -299.1000061035 (aPL) -303.3999938965 (pro) -8.6999998093 (files.) ] TJ
0.8156999946 -1.2264000177 TD
-0.0188999996 Tc
[(Clinic) -5.8000001907 (al) -314.299987793 (e) -18.8999996185 (v) 6.8000001907 (ent) -18.8999996185 (s) -306.8999938965 (are) -312.3999938965 (m) -1.6000000238 (ore) -318.200012207 (r) 3.2000000477 (obustly) -312.3999938965 (a) -18.8999996185 (s) 3.2000000477 (sociated) -315.200012207 (with) -316.700012207 (aPL) -18.8999996185 (s) -309.8999938965 (of) ] TJ
-0.8156999946 -1.220600009 TD
-0.0182000007 Tc
[(the) -519.9000244141 (I) 2.4000000954 (gG) -523 (isotype,) -523.299987793 (an) -519.0999755859 (isolate) -5.0999999046 (d) -516.9000244141 (positivity) -520 (for) -522.5 (a) 0.6999999881 (CL) -18.2000007629 (s) -511.700012207 (o) -1.5 (r) -516.700012207 (a) 0.6999999881 (nti-) ] TJ
/F8 1 Tf
0 -1.2264000177 TD
0 Tc
() Tj
/F6 1 Tf
7.3499999046 0 0 6.5324001312 309.6565856934 179.3197021484 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 313.1148986816 180.9638061523 Tm
-0.0181000009 Tc
[(GPI) -385.1000061035 (a) 0.8000000119 (ntibodies) -385.200012207 (o) 4.4000000954 (f) -386.6000061035 (t) 3.0999999046 (he) -381 (IgM) -386.8999938965 (i) -1.1000000238 (soty) -5 (pe) -386.799987793 (being) -383.700012207 (r) 4 (arely) -381 (d) -2 (ete) -18.1000003815 (c) 8.1000003815 (ted) ] TJ
-0.8561999798 -1.2264000177 TD
-0.0178999994 Tc
[(in) -605.5999755859 (APS) -618.5999755859 (c) 1 (ohor) 4.1999998093 (t) -17.8999996185 (s) 6.5 (.) -604 (P) -5.5 (atient) -17.8999996185 (s) -595.200012207 (carrying) -603.299987793 (both) -605 (a) -4.8000001907 (CL/) 4.8000001907 (a) -4.8000001907 (nti-) ] TJ
/F8 1 Tf
21.4046001434 0 TD
0 Tc
() Tj
/F6 1 Tf
7.3499999046 0 0 6.5324001312 519.4204101562 167.3007965088 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 522.8787231445 168.9447937012 Tm
-0.0171000008 Tc
(GPI) Tj
-22.260799408 -1.220600009 TD
-0.0175999999 Tc
[(antibody) -276.3999938965 (isotypes) -274.700012207 (di) ] TJ
7.9138998985 0 TD
[(splay) -276.299987793 (a) -276.299987793 (h) -2.9000000954 (igher) -273.1000061035 (r) -1.2000000477 (isk) -275.299987793 (o) -0.8000000119 (f) -276.1000061035 (d) -1.3999999762 (e) -17.5 (v) 8.1999998093 (elo) 5 (p) -1.3999999762 (ing) -279 (c) 1.3999999762 (li) 5.3000001907 (ni) 5.3000001907 (cal) ] TJ
-7.9138998985 -1.2264000177 TD
-0.0177999996 Tc
[(e) -17.7999992371 (v) 7.9000000954 (ent) -17.7999992371 (s) -294.299987793 ([21].) -297.299987793 (S) 0.5 (ome) -299.700012207 (i) -0.8000000119 (nvestigators) -298.1000061035 (ha) 12.6999998093 (ve) -299.700012207 (re) -17.7999992371 (c) 8.3999996185 (e) 1.1000000238 (ntly) -299.700012207 (proposed) -302.5 (that) ] TJ
T*
-0.0195000004 Tc
[(aCL) -19.5 (s) -513 (and) -524 (a) -0.6000000238 (nti-) ] TJ
/F8 1 Tf
6.3751001358 0 TD
0 Tc
() Tj
/F6 1 Tf
7.3499999046 0 0 6.5324001312 372.1322021484 131.3007965088 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 375.6471862793 132.9447937012 Tm
-0.0175000001 Tc
[(GPI) -517.5 (I) 3.0999999046 (gA) -512.799987793 (antibodi) 5.3000001907 (e) -4.4000000954 (s) -517.5999755859 (b) 5 (e) -519.200012207 (i) -0.5 (nclud) 4.4000000954 (e) 1.3999999762 (d) -522 (i) 5.3000001907 (n) -518.4000244141 (t) -2.0999999046 (he) ] TJ
-7.2371001244 -1.220600009 TD
-0.0166999996 Tc
[(APS) -374.5 (l) 0.3000000119 (aboratory) -373.799987793 (c) 2.2000000477 (ri) 6.0999999046 (teri) 6.0999999046 (a.) -371.3999938965 (Howe) -16.7000007629 (v) 9 (e) 2.2000000477 (r) 74.8000030518 (,) -371.3999938965 (this) -372.200012207 (is) -372.200012207 (no) 5.8000001907 (t) -388.8999938965 (s) 3.7999999523 (up) 5.1999998093 (por) 5.4000000954 (t) -1.2999999523 (ed) -376.6000061035 (b) 5.8000001907 (y) ] TJ
0 -1.2264000177 TD
-0.0171000008 Tc
[(a) 13.3999996185 (v) 1.2000000477 (ai) 5.6999998093 (lable) -293.200012207 (d) -1 (ata) -17.1000003815 (:) -289.299987793 (the) -293.200012207 (d) -1 (ete) -17.1000003815 (c) 9.1000003815 (tion) -292.3999938965 (of) -298.799987793 (a) -304.799987793 (s) 3.4000000954 (ingle) -293.200012207 (I) -2.2999999523 (g) 4.9000000954 (A) -298.299987793 (aPL) -299.700012207 (p) 4.8000001907 (ositi) 5.6999998093 (v) 1.2000000477 (ity) -293.200012207 (i) -0.1000000015 (s) ] TJ
T*
-0.0197000001 Tc
[(mo) -3 (re) -579.299987793 (co) -3 (mmo) -3 (nl) -2.7000000477 (y) -561.9000244141 (a) -19.7000007629 (sso) -3 (c) -0.8000000119 (i) -2.7000000477 (a) -0.8000000119 (t) -4.3000001907 (e) -0.8000000119 (d) -564.700012207 (w) 0.400000006 (i) -2.7000000477 (t) -4.3000001907 (h) -566.299987793 (n) 0.1000000015 (o) -3 (n) 0.1000000015 (-) -2.7999999523 (c) -0.8000000119 (ri) -2.7000000477 (t) -4.3000001907 (e) -0.8000000119 (r) -3.4000000954 (i) 3.0999999046 (a) -567.700012207 (m) -2.4000000954 (ani) -2.7000000477 (f) -0.6000000238 (es) -5 (ta) -6.5999999046 (-) ] TJ
0 -1.220600009 TD
-0.0178999994 Tc
[(ti) 4.9000000954 (ons) -17.8999996185 (,) -305.799987793 (whil) 4.9000000954 (e) -299.799987793 (I) -3.0999999046 (gA) -304.8999938965 (testing) -302.5 (h) 2.5 (a) -17.8999996185 (s) -296.6000061035 (not) -291.799987793 (b) 4.5999999046 (een) -298.8999938965 (s) 2.5999999046 (hown) -298.8999938965 (to) -302 (increa) -17.8999996185 (s) 10 (e) -299.799987793 (the) ] TJ
0 -1.2264000177 TD
-0.0183000006 Tc
[(dia) -5.1999998093 (g) 3.7000000477 (nostic) -404.299987793 (accurac) -5.1999998093 (y) -398.6000061035 (for) -401.1000061035 (A) 1.2999999523 (PS) -405 ([22].) -402 (I) -3.5 (ntere) -5.1999998093 (s) 2.2000000477 (tingly,) -401.8999938965 (t) 2.9000000954 (his) -396.8999938965 (i) -1.2999999523 (s) -402.700012207 (n) 1.5 (ot) ] TJ
T*
-0.0194000006 Tc
[(consiste) -6.3000001907 (nt) -328 (w) -5 (i) -2.4000000954 (th) ] TJ
/F9 1 Tf
6.4214000702 0 TD
-0.0197999999 Tc
[(in) -335 (v) -19.7999992371 (i) 8.1999998093 (vo) ] TJ
/F6 1 Tf
3.0255999565 0 TD
-0.0183000006 Tc
[(findings) -18.2999992371 (,) -329.299987793 (w) -3.9000000954 (hich) -333.5 (are) -334.8999938965 (s) 2.2000000477 (upportive) -334.8999938965 (f) 0.8000000119 (or) -325.8999938965 (a) ] TJ
ET
0 0 0 1 K
1 J
1 j
0 w
10 M
[] 0 d
1 i
q
1 0 0 1 56.6930007935 693.1840209961 cm
0 0 m
481.8900146484 0 l
481.8900146484 -0.112999998 l
0 -0.112999998 l
B*
Q
538.5830078125 515.4520263672 -481.8900146484 0.1701000035 re
B*
224.7870025635 679.9180297852 -168.0939941406 0.1133999974 re
B*
538.5830078125 679.9180297852 -313.7950134277 0.1133999974 re
B*
224.7870025635 597.7700195312 -168.0939941406 0.1133399978 re
B*
538.5830078125 597.7700195312 -313.7950134277 0.1133399978 re
B*
224.7870025635 584.6170043945 -168.0939941406 0.1133999974 re
B*
538.5830078125 584.6170043945 -313.7950134277 0.1133999974 re
B*
BT
/F1 1 Tf
9 0 0 9 56.6929016113 697.2092895508 Tm
0 Tc
[(Table) -302.3999938965 (1) -298.3999938965 (Revised) -302.3999938965 (classification) -302 (criteria) -304.6000061035 (for) -301.1000061035 (anti-phospholipid) -302.799987793 (syndrome) -299.299987793 ([1]) ] TJ
/F5 1 Tf
7.9998998642 0 0 7.9998998642 56.6929016113 684.0565185547 Tm
0 0 0 rg
[(Clinical) -295.3999938965 (criteria) ] TJ
/F3 1 Tf
0.9991999865 -1.6440999508 TD
[(Vascula) 10.3999996185 (r) -304.299987793 (thrombos) 12.3999996185 (is) -12042.2998046875 (One) -294.1000061035 (or) -297.700012207 (more) -296.5 (episodes) -291.5 (of) -300.3999938965 (arterial,) -293.299987793 (venous) -295.799987793 (or) -297.700012207 (small) -292.5 (vessel) -295.299987793 (thrombosis) -294.3999938965 (in) -295.700012207 (any) -300 (tissue) -292.8999938965 (or) -297.700012207 (organ) ] TJ
20.0128002167 -1.1267999411 TD
[(\(confirmed) -291.799987793 (by) -297.6000061035 (objective) -286.8999938965 (validated) -299 (criteria) -292.200012207 (\(imaging) -293 (study) -295.1000061035 (or) -297.700012207 (histopatholog) 12 (y\)\)) ] TJ
-20.0128002167 -1.7503999472 TD
[(Pregnancy) -284.799987793 (complications) -9977 (One) -294.1000061035 (or) -297.700012207 (more) -296.5 (unexplaine) 12.6999998093 (d) -302.299987793 (deaths) -291.200012207 (of) -300.3999938965 (a) -297.1000061035 (morphologi) 12.3000001907 (cally) -296.8999938965 (normal) -298.200012207 (fetus) ] TJ
/F10 1 Tf
47.5870018005 0 TD
() Tj
/F3 1 Tf
0.6590999961 0 TD
[(10th) -292.5 (gestational) -288.8999938965 (week) ] TJ
-28.2332992554 -1.7503999472 TD
[(One) -294.1000061035 (or) -297.700012207 (more) -296.5 (prematu) 11.6000003815 (re) -300.1000061035 (births) -300 (\() ] TJ
/F10 1 Tf
12.7418003082 0 TD
() Tj
/F3 1 Tf
0.6590999961 0 TD
[(34th) -292.5 (gestational) -288.8999938965 (week\)) -298.3999938965 (of) -293.299987793 (a) -304.200012207 (morpho) 12.5 (logically) -297.1000061035 (normal) -291.1000061035 (neonate) ] TJ
-13.4008998871 -1.119699955 TD
[(because) -290.5 (of) -300.3999938965 (eclampsia) 9.8999996185 (,) -301.700012207 (severe) -295.700012207 (pre-eclamp) 11.8000001907 (sia) -299.1000061035 (or) -297.700012207 (placental) -290.6000061035 (insufficiency) ] TJ
0 -1.7503999472 TD
[(Three) -292 (or) -297.700012207 (more) -296.5 (unexplaine) 12.6999998093 (d) -302.299987793 (consecutiv) 11.1000003815 (e) -300.5 (spontane) 12.6000003815 (ous) -300 (abortions) ] TJ
/F10 1 Tf
25.7530002594 0 TD
() Tj
/F3 1 Tf
0.65200001 0 TD
[(9th) -296.700012207 (gestational) -288.8999938965 (week) -296.200012207 (\(maternal) ] TJ
-26.4048995972 -1.1267999411 TD
[(anatomi) 11 (c) -300 (and) -295.200012207 (hormonal) -292.1000061035 (abnormalit) 9.3000001907 (ies) -302.6000061035 (and) -295.200012207 (chromosom) 13.8999996185 (al) -301.700012207 (abnormalit) 9.3000001907 (ies) -295.5 (excluded\)) ] TJ
/F5 1 Tf
-21.0119991302 -1.6440999508 TD
[(Laboratory) -291.700012207 (criteria) ] TJ
/F3 1 Tf
0.9991999865 -1.6440999508 TD
[(Lupus) -293.8999938965 (anticoagu) 9.6000003815 (lant) -297.8999938965 (present) -294.1000061035 (in) -295.700012207 (plasma) -4451.8999023438 (Detected) -290.3999938965 (according) -288 (to) -300.8999938965 (the) -296.700012207 (guidelines) -293.5 (of) -293.299987793 (the) -296.700012207 (Internationa) 10.3000001907 (l) -302.200012207 (Society) -294.5 (of) -293.299987793 (Thrombosis) -294.299987793 (and) -295.200012207 (Haemostas) 12.6999998093 (is) ] TJ
20.0128002167 -1.1267999411 TD
[(\(Scientific) -286.8999938965 (subcommitt) 10 (ee) -296.299987793 (on) -298.6000061035 (lupus) -299 (anticoagu) 9.6000003815 (lant/phosphol) 10.5 (ipid-depend) 11.1999998093 (ent) -296.700012207 (antibodie) 10.8000001907 (s\)) ] TJ
-20.0128002167 -1.7503999472 TD
[(IgG) -295.299987793 (and/or) -292.3999938965 (IgM) -302.299987793 (anti-cardi) 10.8000001907 (olipin) -295.8999938965 (antibodie) 10.8000001907 (s) -302.1000061035 (i) 0 (n) ] TJ
0 -1.119699955 TD
[(serum) -290.700012207 (of) -300.3999938965 (plasma) ] TJ
20.0128002167 1.119699955 TD
[(At) -298.5 (medium) 12.8999996185 (/high) -298 (titer) -296 (\() ] TJ
/F10 1 Tf
9.1346998215 0 TD
() Tj
/F3 1 Tf
0.65200001 0 TD
[(40) -296.299987793 (GPL) -295.700012207 (or) -297.700012207 (MPL) -295.6000061035 (or) ] TJ
/F10 1 Tf
7.3631000519 0 TD
() Tj
/F3 1 Tf
0.6590999961 0 TD
[(99th) -292.5 (percentile\)) -292.200012207 (measured) -290.700012207 (by) -297.6000061035 (standard) -292 (ELISA) ] TJ
-37.8216018677 -2.8701000214 TD
[(IgG) -295.299987793 (and/or) -292.3999938965 (IgM) -302.299987793 (anti-) ] TJ
/F4 1 Tf
8.2276000977 0 TD
() Tj
/F3 1 Tf
5.9998002052 0 0 5.3324999809 134.8157043457 528.2645263672 Tm
(2) Tj
7.9998998642 0 0 7.9998998642 140.0881958008 529.6251220703 Tm
[(glycoprote) 10.5 (in) -302.700012207 (I) ] TJ
-9.4252996445 -1.1267999411 TD
[(antibod) 11.1999998093 (ies) -302.6000061035 (in) -295.700012207 (serum) -297.799987793 (or) -297.700012207 (plasma) ] TJ
20.0128002167 1.1267999411 TD
(Titer) Tj
/F10 1 Tf
2.0339000225 0 TD
() Tj
/F3 1 Tf
0.65200001 0 TD
[(99th) -292.5 (percentile) -297 (measure) 11.6000003815 (d) -302.299987793 (b) 0 (y) -297.6000061035 (standard) -292 (ELISA,) -295 (according) -295.1000061035 (to) -293.799987793 (recommende) 13.1999998093 (d) -302.299987793 (procedures) ] TJ
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[(be) 12.5 (tw) 18.2000007629 (ee) 14.6999998093 (n) -362 (a) 0 (P) 14 (S) 12.5 (/PT) -265 (an) 15.5 (d) -359.8999938965 (a) 0 (n) 15.5 (t) 0 (i) 15.1000003815 (-) ] TJ
/F8 1 Tf
10.8816003799 0 TD
() Tj
/F6 1 Tf
7.3499999046 0 0 6.5324001312 168.3211975098 71.3197021484 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 171.9496002197 72.9637985229 Tm
[(GP) 16.7000007629 (I) -361.200012207 (a) 0 (n) 15.5 (t) 0 (i) 15.1000003815 (b) 10.8999996185 (od) 15.5 (ie) 12.8000001907 (s;) -351.5 (ho) 13.8999996185 (wev) 11.1000003815 (er) 93.0999984741 (,) -360.5 (h) 0 (u) 11.8000001907 (-) ] TJ
-11.7609996796 -1.2264000177 TD
[(ma) 13.1000003815 (n) -651.299987793 (a) 0 (n) 15.5 (t) 0 (i) 15.1000003815 (-) ] TJ
/F8 1 Tf
4.3793001175 0 TD
() Tj
/F6 1 Tf
7.3499999046 0 0 6.5324001312 104.5983963013 59.3008003235 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 108.2267990112 60.9449005127 Tm
[(GP) 16.7000007629 (I) -656.200012207 (m) 0 (o) 16.6000003815 (n) 0 (o) 13.3000001907 (c) 0 (l) 18.6000003815 (o) 0 (n) 13.3000001907 (a) 0 (l) 12.8000001907 (s) -650.5 (or) -649.5999755859 (af) 14.8999996185 (fi) 13 (ni) 19.3999996185 (ty) 16.8999996185 (-p) 15.6999998093 (ur) 13.5 (i) 11.1999998093 (f) 0 (i) 13 (e) 0 (d) -647.5999755859 (a) 0 (n) 15.5 (t) 0 (i) 15.1000003815 (-) ] TJ
/F8 1 Tf
20.0508995056 17.1410007477 TD
() Tj
/F6 1 Tf
7.3499999046 0 0 6.5324001312 309.7699890137 227.3385009766 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 313.3417053223 228.9259033203 Tm
[(GP) 16.7000007629 (I) -419.1000061035 (p) 0 (o) 15.5 (l) 0 (y) 12.8000001907 (c) 0 (l) 18.6000003815 (o) 0 (n) 13.3000001907 (a) 0 (l) -409.5 (I) 0 (g) 13.6999998093 (G) -418 (an) 15.5 (ti) 15.1000003815 (b) 10.8999996185 (o) 0 (d) 15.5 (i) 0 (e) 12.8000001907 (s) -419.1000061035 (o) 10.8999996185 (b) 0 (t) 14.6999998093 (a) 0 (i) 12.8000001907 (n) 0 (e) 15.5 (d) -417.700012207 (fr) 18.1000003815 (om) -411.3999938965 (a) -432.299987793 (s) 0 (e) 16.2999992371 (r) 0 (u) 13.5 (m) ] TJ
-0.8792999983 -1.220600009 TD
[(re) 17.8999996185 (ac) 14.6999998093 (ti) 15.1000003815 (ng) -322.700012207 (wi) 19.7999992371 (th) -322.8999938965 (bo) 16 (th) ] TJ
/F8 1 Tf
7.9370999336 0 TD
() Tj
/F6 1 Tf
7.3499999046 0 0 6.5324001312 387.5527038574 215.3195953369 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 391.1242980957 216.9638061523 Tm
[(GP) 10.8999996185 (I) -326.5 (a) 0 (n) 15.5 (d) -331 (P) 12.3999996185 (S) 0 (/) 12 (P) 0 (T) -322.3999938965 (h) 0 (a) 27.7000007629 (v) 0 (e) -321.3999938965 (b) 0 (e) 12.5 (e) 0 (n) -320 (s) 0 (h) 17.7000007629 (o) 0 (w) 13.6999998093 (n) -327.299987793 (to) ] TJ
-8.8163995743 -1.2264000177 TD
[(re) 17.8999996185 (ac) 14.6999998093 (t) -262.299987793 (t) 0 (o) 14.6999998093 (w) 0 (a) 15.8999996185 (r) 0 (d) 15.1000003815 (s) ] TJ
/F8 1 Tf
5.7618999481 0 TD
() Tj
/F6 1 Tf
7.3499999046 0 0 6.5324001312 366.236114502 203.3007965088 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 369.807800293 204.9447937012 Tm
[(GP) 16.7000007629 (I) -262.8999938965 (o) 0 (n) 13.3000001907 (l) 11.1999998093 (y) -264.6000061035 ([) 9.6000003815 (26) 16.5 (].) ] TJ
/F9 1 Tf
-5.8255000114 -1.220600009 TD
[(In) -398.1000061035 (v) -10 (itro) ] TJ
/F6 1 Tf
3.5636000633 0 TD
[(exp) -8.1999998093 (eriment) -9.3999996185 (al) -392.200012207 (fin) -7.6999998093 (dings) -396.299987793 (sugg) -7.6999998093 (est) -396.3999938965 (that) -398.6000061035 (aP) -15 (T) 81.6999969482 (s) -396 (exert) ] TJ
-4.3793001175 -1.2264000177 TD
[(thrombo) -13.6000003815 (genic) -458.799987793 (effe) -16.6000003815 (ct) -12 (s) -459.6000061035 (interfering) -464.799987793 (with) -465.1000061035 (fluid) -460 (pha) -14 (se) -469.6000061035 (com-) ] TJ
T*
[(ponent) -20.6000003815 (s) -494.299987793 (o) 0 (f) -496.3999938965 (coagula) -11.8999996185 (tion) -498 (and) -494.799987793 (activ) -9.8000001907 (ating) -497 (endothe) -12.6999998093 (lial) -496.8999938965 (cells) ] TJ
0 -1.220600009 TD
[(\(ECs\).) -632.200012207 (E) 24 (viden) -8.1999998093 (ce) -621.700012207 (from) -630.5999755859 (animal) -625.799987793 (mod) -7.6999998093 (els) -626.200012207 (is) -621.9000244141 (rather) -628.5 (weak) -37.9000015259 (,) ] TJ
0 -1.2264000177 TD
[(howe) -16.5 (ver) 70.9000015259 (,) -308.3999938965 (main) -8 (ly) -305.3999938965 (be) -16.5 (cause) -307.3999938965 (of) -311.299987793 (the) -309.799987793 (lack) -307.1000061035 (of) -311.299987793 (cross) -16.8999996185 (-reactivity) -317.1000061035 (of) ] TJ
T*
0.0001 Tc
[(human) -308.200012207 (aP) -14.8999996185 (T) 81.8000030518 (s) -297.5 (with) -308.799987793 (animal) -307.5 (P) -10.6000003815 (T) -300 ([25].) ] TJ
0.8156999946 -1.220600009 TD
0 Tc
[(The) -370.799987793 (wide) -390.6000061035 (varia) -8.8999996185 (bility) -378.1000061035 (in) -379.700012207 (epitop) -9.6999998093 (e) -374.5 (spe) -13.8999996185 (cificitie) -14.1999998093 (s) -372.799987793 (and) -379.1000061035 (dete) -17.5 (c-) ] TJ
-0.8156999946 -1.2264000177 TD
[(tion) -451.799987793 (meth) -9.1000003815 (ods) -449.8999938965 (driv) -7.4000000954 (es) -446.5 (a) -455.5 (disparity) -456.8999938965 (across) -455 (available) -451.5 (studies) ] TJ
T*
[(about) -496.299987793 (the) -489.200012207 (pre) -18.1000003815 (valence) -494 (and) -494.799987793 (clinical) -491.799987793 (sign) -7.5 (ificance) -499.3999938965 (of) -484.799987793 (aP) -15 (T) 81.6999969482 (s) 0 (.) ] TJ
0 -1.220600009 TD
[(The) -382.299987793 (pre) -18.1000003815 (valence) -395.700012207 (of) -392.299987793 (antibo) -11.1999998093 (dies) -390.200012207 (targetin) -12.5 (g) -388.799987793 (P) -10.6999998093 (T) -392.700012207 (depends) -394.200012207 (also) ] TJ
0 -1.2264000177 TD
[(on) -651.9000244141 (sele) -17.2000007629 (ction) -658.5 (of) -652.5999755859 (study) -655 (popula) -10.5 (tions) -14.6999998093 (:) -649.799987793 (whe) -10 (n) -651.299987793 (considering) ] TJ
T*
[(solely) -463.6000061035 (indivi) -10.3999996185 (duals) -462.3999938965 (with) -459.299987793 (L) -33.9000015259 (A) -32.5 (,) -458.8999938965 (the) -466 (positivity) -469.700012207 (rate) -462.700012207 (increa) -17.3999996185 (ses) ] TJ
ET
0 0 0 1 K
1 J
1 j
0 w
10 M
[] 0 d
1 i
q
1 0 0 1 56.6930007935 693.1840209961 cm
0 0 m
481.8900146484 0 l
481.8900146484 -0.112999998 l
0 -0.112999998 l
B*
Q
538.5830078125 279.7229919434 -481.8900146484 0.1700700074 re
B*
120.81300354 679.9180297852 -64.1200027466 0.1133999974 re
B*
223.5970001221 679.9180297852 -102.783996582 0.1133999974 re
B*
241.0579986572 679.9180297852 -17.4610004425 0.1133999974 re
B*
373.2659912109 679.9180297852 -132.2079925537 0.1133999974 re
B*
538.5830078125 679.9180297852 -165.3159942627 0.1133999974 re
B*
BT
/F1 1 Tf
9 0 0 9 56.6929016113 697.2092895508 Tm
[(Table) -302.3999938965 (5) -298.3999938965 (Studies) -300.8999938965 (addressing) -299.5 (prevalence) -303.6000061035 (and) -300.799987793 (clinical) -305.6000061035 (association) -300.3999938965 (of) -298.1000061035 (aPS/PT) -305.799987793 (antibodies) ] TJ
/F5 1 Tf
7.9998998642 0 0 7.9998998642 56.6929016113 684.0565185547 Tm
0 0 0 rg
[(Referenc) 11 (e) -3749.1000976562 (Studied) -295.200012207 (populatio) 13.8000001907 (n) -4490.7998046875 (N) -1516.6999511719 (Prevalence) -287 (of) -295.299987793 (anti-PS/PT) -5940.8999023438 (Clinical) -295.3999938965 (associ) 11.3999996185 (ation) ] TJ
/F3 1 Tf
0 -1.6440999508 TD
(Galli) Tj
/F11 1 Tf
1.9843000174 0 TD
[(et) -299.299987793 (al) ] TJ
/F3 1 Tf
1.700799942 0 TD
0.301699996 Tc
(.[) Tj
0 0 0 1 k
0.7228000164 0 TD
0 Tc
(33) Tj
0 0 0 rg
0.956700027 0 TD
[(]) -2390.3999023438 (aPL-positive) -287.799987793 (subjects) -4580.3999023438 (59) -1224.6999511719 (90%) -14839.099609375 (No) -300.8999938965 (associat) 10.1999998093 (ion) -296.200012207 (with) -296.1000061035 (thrombosis) ] TJ
17.6812000275 -1.7503999472 TD
[(IgG) -295.299987793 (75%) ] TJ
T*
[(IgM) -295.200012207 (66%) ] TJ
-23.0459003448 -1.7503999472 TD
(Atsumi) Tj
/F11 1 Tf
3.0827000141 0 TD
[(et) -299.299987793 (al) ] TJ
/F3 1 Tf
1.700799942 0 TD
0.301699996 Tc
(.[) Tj
0 0 0 1 k
0.7299000025 0 TD
0 Tc
(37) Tj
0 0 0 rg
0.9495999813 0 TD
[(]) -1292 (Patients) -289.8999938965 (with) -296.1000061035 (autoimmune) ] TJ
1.5520000458 -1.1267999411 TD
(diseases) Tj
12.8480997086 1.1267999411 TD
[(265) -745.700012207 (IgG:) -292.299987793 (PAPS) -297.6000061035 (19%;) -294.299987793 (SLE) -295.299987793 (APS) -301.5 (63%;) -294.299987793 (SLE-no) ] TJ
2.1826999187 -1.1267999411 TD
[(APS) -294.5 (13%) ] TJ
16.5261001587 1.1267999411 TD
[(Association) -291.700012207 (with) -296.1000061035 (APS) ] TJ
-16.5261001587 -2.8771998882 TD
[(IgM:) -292.200012207 (PAPS) -297.6000061035 (10%;) -294.299987793 (SLE) -295.299987793 (APS) -301.5 (29%;) -294.299987793 (SLE-no) ] TJ
0 -1.119699955 TD
[(APS) -294.5 (4%) ] TJ
-23.0459003448 -1.7503999472 TD
(Nojima) Tj
/F11 1 Tf
3.1322999001 0 TD
[(et) -299.299987793 (al) ] TJ
/F3 1 Tf
1.700799942 0 TD
0.301699996 Tc
(.[) Tj
0 0 0 1 k
0.7299000025 0 TD
0 Tc
(62) Tj
0 0 0 rg
0.956700027 0 TD
[(]) -1235.3000488281 (SLE) -295.299987793 (patients) -8015.8999023438 (126) -745.700012207 (38.1%) -14194.099609375 (No) -300.8999938965 (associat) 10.1999998093 (ion) -296.200012207 (with) -296.1000061035 (stroke) ] TJ
-6.5197000504 -1.7503999472 TD
[(Bertolaccin) 12.6999998093 (i) ] TJ
/F11 1 Tf
4.8685002327 0 TD
[(et) -299.299987793 (al) ] TJ
/F3 1 Tf
1.700799942 0 TD
(.) Tj
-6.5693001747 -1.1267999411 TD
([) Tj
0 0 0 1 k
0.2621999979 0 TD
(47) Tj
0 0 0 rg
0.9495999813 0 TD
(]) Tj
6.8031997681 1.1267999411 TD
[(SLE) -295.299987793 (patients) -8015.8999023438 (212) -745.700012207 (31%) -14839.099609375 (No) -300.8999938965 (associat) 10.1999998093 (ion) -296.200012207 (with) -296.1000061035 (thrombosis) ] TJ
15.0307998657 -1.7503999472 TD
[(IgG-only) -288.700012207 (16%) ] TJ
T*
[(IgM-onl) 11.3999996185 (y) -300 (6) 0 (%) ] TJ
-23.0459003448 -1.7503999472 TD
(Tsutumi) Tj
/F11 1 Tf
3.4795999527 0 TD
[(et) -299.299987793 (al) ] TJ
/F3 1 Tf
1.700799942 0 TD
0.301699996 Tc
(.[) Tj
0 0 0 1 k
0.7228000164 0 TD
0 Tc
(51) Tj
0 0 0 rg
0.956700027 0 TD
[(]) -895.0999755859 (SLE) -295.299987793 (patients) -8015.8999023438 (139) -745.700012207 (21%) -14839.099609375 (Association) -291.700012207 (with) -296.1000061035 (thrombos) 12.3999996185 (is) ] TJ
-6.8598999977 -1.7503999472 TD
(Nojima) Tj
/F11 1 Tf
3.1322999001 0 TD
[(et) -299.299987793 (al) ] TJ
/F3 1 Tf
1.700799942 0 TD
0.301699996 Tc
(.[) Tj
0 0 0 1 k
0.7299000025 0 TD
0 Tc
(52) Tj
0 0 0 rg
0.956700027 0 TD
[(]) -1235.3000488281 (SLE) -295.299987793 (patients) -8015.8999023438 (175) -745.700012207 (43.4%) -14194.099609375 (Association) -291.700012207 (with) -296.1000061035 (thrombos) 12.3999996185 (is) ] TJ
-6.5197000504 -1.7503999472 TD
(Bardin) Tj
/F11 1 Tf
2.8134000301 0 TD
[(et) -299.299987793 (al) ] TJ
/F3 1 Tf
1.700799942 0 TD
0.301699996 Tc
(.[) Tj
0 0 0 1 k
0.7228000164 0 TD
0 Tc
(55) Tj
0 0 0 rg
0.956700027 0 TD
[(]) -1561.3000488281 (APS) -294.5 (patients) -7838.7001953125 (62) -1224.6999511719 (55%) -14839.099609375 (NI) ] TJ
-6.1936998367 -1.7503999472 TD
[(Jakowski) -291.700012207 ([) ] TJ
0 0 0 1 k
3.9969000816 0 TD
(56) Tj
0 0 0 rg
0.956700027 0 TD
[(]) -2801.3999023438 (APS) -294.5 (patients) -7838.7001953125 (58) -1224.6999511719 (44%) -14839.099609375 (No) -300.8999938965 (associat) 10.1999998093 (ion) -296.200012207 (with) -296.1000061035 (pregnancy) -293.3999938965 (loss) ] TJ
3.0613999367 -1.7503999472 TD
[(Women) -293.299987793 (with) -296.1000061035 (RPL) -5887.7001953125 (66) -1224.6999511719 (1%) ] TJ
-8.0150003433 -1.7503999472 TD
(Atsumi) Tj
/F11 1 Tf
3.0827000141 0 TD
[(et) -299.299987793 (al) ] TJ
/F3 1 Tf
1.700799942 0 TD
0.301699996 Tc
(.[) Tj
0 0 0 1 k
0.7299000025 0 TD
0 Tc
(63) Tj
0 0 0 rg
0.9495999813 0 TD
[(]) -1292 (Patients) -289.8999938965 (with) -296.1000061035 (autoimmune) ] TJ
1.5520000458 -1.1267999411 TD
(diseases) Tj
12.8480997086 1.1267999411 TD
[(441) -745.700012207 (18.3%) -14194.099609375 (Association) -291.700012207 (with) -296.1000061035 (APS) ] TJ
-12.8480997086 -2.8701000214 TD
[(PAPS) -10807.099609375 (84) -1224.6999511719 (39%) ] TJ
0 -1.7503999472 TD
[(SLE-APS) -9653.2001953125 (68) -1224.6999511719 (47%) ] TJ
T*
[(SLE-no) -295.8999938965 (APS) -8295.2998046875 (136) -745.700012207 (10%) ] TJ
T*
[(Rheumato) 11.6999998093 (id) -299.799987793 (arthritis) -4745.1000976562 (46) -1224.6999511719 (0) ] TJ
T*
[(Sjogren) -291.799987793 (syndrome) -5531.3999023438 (36) -1224.6999511719 (0) ] TJ
T*
[(Other) -10579.099609375 (71) -1224.6999511719 (4%) ] TJ
/F12 1 Tf
-8.0150003433 -1.7503999472 TD
<8E> Tj
/F3 1 Tf
0.5314999819 0 TD
(igon) Tj
/F11 1 Tf
2.1047000885 0 TD
[(et) -299.299987793 (al) ] TJ
/F3 1 Tf
1.700799942 0 TD
0.301699996 Tc
(.[) Tj
0 0 0 1 k
0.7299000025 0 TD
0 Tc
(64) Tj
0 0 0 rg
0.9495999813 0 TD
[(]) -1738.4000244141 (APS) -294.5 (patients) -7838.7001953125 (100) -745.700012207 (59%) -14839.099609375 (NI) ] TJ
-6.016600132 -1.7503999472 TD
(Vlagea) Tj
/F11 1 Tf
2.9196999073 0 TD
[(et) -299.299987793 (al) ] TJ
/F3 1 Tf
1.700799942 0 TD
0.2946000099 Tc
(.[) Tj
0 0 0 1 k
0.7228000164 0 TD
0 Tc
(65) Tj
0 0 0 rg
0.956700027 0 TD
[(]) -1455 (PAPS) -297.6000061035 (patients) -7335.6000976562 (98) -1224.6999511719 (51%,) -294.299987793 (IgG) -295.299987793 (35.7%,) -294.200012207 (IgM) -295.200012207 (32.6%) -5782.2001953125 (Association) -291.700012207 (with) -296.1000061035 (venous) -295.799987793 (thrombos) 12.3999996185 (is) -299.700012207 (and) -295.200012207 (obstetric) ] TJ
33.271900177 -1.1267999411 TD
(morbidity) Tj
-31.5569000244 -0.6236000061 TD
[(SAPS) -297.1000061035 (patients) -7378.1000976562 (45) -1224.6999511719 (53.3%,) -294.200012207 (IgG) -295.299987793 (40%,) -294.299987793 (IgM) -295.200012207 (31.1%) ] TJ
0 -1.7503999472 TD
[(aPL-positive) -287.799987793 (subjects) -4580.3999023438 (57) -1224.6999511719 (38.6%,) -294.200012207 (IgG) -295.299987793 (21.1%,) -294.200012207 (IgM) -295.200012207 (26.3%) ] TJ
-8.0150003433 -1.7503999472 TD
(Pregnolato) Tj
/F11 1 Tf
4.648900032 0 TD
[(et) -299.299987793 (al) ] TJ
/F3 1 Tf
1.700799942 0 TD
(.) Tj
-6.3496999741 -1.1267999411 TD
([) Tj
0 0 0 1 k
0.2621999979 0 TD
(26) Tj
0 0 0 rg
0.9495999813 0 TD
(]) Tj
6.8031997681 1.1267999411 TD
[(APS) -294.5 (patients) -7838.7001953125 (80) -1224.6999511719 (81.3%) -14194.099609375 (Association) -291.700012207 (with) -296.1000061035 (venous) -295.799987793 (thrombos) 12.3999996185 (is) -299.700012207 (\(IgG) -297.5 (only\)) ] TJ
/F2 1 Tf
6.9998998642 0 0 6.9998998642 56.6929016113 271.729095459 Tm
[(aPL,) -301.200012207 (anti-phosp) -15.3000001907 (holipid) -303.299987793 (antibody;) -307.799987793 (APS,) -309.1000061035 (anti-phosphol) -13.5 (ipid) -297 (syn) -10.5 (drome;) -300.8999938965 (aPS,) -304.5 (anti-phosp) -15.3000001907 (hatidylseri) -13.8000001907 (ne) -292.5 (antib) -10.3999996185 (odies;) -305.5 (Ig,) -301.700012207 (immunoglob) -13.6000003815 (ulin;) -301.1000061035 (NI,) -303 (not) -302.1000061035 (inves) ] TJ
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[(betw) -9.8999996185 (een) -376.299987793 (anti-do) -12.1999998093 (main) -378.200012207 (\(D\)I) -382.3999938965 (reactivity) -386 (and) -379.1000061035 (va) -14.8000001907 (scular) -385.5 (e) -10 (vent) -14.3999996185 (s) ] TJ
0 -1.2264000177 TD
0.0001 Tc
[(ha) -12.6999998093 (s) -303.299987793 (been) -307.3999938965 (suggested) -311.1000061035 ([67].) ] TJ
0.8156999946 -1.2264000177 TD
-0.0176999997 Tc
[(Th) -17.7000007629 (e) -302.3999938965 (r) -17.7000007629 (e) -5.5999999046 (a) -17.7000007629 (ct) -17.7000007629 (iv) -17.7000007629 (i) -5.5 (t) -17.7000007629 (y) -301.6000061035 (a) -17.7000007629 (ga) -17.7000007629 (i) -4.9000000954 (n) -17.7000007629 (st) -308.8999938965 (D) -17.7000007629 (I) -303.6000061035 (o) -6.8000001907 (f) ] TJ
/F8 1 Tf
11.5064001083 0 TD
0 Tc
() Tj
/F6 1 Tf
7.3499999046 0 0 6.5324001312 182.4944000244 191.3385009766 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 186.0661010742 192.925994873 Tm
[(GP) 10.8999996185 (I) -291.799987793 (was) -287.5 (de) 17.7000007629 (sc) 16.2999992371 (ri) 16 (be) 12.5 (d) -290.5 (f) 0 (o) 18.3999996185 (r) -296.1000061035 (th) 18.3999996185 (e) ] TJ
-13.2013998032 -1.220600009 TD
[(fi) 18.7999992371 (rs) 13.6999998093 (t) -308.6000061035 (t) 0 (i) 15.1000003815 (m) 0 (e) -305.1000061035 (i) 11.1999998093 (n) -310 (2) 0 (0) 16.5 (0) 0 (2) -301.6000061035 (b) 10.8999996185 (ut) -305.6000061035 (i) 11.1999998093 (t) 0 (s) -317 (i) 11.1999998093 (mp) 16.1000003815 (or) 15.6999998093 (ta) 16.8999996185 (nc) 15.5 (e) -310.799987793 (was) -304.8999938965 (rev) 13.1000003815 (ea) 14.6999998093 (le) 12.8000001907 (d) -307.799987793 (w) 0 (h) 17.3999996185 (e) 0 (n) -302.6000061035 (a) ] TJ
0 -1.2264000177 TD
[(tw) 12.3999996185 (o) 10.8999996185 (-) 0 (s) 14.3000001907 (t) 0 (e) 16.8999996185 (p) -718.5999755859 (tec) 12.6999998093 (hn) 17 (i) 11.1999998093 (q) 0 (u) 13.3000001907 (e) -715.799987793 (was) -709.799987793 (us) 17.7000007629 (ed) -711.200012207 (to) -708.4000244141 (ch) 16.1000003815 (ar) 17.8999996185 (ac) 14.6999998093 (te) 16.8999996185 (ri) 16 (ze) ] TJ
/F8 1 Tf
21.005399704 0 TD
() Tj
/F6 1 Tf
7.3499999046 0 0 6.5324001312 267.5905151367 167.3007965088 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 271.162109375 168.9447937012 Tm
[(GP) 10.8999996185 (I-) ] TJ
-21.8847999573 -1.2264000177 TD
[(de) 17.7000007629 (pe) 11.8999996185 (nd) 18.5 (en) 15.5 (t) -297 (a) 0 (P) 14 (L) 0 (s) -296.799987793 ([) 9.6000003815 (68) 16.5 (].) -293 (S) 12.5 (peci) 18.8999996185 (fi) 18.7999992371 (ca) 14.6999998093 (ll) 16.7000007629 (y,) ] TJ
/F8 1 Tf
13.9940004349 0 TD
() Tj
/F6 1 Tf
7.3499999046 0 0 6.5324001312 198.878692627 155.3385009766 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 202.450302124 156.925994873 Tm
[(GP) 10.8999996185 (I) -291.799987793 (c) 0 (o) 12.5 (a) 0 (t) 16.8999996185 (e) 0 (d) -288.8999938965 (o) 0 (n) -287.5 (h) 0 (y) 16.1000003815 (d) 0 (r) 15.1000003815 (o) 0 (-) ] TJ
-14.8732995987 -1.220600009 TD
[(ph) 13.3000001907 (i) 11.1999998093 (l) 0 (i) 16.7000007629 (c) -316.6000061035 (bu) 13.8999996185 (t) -314.3999938965 (n) 0 (o) 13.3000001907 (t) -314.3999938965 (hy) 16.1000003815 (dr) 15.1000003815 (o) 10.8999996185 (p) 0 (h) 13.3000001907 (o) 10.8999996185 (bi) 10.6000003815 (c) -310.799987793 (m) 0 (i) 11.1999998093 (c) 0 (r) 17.8999996185 (o) 0 (t) 14.6999998093 (i) 11.1999998093 (te) 11.1999998093 (r) -313.3999938965 (p) 0 (l) 15.8000001907 (a) 0 (t) 16.8999996185 (e) 0 (s) -307.700012207 (d) 0 (i) 15.8000001907 (s) 0 (p) 13.5 (l) 11.1999998093 (ay) 14.6999998093 (s) -315 (c) 0 (o) 12.5 (n) 0 (-) ] TJ
0 -1.2264000177 TD
[(fo) 12.6999998093 (rm) 16.2999992371 (at) 16.8999996185 (i) 11.1999998093 (o) 0 (n) 13.3000001907 (a) 0 (l) -264.8999938965 (c) 13.1000003815 (ha) 10.3000001907 (ng) 18.6000003815 (es) -261.3999938965 (th) 12.6000003815 (at) -260.700012207 (ex) 16.2000007629 (po) 15.5 (se) -261.3999938965 (DI) -262.799987793 (to) -262.8999938965 (th) 12.6000003815 (e) -270.299987793 (s) 0 (u) 17.7000007629 (r) 0 (f) 12.3000001907 (a) 0 (c) 20.5 (e) 0 (,) -266.3999938965 (m) 0 (a) 13.1000003815 (k) 14.1000003815 (in) 13.6999998093 (g) ] TJ
T*
[(it) -436.200012207 (mo) 16.6000003815 (re) -439.1000061035 (ac) 14.6999998093 (ce) 14.6999998093 (ss) 17.8999996185 (i) 11.1999998093 (b) 0 (l) 10.6000003815 (e) -443.8999938965 (fo) 18.3999996185 (r) -446.5 (a) 0 (u) 16.1000003815 (t) 0 (o) 14.6999998093 (a) 0 (n) 15.5 (t) 0 (i) 15.1000003815 (b) 10.8999996185 (od) 15.5 (y) -443.8999938965 (b) 0 (i) 10.6000003815 (n) 0 (d) 18.5 (i) 11.1999998093 (ng) 12.8000001907 (.) -441.5 (A) 0 (n) 16.2000007629 (t) 0 (i) 15.1000003815 (-) ] TJ
/F8 1 Tf
21.3640995026 0 TD
() Tj
/F6 1 Tf
7.3499999046 0 0 6.5324001312 271.0487976074 119.3386001587 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 274.6770935059 120.9260025024 Tm
[(GP) 16.7000007629 (I) ] TJ
-22.2434005737 -1.220600009 TD
[(an) 15.5 (ti) 15.1000003815 (b) 10.8999996185 (o) 0 (d) 15.5 (i) 0 (e) 12.8000001907 (s) -367.1000061035 (wi) 14 (th) -363.3999938965 (DI) -361.1000061035 (sp) 13.5 (eci) 14.3000001907 (fi) 13 (ci) 18.6000003815 (ty) -364.8999938965 (we) 15.8999996185 (re) -363.8999938965 (fo) 18.3999996185 (un) 11.1999998093 (d) -365.700012207 (i) 0 (n) -362.3999938965 (t) 0 (h) 12.6000003815 (e) -368.700012207 (ma) 13.1000003815 (jo) 17.8999996185 (ri) 16 (ty) ] TJ
0 -1.2264000177 TD
[(of) -305.5 (AP) 14.6000003815 (S) -317.299987793 (p) 0 (a) 17.7000007629 (t) 0 (i) 15.1000003815 (e) 0 (n) 15.5 (t) 0 (s) -317 (a) 0 (n) 15.5 (d) -319.3999938965 (we) 15.8999996185 (re) -306.1000061035 (si) 14.3999996185 (gn) 18.6000003815 (if) 13 (i) 11.1999998093 (c) 0 (a) 14.6999998093 (n) 0 (t) 12 (l) 11.1999998093 (y) -316.6000061035 (ass) 13.6999998093 (oc) 12.5 (i) 11.1999998093 (a) 0 (t) 16.8999996185 (e) 0 (d) -312.1000061035 (w) 0 (i) 19.7999992371 (t) 0 (h) -311.3999938965 (L) -22.2999992371 (A) ] TJ
T*
[(an) 15.5 (d) -388.799987793 (vas) 11.5 (cu) 16.1000003815 (la) 12.8000001907 (r) -388.6000061035 (t) 0 (h) 18.3999996185 (r) 0 (o) 15.6999998093 (m) 0 (b) 10.8999996185 (o) 10.8999996185 (s) 0 (i) 14.3999996185 (s) -390.200012207 (\(m) 15.3000001907 (o) 10.8999996185 (s) 0 (t) 12.8000001907 (l) 11.1999998093 (y) -391.799987793 (v) 0 (e) 14.1000003815 (n) 0 (o) 13.3000001907 (u) 0 (s) 17.7000007629 (\)) -389.6000061035 ([) 9.6000003815 (6) 0 (9) 16.5 (]) 0 (.) -385.6000061035 (O) 0 (n) 14 (l) 11.1999998093 (y) -391.799987793 (i) 11.1999998093 (n) -391 (a) ] TJ
0 -1.220600009 TD
[(su) 17.7000007629 (bs) 14.1000003815 (eq) 17.7000007629 (ue) 10.3000001907 (nt) -346.6000061035 (mu) 14.5 (lt) 15.1000003815 (ic) 12.8000001907 (en) 15.5 (te) 16.8999996185 (r) -359.700012207 (s) 0 (t) 18.6000003815 (u) 0 (d) 13.3000001907 (y) -357.1000061035 (we) 15.8999996185 (re) -352.3999938965 (th) 12.6000003815 (ey) -349.799987793 (al) 12.8000001907 (so) -350.3999938965 (fo) 18.3999996185 (un) 17 (d) -359.8999938965 (t) 0 (o) -355.5 (b) 10.8999996185 (e) ] TJ
0 -1.2264000177 TD
[(ass) 13.6999998093 (oc) 12.5 (i) 11.1999998093 (a) 0 (t) 16.8999996185 (e) 0 (d) -844.299987793 (w) 0 (i) 19.7999992371 (t) 0 (h) -843.5999755859 (t) 0 (h) 18.3999996185 (e) -848.799987793 (ob) 16 (st) 12.8000001907 (et) 16.8999996185 (ri) 16 (c) -848.799987793 (m) 11.5 (an) 15.5 (if) 13 (es) 16.2999992371 (ta) 16.8999996185 (ti) 15.1000003815 (on) 13.3000001907 (s) -841.4000244141 (o) 0 (f) -843.5 (t) 0 (h) 18.3999996185 (e) ] TJ
25.3094997406 64.8964004517 TD
[(sy) 16.2999992371 (nd) 12.8000001907 (ro) 21.5 (me) 13.1000003815 (,) -424.1000061035 (a) 0 (l) 18.6000003815 (t) 0 (h) 12.6000003815 (o) 0 (u) 13.8999996185 (g) 0 (h) -414.700012207 (t) 0 (o) -413.3999938965 (a) -426.5 (l) 11.1999998093 (e) 0 (s) 16.2999992371 (s) 0 (e) 10.5 (r) -417.5 (ex) 10.3999996185 (te) 16.8999996185 (nt) -416.1000061035 (th) 18.3999996185 (an) -418.299987793 (wi) 14 (th) -415.5 (th) 18.3999996185 (ro) 15.6999998093 (m-) ] TJ
0 -1.220600009 TD
[(bo) 16 (si) 14.3999996185 (s) -257.1000061035 ([) 3.7999999523 (70) 16.5 (].) -246.8000030518 (Ho) 11.5 (wev) 11.1000003815 (er) 93.0999984741 (,) -262.200012207 (s) 0 (o) 14.1000003815 (m) 0 (e) -253 (d) 0 (a) 17.7000007629 (t) 0 (a) -255 (f) 0 (r) 18.1000003815 (o) 0 (m) -255.1999969482 (t) 0 (h) 18.3999996185 (e) -258.799987793 (mu) 14.5 (lt) 15.1000003815 (ic) 12.8000001907 (en) 15.5 (te) 16.8999996185 (r) -255.6000061035 (s) 0 (t) 12.8000001907 (u) 0 (d) 13.3000001907 (y) ] TJ
0 -1.2264000177 TD
[(ar) 17.8999996185 (e) -368.700012207 (c) 0 (o) 18.2000007629 (n) 0 (t) 17.7999992371 (r) 0 (o) 15.6999998093 (v) 0 (e) 14.1000003815 (r) 0 (s) 13.6999998093 (i) 11.1999998093 (al) 12.8000001907 (.) -348.8999938965 (I) 0 (n) -347.200012207 (f) 0 (a) 14.8999996185 (ct,) -349.3999938965 (no) -345.299987793 (co) 18.2000007629 (rr) 15.3000001907 (el) 12.8000001907 (at) 16.8999996185 (i) 11.1999998093 (o) 0 (n) -351.1000061035 (b) 10.8999996185 (et) 16.8999996185 (we) 10.1000003815 (en) -343.1000061035 (L) -22.2999992371 (A) -356.3999938965 (an) 15.5 (d) ] TJ
T*
[(mi) 17 (sc) 16.2999992371 (ar) 12.1000003815 (ri) 16 (a) 13.1000003815 (g) 0 (e) 12 (s) -494.299987793 (was) -484.200012207 (fo) 12.6999998093 (un) 17 (d,) -483.200012207 (in) -489.6000061035 (co) 18.2000007629 (nt) 12 (ras) 15.3000001907 (t) -493.700012207 (t) 0 (o) -482.799987793 (sev) 11.5 (er) 17.8999996185 (al) -484.700012207 (pr) 15.1000003815 (evi) 13.8000001907 (ou) 13.8999996185 (s) ] TJ
0 -1.220600009 TD
[(pu) 13.3000001907 (b) 10.8999996185 (l) 0 (i) 16.7000007629 (c) 0 (a) 14.6999998093 (t) 0 (i) 15.1000003815 (o) 0 (n) 13.3000001907 (s) -424.8999938965 (an) 15.5 (d) -429.299987793 (t) 0 (h) 18.3999996185 (e) -426.5 (kn) 16.5 (ow) 13.6999998093 (n) -431.3999938965 (c) 0 (l) 18.6000003815 (i) 0 (n) 13.6999998093 (i) 11.1999998093 (ca) 14.6999998093 (l) -428.3999938965 (L) -22.2999992371 (A) -425.8999938965 (p) 0 (r) 15.1000003815 (e) 0 (d) 11.8999996185 (i) 11.1999998093 (ct) 16.8999996185 (iv) 12.1999998093 (e) -438.1000061035 (v) 0 (a) 19.8999996185 (l) 0 (u) 14.1999998093 (e) ] TJ
0 -1.2264000177 TD
[(fo) 12.6999998093 (r) -325 (m) 0 (i) 17 (s) 0 (c) 10.5 (a) 0 (r) 17.8999996185 (r) 0 (i) 16 (a) 0 (g) 17.7000007629 (e) 0 (s) -325 ([) 9.6000003815 (17) 16.5 (].) -322 (Hi) 17.6000003815 (gh) -322.1000061035 (lev) 13.8000001907 (el) 12.8000001907 (s) -326.6000061035 (o) 0 (f) -322.8999938965 (a) 0 (n) 15.5 (t) 0 (i) 15.1000003815 (b) 0 (o) 16 (d) 0 (i) 15.8000001907 (e) 0 (s) -325 (w) 0 (i) 19.7999992371 (t) 0 (h) -322.8999938965 (c) 0 (o) 12.5 (m) 0 (-) ] TJ
T*
[(pa) 17.7000007629 (ra) 12.1000003815 (b) 10.8999996185 (l) 0 (e) -415.299987793 (s) 0 (p) 19.2999992371 (ecif) 21.8999996185 (ic) 12.8000001907 (i) 11.1999998093 (t) 0 (y) -416.8999938965 (a) 0 (n) 15.5 (d) -417.700012207 (de) 17.7000007629 (tect) 16.5 (ed) -410.3999938965 (by) -415.6000061035 (a) -420.799987793 (r) 0 (e) 17.8999996185 (s) 0 (e) 16.2999992371 (a) 0 (r) 12.1000003815 (c) 13.1000003815 (h) -425.1000061035 (E) 0 (L) 19 (I) 0 (S) 15.6999998093 (A) -420.1000061035 (ki) 13.6999998093 (t) ] TJ
0 -1.220600009 TD
[(ha) 27.7000007629 (ve) -419.799987793 (b) 10.8999996185 (e) 0 (e) 14.6999998093 (n) -425.700012207 (rec) 13.6000003815 (en) 15.5 (tl) 15.1000003815 (y) -420.799987793 (ass) 13.6999998093 (oc) 12.5 (i) 11.1999998093 (a) 0 (t) 16.8999996185 (e) 0 (d) -416.200012207 (w) 0 (i) 14 (t) 0 (h) -415.5 (a) 0 (n) -412.6000061035 (i) 0 (n) 13.6999998093 (c) 0 (r) 17.8999996185 (eas) 12.1000003815 (ed) -416.200012207 (ri) 16 (sk) -416.6000061035 (f) 13.3000001907 (o) 0 (r) ] TJ
0 -1.2264000177 TD
[(th) 12.6000003815 (ro) 21.5 (mb) 10.8999996185 (o) 10.8999996185 (t) 0 (i) 15.1000003815 (c) -357.1000061035 (eve) 9.8999996185 (nts) -349.299987793 (in) -350.799987793 (a) -357.1000061035 (p) 0 (r) 20.8999996185 (o) 0 (s) 14.1000003815 (pec) 13.3999996185 (ti) 15.1000003815 (ve) -361.8999938965 (co) 18.2000007629 (ho) 13.8999996185 (rt) -350.1000061035 (o) 10.8999996185 (f) -356.8999938965 (SL) 13.3000001907 (E) -357.799987793 (o) 10.8999996185 (r) -359.700012207 (a) 0 (P) 19.7000007629 (L) ] TJ
T*
[(pa) 17.7000007629 (ti) 15.1000003815 (en) 15.5 (ts) -264.8999938965 (by) -253.6000061035 (th) 12.6000003815 (e) -264.6000061035 (s) 0 (a) 16.2999992371 (m) 11.5 (e) -264.6000061035 (g) 0 (r) 15.1999998093 (o) 10.8999996185 (up) -258.6000061035 ([) 9.6000003815 (7) 0 (1) 16.5 (]) 0 (.) ] TJ
0.8156999946 -1.220600009 TD
[(Re) -15 (cent) -505.5 (studi) -8.8999996185 (es) -487 (have) -490.5 (demonstrate) -14 (d) -487.200012207 (tha) -9 (t) -487.8999938965 (patien) -9.6000003815 (t) -13.5 (s) -488.5 (with) ] TJ
-0.8156999946 -1.2264000177 TD
[(multiple) -346.799987793 (positive) -345.8999938965 (test) -340.5 (result) -13 (s) -338.1000061035 (\(that) -342.700012207 (is) -20.2999992371 (,) -337.3999938965 (L) -33.9000015259 (A) -32.5 (,) -337.3999938965 (aCL) -14.8000001907 (s) -332.299987793 (a) 0 (n) -7.5999999046 (d) -336.799987793 (anti-) ] TJ
/F8 1 Tf
T*
() Tj
/F6 1 Tf
7.3499999046 0 0 6.5324001312 309.8266906738 551.3385009766 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 313.5116882324 552.92578125 Tm
[(GPI) -599 (aut) -9 (oantibodi) -13.3999996185 (es) -596.9000244141 (particu) -10 (larly) -600.200012207 (of) -600.5999755859 (the) -599.0999755859 (IgG) -601 (isotype\)) ] TJ
-0.8967000246 -1.220600009 TD
[(display) -407.6000061035 (a) -403.3999938965 (much) -403.299987793 (higher) -405.700012207 (risk) -400.6000061035 (for) -404.8999938965 (de) -11.3000001907 (velo) -10 (ping) -399.5 (clin) -8.3000001907 (ical) -402.5 (com-) ] TJ
0 -1.2264000177 TD
[(plicatio) -13.3000001907 (ns) -422.5 ([17].) -432.700012207 (In) -422.3999938965 (line) -430.6000061035 (with) -430.3999938965 (the) -431.299987793 (hypo) -8.8999996185 (thesis) -431.1000061035 (that) -427.5 (an) -7.5999999046 (ti-DI) ] TJ
T*
[(IgG) -421.700012207 (may) -419.299987793 (repres) -8.6000003815 (ent) -420.299987793 (a) -415 (mor) -7.5 (e) -415 (predi) -8.1000003815 (ctive) -420.5 (aPL) -419.1000061035 (profile) -11.8999996185 (,) -412.6000061035 (the) -9 (se) ] TJ
0 -1.220600009 TD
[(patien) -9.6000003815 (t) -7.6999998093 (s) -372.799987793 (tend) -375.299987793 (to) -367.1000061035 (have) -369 (a) -368.700012207 (higher) -376.799987793 (pre) -12.3000001907 (valenc) -9.6000003815 (e) -368.700012207 (and) -373.299987793 (higher) -376.799987793 (ti-) ] TJ
0 -1.2264000177 TD
[(ters) -304.8999938965 (of) -305.5 (anti-) ] TJ
/F8 1 Tf
4.8998999596 0 TD
() Tj
/F6 1 Tf
7.3499999046 0 0 6.5324001312 357.8456115723 491.3006896973 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 361.5306091309 492.9447937012 Tm
0.0002 Tc
[(GPI-D) -9.1000003815 (I) -297.3999938965 (antib) -10.3999996185 (odies) -303.8999938965 ([72,73].) ] TJ
-4.9808998108 -1.2264000177 TD
0 Tc
(Anti-) Tj
/F8 1 Tf
2.2156999111 0 TD
() Tj
/F6 1 Tf
7.3499999046 0 0 6.5324001312 339.5338134766 479.3385009766 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 343.2188110352 480.9259033203 Tm
[(GPI-DI) -376.299987793 (IgG) -375.3999938965 (antibodies) -384.1000061035 (ha) 10.3000001907 (ve) -373.5 (bee) -9.1000003815 (n) -367.799987793 (found) -376.6000061035 (a) -15.8000001907 (s) -367.1000061035 (the) ] TJ
-3.9279999733 -1.220600009 TD
[(most) -358.200012207 (pre) -12.3000001907 (valent) -354.5 (anti) -9.8999996185 (bodies) -356.799987793 (not) -353.1000061035 (only) -355.700012207 (in) -350.799987793 (primar) -7.9000000954 (y) -345.6000061035 (A) 0 (P) -8.5 (S) -346.200012207 (with) ] TJ
0 -1.2264000177 TD
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T*
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(data.) Tj
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[(T) 18.1000003815 (h) 0 (e) -302.1000061035 (f) 0 (a) 14.8999996185 (c) 0 (t) -307 (t) 0 (h) 18.3999996185 (a) 0 (t) -301.200012207 (t) 0 (h) 12.6000003815 (e) -310.799987793 (an) 15.5 (ti) 15.1000003815 (-) 11.1000003815 (D) 0 (I) -303.299987793 (a) 0 (n) 15.5 (t) 0 (i) 15.1000003815 (b) 10.8999996185 (od) 15.5 (ie) 12.8000001907 (s) -309.200012207 (a) 0 (r) 17.8999996185 (e) -310.799987793 (di) 15.8000001907 (rec) 13.6000003815 (te) 11.1999998093 (d) -307.799987793 (a) 0 (g) 17.7000007629 (a) 0 (i) 12.8000001907 (n) 0 (s) 17.2000007629 (t) ] TJ
-0.8156999946 -1.2264000177 TD
-0.0143999998 Tc
[(t) -14.3999996185 (h) -1.7999999523 (e) -359.8999938965 (i) -14.3999996185 (mmu) -14.3999996185 (n) -3.2000000477 (od) -14.3999996185 (om) -14.3999996185 (in) -14.3999996185 (an) -14.3999996185 (t) -361 (e) -14.3999996185 (pi) -14.3999996185 (to) -14.3999996185 (pe) -365.700012207 (of) ] TJ
/F8 1 Tf
13.9651002884 0 TD
0 Tc
() Tj
/F6 1 Tf
7.3499999046 0 0 6.5324001312 198.595199585 515.3385009766 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 202.1669006348 516.9259033203 Tm
[(GP) 10.8999996185 (I) -349.6000061035 (i) 11.1999998093 (s) -349.700012207 (s) 0 (u) 12 (p) 0 (p) 14.8999996185 (o) 10.8999996185 (rt) 14.3999996185 (ed) -341 (al) 12.8000001907 (so) ] TJ
-14.8444004059 -1.220600009 TD
[(by) -375.1000061035 (pa) 17.7000007629 (th) 12.6000003815 (og) 15.5 (en) 15.5 (i) 11.1999998093 (c) -386 (st) 18.6000003815 (ud) 13.3000001907 (ie) 12.8000001907 (s) -378.6000061035 (i) 0 (n) -373.8999938965 (a) 0 (n) 15.5 (i) 0 (m) 17 (a) 0 (l) -374.799987793 (m) 0 (o) 10.8999996185 (d) 0 (e) 17.7000007629 (l) 0 (s) 14.3999996185 (.) -383.6000061035 (P) 12.3999996185 (ass) 13.6999998093 (iv) 12.1999998093 (e) -380.299987793 (i) 0 (n) 13.6999998093 (f) 0 (u) 16.2999992371 (s) 0 (i) 14.3999996185 (o) 10.8999996185 (n) ] TJ
0 -1.2264000177 TD
[(of) -415.3999938965 (a) -426.5 (s) 0 (y) 10.5 (n) 0 (t) 17.7999992371 (h) 0 (e) 16.1000003815 (t) 0 (i) 15.1000003815 (c) -420.799987793 (an) 15.5 (ti) 15.1000003815 (ge) 17.7000007629 (ni) 13.6999998093 (c) -420.799987793 (t) 0 (a) 16.8999996185 (r) 0 (g) 15.1999998093 (e) 0 (t) -411.200012207 (p) 0 (e) 17.7000007629 (p) 0 (t) 14.1999998093 (i) 0 (d) 15.8000001907 (e) -420.799987793 (DI) -413.200012207 (was) -414.799987793 (sh) 17.7000007629 (ow) 13.6999998093 (n) -419.8999938965 (t) 0 (o) ] TJ
T*
[(pr) 15.1000003815 (o) 10.8999996185 (tec) 12.6999998093 (t) -372.200012207 (n) 0 (a) 15.5 11.1999998093 (ve) -361.8999938965 (mi) 11.1999998093 (ce) -361.3999938965 (fr) 18.1000003815 (om) -365.200012207 (th) 18.3999996185 (e) -368.700012207 (t) 0 (h) 12.6000003815 (r) 0 (o) 15.6999998093 (m) 0 (b) 16.6000003815 (o) 0 (g) 15.5 (e) 0 (n) 15.5 (i) 0 (c) -363.200012207 (e) 0 (f) 14.8999996185 (fec) 16.3999996185 (ts) -374.799987793 (o) 10.8999996185 (f) -391.6000061035 (hu) 11.8000001907 (-) ] TJ
0 -1.220600009 TD
[(ma) 13.1000003815 (n) -385.200012207 (p) 0 (o) 15.5 (l) 0 (y) 12.8000001907 (c) 0 (l) 18.6000003815 (o) 0 (n) 13.3000001907 (a) 0 (l) -380.6000061035 (a) 0 (P) 19.7999992371 (L) -392.5 (Ig) 19.3999996185 (G) -389.1000061035 (f) 0 (r) 18.1000003815 (a) 0 (c) 14.6999998093 (t) 0 (i) 15.1000003815 (o) 0 (n) 13.3000001907 (s) -384.3999938965 ([) 9.6000003815 (7) 0 (6) 16.5 (]) 0 (.) -379.799987793 (A) 0 (l) 13.5 (t) 0 (h) 12.6000003815 (o) 10.8999996185 (ug) 13.3999996185 (h) -384.6000061035 (t) 0 (h) 12.6000003815 (e) -386 (in) 13.6999998093 (-) ] TJ
0 -1.2264000177 TD
[(hi) 14.1999998093 (b) 10.8999996185 (i) 0 (t) 15.1000003815 (i) 0 (o) 16.3999996185 (n) -425.700012207 (of) -421.200012207 (th) 18.3999996185 (ro) 15.6999998093 (mb) 16.6000003815 (us) -421.8999938965 (fo) 18.3999996185 (rm) 16.2999992371 (at) 11.1999998093 (i) 11.1999998093 (o) 0 (n) -420.5 (a) 0 (s) -429.1000061035 (w) 0 (e) 15.8999996185 (l) 11.1999998093 (l) -428.3999938965 (a) 0 (s) -429.1000061035 (e) 0 (x) 16.2000007629 (p) 0 (r) 15.1000003815 (e) 0 (s) 16.2999992371 (s) 0 (i) 20.2000007629 (o) 0 (n) -420.5 (o) 10.8999996185 (f) ] TJ
T*
[(ad) 17.7000007629 (he) 10.3000001907 (si) 20.2000007629 (on) -287.5 (m) 11.5 (o) 0 (l) 10.6000003815 (ecu) 17.7000007629 (le) -288 (o) 10.8999996185 (n) -292.6000061035 (ao) 12.5 (rt) 14.3999996185 (i) 11.1999998093 (c) -293.5 (EC) 18.3999996185 (s) -291.799987793 (a) 0 (n) 15.5 (d) -296.299987793 (ti) 15.1000003815 (ss) 17.8999996185 (ue) -284.700012207 (fa) 14.8999996185 (ct) 16.8999996185 (or) -285.200012207 (ex) 16.2000007629 (pr) 15.1000003815 (es-) ] TJ
0 -1.220600009 TD
[(si) 14.3999996185 (o) 10.8999996185 (n) -321.5 (on) -310.6000061035 (ma) 13.1000003815 (cr) 17.8999996185 (op) 15.5 (ha) 16.1000003815 (ge) 12 (s) -320.799987793 (w) 0 (e) 15.8999996185 (r) 0 (e) -311.8999938965 (n) 0 (o) 19.1000003815 (t) -320.1000061035 (co) 12.5 (mp) 16.1000003815 (le) 18.6000003815 (te) 11.1999998093 (,) -320 (t) 0 (h) 18.3999996185 (i) 0 (s) -315.299987793 (f) 13.3000001907 (in) 13.6999998093 (di) 15.8000001907 (ng) -311.1000061035 (was) ] TJ
0 -1.2264000177 TD
[(th) 12.6000003815 (o) 10.8999996185 (u) 0 (g) 13.3999996185 (h) 0 (t) -294 (t) 0 (o) -297.700012207 (r) 0 (e) 17.8999996185 (p) 0 (r) 15.1000003815 (e) 0 (s) 16.2999992371 (e) 0 (n) 15.5 (t) -308.6000061035 (a) -299.299987793 (p) 0 (r) 15.1000003815 (o) 0 (o) 16 (f) -304.8999938965 (of) -299.700012207 (co) 18.2999992371 (nc) 15.5 (ep) 11.8999996185 (t) -302.799987793 (o) 0 (f) -293.8999938965 (t) 0 (h) 12.6000003815 (e) -305.1000061035 (pa) 17.7000007629 (th) 12.6000003815 (o) 10.8999996185 (g) 0 (e) 12 (n) 0 (i) 19.3999996185 (c) ] TJ
T*
[(ro) 15.6999998093 (l) 11.1999998093 (e) -438.1000061035 (of) -427 (an) 15.5 (ti) 15.1000003815 (-) 11.1000003815 (D) 0 (I) -430.5 (a) 0 (n) 15.5 (t) 0 (i) 20.7999992371 (b) 0 (o) 10.3000001907 (d) 0 (i) 15.8000001907 (e) 13.1000003815 (s) -436.5 ([) 9.6000003815 (76) 16.5 (].) -431.8999938965 (Mo) 18.1000003815 (re) -427.6000061035 (rec) 13.6000003815 (en) 15.5 (tl) 15.1000003815 (y,) -428.3999938965 (a) -432.299987793 (h) 0 (u) 17.5 (m) 0 (a) 13.1000003815 (n) ] TJ
0 -1.220600009 TD
[(mo) 16.6000003815 (no) 13.3000001907 (cl) 18.6000003815 (on) 13.3000001907 (al) -328.5 (Ig) 19.3999996185 (G,) -327.299987793 (sp) 13.5 (eci) 14.3000001907 (fi) 13 (ca) 20.5 (ll) 16.7000007629 (y) -339.799987793 (r) 0 (e) 17.8999996185 (a) 0 (c) 14.6999998093 (t) 0 (i) 15.1000003815 (n) 0 (g) -328.5 (w) 0 (i) 19.7999992371 (t) 0 (h) -328.700012207 (D) 0 (I) 14.8999996185 (,) -331.6000061035 (was) -333.799987793 (sh) 17.7000007629 (ow) 13.6999998093 (n) ] TJ
0 -1.2264000177 TD
[(to) -274.5 (in) 13.6999998093 (du) 19.1000003815 (ce) -286.200012207 (cl) 12.8000001907 (o) 10.8999996185 (t) 0 (t) 13.3999996185 (i) 0 (n) 13.6999998093 (g) -278.799987793 (an) 15.5 (d) -284.700012207 (f) 0 (e) 14.8999996185 (t) 0 (a) 16.8999996185 (l) -283.799987793 (l) 11.1999998093 (o) 0 (s) 14.1000003815 (s) -286.1000061035 (i) 11.1999998093 (n) -286.799987793 (na) 21.2999992371 12.1999998093 (e) -281.8999938965 (m) 0 (i) 17 (c) 0 (e) 14.6999998093 (,) -285.299987793 (o) 10.8999996185 (f) 0 (f) 15.1000003815 (e) 0 (r) 12.1000003815 (i) 11.1999998093 (ng) -276.3999938965 (th) 18.3999996185 (e) ] TJ
T*
[(fi) 18.7999992371 (rs) 13.6999998093 (t) -302.799987793 (d) 0 (i) 15.8000001907 (rec) 13.6000003815 (t) -302.799987793 (d) 0 (e) 11.8999996185 (m) 11.5 (on) 13.3000001907 (st) 18.6000003815 (ra) 12.1000003815 (ti) 15.1000003815 (o) 10.8999996185 (n) -304.200012207 (of) -293.8999938965 (th) 12.6000003815 (e) -305.1000061035 (p) 0 (a) 17.7000007629 (t) 0 (h) 18.3999996185 (o) 0 (g) 15.5 (e) 0 (n) 15.5 (i) 0 (c) -299.6000061035 (e) 0 (f) 14.8999996185 (fec) 16.3999996185 (t) -302.799987793 (o) 0 (f) -299.700012207 (a) 0 (n) 15.5 (t) 0 (i) 15.1000003815 (-) ] TJ
0 -1.220600009 TD
[(DI) -395.799987793 (an) 15.5 (ti) 15.1000003815 (b) 10.8999996185 (o) 0 (d) 15.5 (i) 0 (e) 12.8000001907 (s) -401.799987793 ([) 9.6000003815 (7) 0 (7) 16.5 (]) 0 (.) -397.200012207 (I) 0 (n) 17.2000007629 (t) 0 (e) 16.8999996185 (r) 0 (e) 17.8999996185 (s) 0 (t) 12.8000001907 (i) 11.1999998093 (ng) 12.8000001907 (l) 11.1999998093 (y) 0 (,) -393.700012207 (t) 0 (h) 12.6000003815 (e) -403.3999938965 (an) 15.5 (ti) 15.1000003815 (-) 11.1000003815 (D) 0 (I) -395.799987793 (m) 0 (o) 16.6000003815 (n) 0 (o) 13.3000001907 (c) 0 (l) 18.6000003815 (o) 0 (n) 13.3000001907 (a) 0 (l) ] TJ
0 -1.2264000177 TD
[(in) 13.6999998093 (du) 19.1000003815 (ce) 14.6999998093 (d) -302 (c) 0 (l) 12.8000001907 (o) 10.8999996185 (tt) 13.3999996185 (in) 13.6999998093 (g) -313.5 (v) 12.6000003815 (ia) -299.6000061035 (co) 18.2000007629 (mp) 16.1000003815 (le) 12.8000001907 (me) 13.1000003815 (nt) -294.6000061035 (ac) 14.6999998093 (ti) 15.1000003815 (v) 12.6000003815 (a) 0 (t) 11.1999998093 (i) 11.1999998093 (o) 0 (n) -299.1000061035 (a) 0 (n) 15.5 (d) -302 (o) 10.8999996185 (n) 0 (l) 13.6999998093 (y) -305 (af) 14.8999996185 (te) 16.8999996185 (r) ] TJ
T*
[(th) 12.6000003815 (e) -328.200012207 (c) 13.1000003815 (on) 13.3000001907 (co) 12.5 (m) 11.5 (i) 0 (t) 15.1000003815 (a) 0 (n) 15.5 (t) -320.1000061035 (ad) 17.7000007629 (mi) 17 (ni) 13.6999998093 (st) 18.6000003815 (ra) 12.1000003815 (ti) 20.7999992371 (on) -310.6000061035 (of) -311.299987793 (sm) 14.6999998093 (al) 18.6000003815 (l) -318.5 (a) 0 (m) 13.1000003815 (o) 10.8999996185 (un) 11.1999998093 (ts) -317 (of) -311.299987793 (l) 11.1999998093 (i) 0 (p) 15.8000001907 (o) 0 (-) ] TJ
0 -1.220600009 TD
[(po) 15.5 (ly) 18.6000003815 (sa) 10.5 (cc) 14.6999998093 (ha) 16.1000003815 (ri) 16 (de) 17.7000007629 (.) -262.200012207 (T) 18.1000003815 (hi) 14.1999998093 (s) -257.1000061035 (f) 0 (i) 13 (n) 0 (d) 18.5 (i) 0 (n) 13.6999998093 (g) -261.5 (i) 11.1999998093 (s) -262.8999938965 (in) -252.3999938965 (li) 16.7000007629 (ne) -256.3999938965 (wi) 14 (th) -253.5 (pr) 15.1000003815 (evi) 13.8000001907 (o) 10.8999996185 (u) 0 (s) -254.1999969482 (r) 0 (e) 17.8999996185 (s) 0 (u) 12 (l) 11.1999998093 (ts) ] TJ
0 -1.2264000177 TD
[(ob) 16 (ta) 16.8999996185 (in) 13.6999998093 (ed) -404.6000061035 (us) 12 (i) 11.1999998093 (n) 0 (g) -409.5 (p) 0 (o) 15.5 (l) 11.1999998093 (yc) 14.6999998093 (lo) 16.3999996185 (na) 15.5 (l) -416.799987793 (I) 0 (g) 19.3999996185 (G) -418 (an) 15.5 (ti) 15.1000003815 (-) ] TJ
/F8 1 Tf
15.0005998611 0 TD
() Tj
/F6 1 Tf
7.3499999046 0 0 6.5324001312 208.7433013916 311.3006896973 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 212.3148956299 312.9447937012 Tm
[(GP) 10.8999996185 (I) -413.299987793 (f) 0 (r) 18.1000003815 (a) 0 (c) 14.6999998093 (t) 0 (i) 15.1000003815 (o) 10.8999996185 (ns) -410.8999938965 (fr) 18.1000003815 (om) ] TJ
-15.8798999786 -1.2264000177 TD
[(AP) 14.6000003815 (S) -485 (p) 0 (a) 17.7000007629 (t) 0 (i) 15.1000003815 (e) 0 (n) 15.5 (t) 0 (s) -484.700012207 (a) 0 (n) 15.5 (d) -487.200012207 (fu) 16.2999992371 (rt) 14.3999996185 (he) 16.1000003815 (r) -481.200012207 (s) 0 (u) 12 (p) 0 (p) 14.8999996185 (o) 10.8999996185 (rts) -480 (th) 18.3999996185 (e) -484.3999938965 (p) 0 (o) 15.5 (t) 0 (e) 11.1999998093 (n) 0 (t) 17.7999992371 (i) 0 (a) 12.8000001907 (l) -480.5 (pa) 11.8999996185 (th) 18.3999996185 (o-) ] TJ
0 -1.220600009 TD
[(ge) 17.7000007629 (ni) 13.6999998093 (c) -264.6000061035 (r) 0 (o) 21.5 (l) 0 (e) -259.1000061035 (o) 10.8999996185 (f) -264.3999938965 (a) 0 (n) 15.5 (t) 0 (i) 15.1000003815 (-) 11.1000003815 (DI) -257 (an) 15.5 (ti) 20.7999992371 (bo) 10.3000001907 (di) 15.8000001907 (e) 13.1000003815 (s) 0 (.) ] TJ
0.8156999946 -1.2264000177 TD
[(The) -463.299987793 (main) -476.6000061035 (epitop) -9.6000003815 (e) -472.799987793 (o) 0 (f) -473.299987793 (D) 0 (I) -471 (h) 0 (a) -12.8000001907 (s) -471.200012207 (been) -475.299987793 (sugg) -7.6999998093 (ested) -477.1000061035 (to) -471.200012207 (be) -473.5 (a) ] TJ
-0.8156999946 -1.2264000177 TD
[(cryptic) -387.5 (and) -379.1000061035 (con) -8.3000001907 (formation-d) -12.1999998093 (epend) -8.5 (ent) -391.3999938965 (structu) -11.6000003815 (re) -375.5 (inv) -8.5 (olving) ] TJ
0 -1.220600009 TD
[(differ) -9.1000003815 (ent) -443.3999938965 (residues) -447.200012207 (located) -450.799987793 (in) -437.6000061035 (the) -448.700012207 (proximity) -446.3999938965 (of) -444.3999938965 (the) -442.8999938965 (junc-) ] TJ
0 -1.2264000177 TD
[(tion) -480.700012207 (betw) -9.8999996185 (een) -480.3999938965 (DI) -482.6000061035 (and) -483.200012207 (DII.) -481.200012207 (Fine) -483 (epitop) -9.6000003815 (e) -478.6000061035 (mappin) -10.3999996185 (g) -481.299987793 (using) ] TJ
T*
[(short) -431.3999938965 (synthetic) -424.8999938965 (peptide) -419.3999938965 (fragme) -9 (nt) -11.1000003815 (s) -413.299987793 (and) -413.799987793 (muta) -9.1000003815 (tion) -417.1000061035 (experi-) ] TJ
0 -1.220600009 TD
[(ment) -15.3999996185 (s) -644.700012207 (h) 0 (a) 10.3000001907 (v) 0 (e) -645.4000244141 (demon) -9.5 (strate) -10.3000001907 (d) -643.4000244141 (that) -647.299987793 (the) -645.4000244141 (main) -650.0999755859 (epitope) -650.200012207 (on) ] TJ
/F8 1 Tf
0 -1.2264000177 TD
() Tj
/F6 1 Tf
7.3499999046 0 0 6.5324001312 61.79529953 203.3007965088 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 65.4803009033 204.9447937012 Tm
[(GPI-) -9.3999996185 (DI) -430.5 (is) -431 (located) -439.200012207 (arou) -8.6999998093 (nd) -432.700012207 (amino) -436.700012207 (acid) -432.299987793 (40) -434.700012207 (of) -432.799987793 (the) -431.299987793 (mol-) ] TJ
-0.8967000246 -1.220600009 TD
[(e) -10 (cule) -416.6000061035 (with) -418.799987793 (R39-R4) -8.8000001907 (3) -414 (representing) -422.200012207 (the) -413.8999938965 (ke) -7.5 (y) -409.200012207 (con) -8.3000001907 (stituent) -418.3999938965 (of) ] TJ
0 -1.2264000177 TD
[(the) -483.3999938965 (disco) -9.1000003815 (ntinuou) -9.5 (s) -477 (epitop) -9.6000003815 (e) -478.6000061035 ([) -2 (68].) -484.799987793 (DI) -476.799987793 (of) ] TJ
/F8 1 Tf
16.834400177 0 TD
() Tj
/F6 1 Tf
7.3499999046 0 0 6.5324001312 226.7716064453 179.3197021484 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 230.4566040039 180.9638061523 Tm
[(GPI) -483.299987793 (is) -477.299987793 (usually) ] TJ
-17.7311000824 -1.2264000177 TD
[(hidden,) -339 (being) -333.700012207 (linked) -331 (with) -332 (DII) -334.700012207 (in) -327.700012207 (the) -344.5 (circular) -336.3999938965 (form) -329.700012207 (of) -334.3999938965 (the) ] TJ
0 -1.220600009 TD
[(mole) -16.7999992371 (cule,) -418.3999938965 (the) -419.700012207 (most) -416 (abunda) -10.6999998093 (nt) -416.1000061035 (variant) -419.1000061035 (in) -414.3999938965 (the) -431.299987793 (circulation.) ] TJ
0 -1.2264000177 TD
[(After) -471.8999938965 (intera) -9.3999996185 (ction) -467.6000061035 (with) -470.8999938965 (ani) -7.9000000954 (onic) -465.6000061035 (PL) -466.8999938965 (mon) -9.8999996185 (olayers) -474.299987793 (or) -464.5 (when) ] TJ
T*
[(bound) -303.700012207 (to) -297.700012207 (endo) -9.5 (toxin,) ] TJ
/F8 1 Tf
8.8280000687 0 TD
() Tj
/F6 1 Tf
7.3499999046 0 0 6.5324001312 148.3652954102 131.3007965088 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 152.0503997803 132.9447937012 Tm
[(GPI) -298.200012207 (is) -298 (opened) -304.200012207 (and) -298.1000061035 (DI) -303.299987793 (can) -301.1000061035 (be) -299.8999938965 (pre-) ] TJ
-9.7304000854 -1.220600009 TD
[(sented) -411 (to) -413.3999938965 (the) -408.200012207 (affere) -10.1999998093 (nt) -404.5 (limb) -412.1000061035 (of) -409.6000061035 (the) -408.200012207 (immu) -9 (ne) -406.799987793 (syste) -9.8999996185 (m) -405 ([) -2 (69].) ] TJ
0 -1.2264000177 TD
[(In) -445.6000061035 (ot) -8.3999996185 (her) -447.700012207 (words) -25.8999996185 (,) -447.299987793 (i) 0 (t) -447.700012207 (could) -454.700012207 (be) -450.299987793 (spe) -13.8000001907 (culate) -12 (d) -446.700012207 (that) -16.7999992371 (,) -447.299987793 (unlike) -454 (the) ] TJ
T*
[(other) -352 (dom) -7.6999998093 (ains) -22.1000003815 (,) -348.8999938965 (which) -354.5 (can) -347.3999938965 (indu) -7.6999998093 (ce) -344 (tol) -8.6999998093 (erance) -351.1000061035 (at) -347.5 (high) -354.200012207 (anti-) ] TJ
0 -1.220600009 TD
[(gen) -703 (concent) -10.5 (rations) -25.7999992371 (,) -701.799987793 (D) 0 (I) -696.700012207 (d) 0 (o) -7.6999998093 (e) 0 (s) -695.299987793 (not.) -707.799987793 (So,) -701.5999755859 (e) -10 (ven) -700.799987793 (a) -710 (small) ] TJ
0 -1.2264000177 TD
[(amount) -608.9000244141 (of) -600.5999755859 (DI) -604.0999755859 (presente) -11.3000001907 (d) -602.9000244141 (t) 0 (o) -598.5 (the) -604.9000244141 (immu) -9 (ne) -603.5 (system) -605.799987793 (can) ] TJ
T*
[(break) -308.5 (the) -304 (toleran) -10 (ce) -303.5 (and) -303.8999938965 (ea) -14.3000001907 (sily) -302.5 (induce) -305.5 (spe) -13.8000001907 (cif) -8.6000003815 (ic) -299.6000061035 (antibo) -11.1999998093 (dies.) ] TJ
/F5 1 Tf
9.2000999451 0 0 9.2000999451 304.7243041992 696.92578125 Tm
[(Antibodies) -308.3999938965 (agai) -8.1999998093 (nst) -299.700012207 (phos) -9.1000003815 (phatidylethano) -13 (lamine) ] TJ
/F6 1 Tf
9.7999000549 0 0 9.7999000549 304.7243041992 684.9636230469 Tm
[(Phosph) -9.1999998093 (atidyle) -10.8000001907 (thanolam) -11.8999996185 (ine) -742.5999755859 (\(PE\)) -748.5 (is) -737.5999755859 (a) -744.700012207 (zwitt) -9.8999996185 (erionic) -748.9000244141 (PL) -21.3999996185 (,) ] TJ
T*
[(main) -8 (ly) -444.200012207 (located) -456.6000061035 (in) -443.3999938965 (the) -448.700012207 (inn) -7.0999999046 (er) -444.8999938965 (leaflet) -19.3999996185 (s) -448 (o) 0 (f) -479.1000061035 (biologica) -12.6000003815 (l) -440 (mem) -10.1000003815 (-) ] TJ
T*
[(branes) -10.3000001907 (.) -482 (Subpopula) -13 (tions) -483.299987793 (of) -484.8999938965 (aPE) -488.5 (bind) -485.700012207 (to) -482.799987793 (high) -487.200012207 (mole) -16.7999992371 (cular) ] TJ
0 -1.220600009 TD
[(weight) -395.299987793 (kininogen,) -392.200012207 (leadi) -10.3999996185 (ng) -386.299987793 (to) -384.3999938965 (the) -390.799987793 (formation) -398.200012207 (of) -386.5 (antibody-) ] TJ
0 -1.2264000177 TD
[(PE-k) -7.9000000954 (ininogen) -925.0999755859 (trimole) -20.2000007629 (cular) -920.9000244141 (compl) -12.3000001907 (exes) -922.0999755859 (that) -925 (enhance) ] TJ
T*
[(thrombin) -10.8999996185 (-indu) -8.1999998093 (ced) -773.299987793 (platele) -10.8000001907 (t) -771.4000244141 (aggr) -7.5999999046 (egation) -10.1999998093 (.) -771.200012207 (P) 0 (E) -773.5 (promo) -9.3999996185 (tes) ] TJ
0 -1.220600009 TD
[(thrombo) -13.6000003815 (sis) -370 (by) -369.3999938965 (activ) -9.8000001907 (ating) -381.299987793 (factor) -380.6000061035 (X) -365.8999938965 (a) 0 (n) -7.5999999046 (d) -365.700012207 (P) -16.5 (T) 81.6999969482 (,) -366.299987793 (and) -373.299987793 (work) -13.8000001907 (s) -372.799987793 (a) -10 (s) ] TJ
0 -1.2264000177 TD
[(an) -424.1000061035 (anticoagula) -16 (nt) -421.8999938965 (potentia) -12.1999998093 (ting) -423.299987793 (activ) -9.8000001907 (ated) -422.3999938965 (prote) -9.1000003815 (in) -420.200012207 (C) -422.200012207 (activ) -9.8000001907 (-) ] TJ
T*
[(ity.) -390.200012207 (T) 12.3000001907 (h) 0 (e) -388.799987793 (finding) -389.8999938965 (that) -392.799987793 (PE) -385.8999938965 (in) -385.5 (the) -385 (hex) -9.8000001907 (agonal) -390 (pha) -14.1000003815 (se) -388.6000061035 (inhibit) -15.6000003815 (s) ] TJ
0 -1.220600009 TD
[(the) -448.700012207 (prolong) -8.3999996185 (ation) -450.200012207 (of) -444.3999938965 (clottin) -12.8999996185 (g) -440.799987793 (time) -452 (led) -445.5 (to) -448.1000061035 (the) -448.700012207 (hypothesis) ] TJ
0 -1.2264000177 TD
[(that) -334.8999938965 (aPEs) -334.8999938965 (might) -324.5 (be) -328.8999938965 (res) -7.9000000954 (ponsible) -337.3999938965 (for) -329.700012207 (the) -333 (L) -33.9000015259 (A) -327.5 (phe) -8.3000001907 (nomenon) -9.8999996185 (,) ] TJ
T*
[(despite) -501.799987793 (a) -496 (lack) -498 (of) -502.200012207 (a) -501.700012207 (sign) -7.5 (ificant) -498.700012207 (a) -15.8000001907 (ssociat) -10.8000001907 (ion) -496.1000061035 (between) -501.8999938965 (the) ] TJ
0 -1.220600009 TD
0.0001 Tc
[(two) -508.799987793 (a) -15.6999998093 (ssays) -507.8999938965 ([78].) -513.5999755859 (A) -495.200012207 (clear) ] TJ
/F9 1 Tf
11.1478004456 0 TD
0 Tc
[(in) -508.6000061035 (v) -10 (ivo) ] TJ
/F6 1 Tf
3.4941999912 0 TD
[(demonstratio) -16.6000003815 (n) -506.700012207 (o) 0 (f) -508 (the) ] TJ
-14.6419000626 -1.2264000177 TD
[(pathoge) -10.5 (nic) -459.200012207 (role) -457.5 (of) -455.8999938965 (aPEs) -456.3999938965 (in) -460.700012207 (mediating) -473.8999938965 (va) -14.8000001907 (scular) -460.700012207 (and) -454.299987793 (ob-) ] TJ
T*
[(stetric) -311.3999938965 (e) -10 (vent) -14.3999996185 (s) -303.3999938965 (i) 0 (s) -298 (lac) -8.8000001907 (king.) ] TJ
0.8156999946 -1.220600009 TD
[(Antib) -9.8999996185 (odies) -495 (aga) -9.6000003815 (inst) -494.200012207 (PE) -495.799987793 (have) -490.5 (bee) -9.1000003815 (n) -495.1000061035 (described) -505.700012207 (in) -495.3999938965 (up) -495.799987793 (to) ] TJ
-0.8156999946 -1.2264000177 TD
[(43%) -431.8999938965 (of) -427 (APS) -429.8999938965 (patien) -9.6000003815 (t) -13.5 (s) -20 (,) -429.8999938965 (a) -426.5 (higher) -434.700012207 (positivity) -435 (rate) -445.299987793 (compared) ] TJ
T*
[(to) -529.0999755859 (health) -10.6000003815 (y) -524.9000244141 (con) -8.3000001907 (trols) -527.200012207 ([78].) -531.0999755859 (In) -526.5999755859 (part) -8.5 (icular) 68 (,) -528.299987793 (aPE) -529 (pre) -18.1000003815 (valence) ] TJ
0 -1.220600009 TD
[(amon) -8.3000001907 (g) -585.4000244141 (women) -589.799987793 (experie) -12.3000001907 (ncing) -585.200012207 (re) -16.7999992371 (current) -591.4000244141 (pregnanc) -11.3000001907 (y) -582.700012207 (loss) ] TJ
0 -1.2264000177 TD
[(\(RPL\)) -342.799987793 (ha) -12.8000001907 (s) -332.299987793 (bee) -9.1000003815 (n) -333.1000061035 (repor) -8.1999998093 (ted) -337.200012207 (to) -338.1000061035 (range) -338 (between) -345.700012207 (23) -336.299987793 (and) -332.799987793 (31) -6.5999999046 (.7%) ] TJ
T*
[([79].) -479 (Ove) -9 (rall,) -482.1000061035 (a) 13.1000003815 (vailable) -487.799987793 (e) -15.8000001907 (vidence) -485.200012207 (on) -478.3999938965 (the) -494.8999938965 (clinical) -486 (role) -480.6000061035 (of) ] TJ
0 -1.220600009 TD
[(aPEs) -427.5 (is) -425.200012207 (inc) -7.9000000954 (onsiste) -10 (nt) -421.8999938965 (and) -431.1000061035 (comes) -428.299987793 (from) -428.1000061035 (a) -426.5 (limit) -8.8000001907 (ed) -427.799987793 (number) ] TJ
0 -1.2264000177 TD
[(of) -502.200012207 (stud) -8.6000003815 (ies) -24.5 (,) -505.1000061035 (being) -513.0999755859 (fla) -8.6000003815 (wed) -506 (by) -502.3999938965 (the) -506.5 (small) -510.799987793 (sampl) -8.5 (e) -501.700012207 (size) -507.299987793 (and) ] TJ
T*
-0.0001 Tc
[(poor) -379.700012207 (ELISA) -391.200012207 (sta) -8.8999996185 (ndardiz) -14.1999998093 (ation) -386.700012207 ([78) -6.6999998093 (]) -0.1000000015 (.) -374.1000061035 (Therefore,) -382.200012207 (aPE) -378.700012207 (testing) ] TJ
0 -1.220600009 TD
0 Tc
[(is) -298 (currently) -300.8999938965 (not) -301 (re) -11.1000003815 (comm) -10.8000001907 (ended,) -299.6000061035 (with) -297.299987793 (the) -9 (se) -296.1000061035 (autoanti) -13.8000001907 (bodies) ] TJ
0 -1.2264000177 TD
[(not) -740.700012207 (yielding) -738.299987793 (inc) -7.9000000954 (rea) -9.5 (sed) -742.799987793 (accuracy) -740.799987793 (in) -738.4000244141 (diagnosin) -11.5 (g) -735.9000244141 (APS.) ] TJ
T*
[(Ne) -13.6000003815 (verth) -9.1000003815 (eless) -25.6000003815 (,) -337.3999938965 (some) -337.299987793 (aut) -9 (hors) -336.799987793 (have) -334.299987793 (proposed) -342.6000061035 (aPE) -8.3000001907 (s) -332.299987793 (a) -15.8000001907 (s) -332.3999938965 (ser) -7.9000000954 (o-) ] TJ
0 -1.220600009 TD
[(logical) -549.299987793 (marker) -8.1000003815 (s) -540.5999755859 (o) 0 (f) -542.700012207 (seronegat) -11.8999996185 (ive) -541.5999755859 (APS) -13.3999996185 (,) -539.799987793 (a) -542.200012207 (debate) -10.8000001907 (d) -539.200012207 (noso-) ] TJ
0 -1.2264000177 TD
[(logical) -503 (entity) -502 (charact) -11.1999998093 (erized) -499.700012207 (by) -496.6000061035 (a) -496 (clinical) -503.299987793 (picture) -501.799987793 (highly) ] TJ
T*
[(sugges) -8.8000001907 (tive) -358.3999938965 (of) -357.6000061035 (APS) -360.5 (despite) -362.8999938965 (persistent) -364.8999938965 (aPL) -361.200012207 (undete) -17.7999992371 (ctabili) -12.1000003815 (ty.) ] TJ
0 -1.220600009 TD
[(In) -821.5999755859 (patie) -12 (nt) -11.1000003815 (s) -824.0999755859 (with) -823.799987793 (ot) -8.3999996185 (herwise) -828.0999755859 (unexp) -8.6000003815 (lained) -829.4000244141 (thrombotic) ] TJ
0 -1.2264000177 TD
[(e) -10 (vent) -20.2000007629 (s) -20 (,) -429.8999938965 (the) -437.1000061035 (pre) -18.1000003815 (valence) -436.200012207 (of) -438.6000061035 (aPEs) -433.200012207 (wa) -18.7999992371 (s) -430.700012207 (18%) -437.700012207 (when) -435.700012207 (dete) -17.5 (cted) ] TJ
T*
[(by) -433 (ELISA) -38.2000007629 (,) -424.1000061035 (risin) -7.6999998093 (g) -429.200012207 (t) 0 (o) -430.700012207 (30.5%) -431.299987793 (when) -435.700012207 (tested) -438.5 (using) -432.6000061035 (thin-layer) ] TJ
0 -1.220600009 TD
0.0001 Tc
[(immunos) -9.8000001907 (taining) -402.299987793 ([78,80].) -397.8999938965 (Furth) -9.1000003815 (er) 70 (,) -395.1000061035 (i) 0.1000000015 (n) -397 (a) -391.700012207 (mul) -8.8999996185 (ticenter) -403.1000061035 (study) ] TJ
0 -1.2264000177 TD
0 Tc
[(on) -328 (270) -333.8999938965 (thrombotic) -338.299987793 (patien) -9.6000003815 (t) -13.5 (s) -20 (,) -325.799987793 (6) 0 (3) -6.5999999046 (%) -327 (of) -328.700012207 (40) -330.6000061035 (aPE-po) -10.6999998093 (sitive) -332.5 (sub-) ] TJ
T*
[(je) -14.6000003815 (ct) -12 (s) -303.3999938965 (had) -303.299987793 (no) -299.1000061035 (addit) -9 (ional) -304 (aPL) -309.1000061035 (laboratory) -314.1000061035 (test) -10.8000001907 (s) -303.3999938965 ([) -2 (78].) ] TJ
/F5 1 Tf
9.2000999451 0 0 9.2000999451 304.7243041992 240.9447937012 Tm
[(Antibodies) -308.3999938965 (agai) -8.1999998093 (nst) -299.700012207 (anionic) -305.5 (ph) -7.3000001907 (ospholipids) -305.799987793 (other) -306.3999938965 (than) ] TJ
0 -1.3063999414 TD
[(cardiolip) -9.3999996185 (in) ] TJ
/F6 1 Tf
9.7999000549 0 0 9.7999000549 304.7243041992 216.9638061523 Tm
[(The) -370.799987793 (diagnostic) -390.3999938965 (and) -379.1000061035 (prognostic) -387.5 (roles) -379.1000061035 (of) -380.700012207 (se) -12.6000003815 (veral) -379.1000061035 (auto) -9.6999998093 (anti-) ] TJ
0 -1.2264000177 TD
[(bodies) -472.5 (targeting) -470.700012207 (ne) -7.5999999046 (gatively) -472.5 (charged) -470.200012207 (PL) -15.6999998093 (s) -465.3999938965 (other) -467.700012207 (than) -469.3999938965 (CL) ] TJ
T*
[(have) -386.299987793 (been) -400.1000061035 (e) -10 (valuate) -11 (d,) -390.700012207 (thoug) -9.3999996185 (h) -390.3999938965 (not) -399.3999938965 (extensively,) -405.200012207 (in) -391.299987793 (the) -396.6000061035 (set) 14.3000001907 (-) ] TJ
0 -1.220600009 TD
[(ting) -301.8999938965 (of) -305.5 (APS.) ] TJ
0.8156999946 -1.2264000177 TD
[(PS,) -555.4000244141 (ph) 13.3000001907 (o) 10.8999996185 (s) 0 (p) 13.5 (h) 0 (a) 16.1000003815 (t) 0 (i) 15.1000003815 (d) 0 (y) 17.7000007629 (l) 0 (i) 16.7000007629 (n) 0 (o) 13.3000001907 (s) 0 (i) 20.2000007629 (t) 0 (o) 14.6999998093 (l) -561.5 (an) 15.5 (d) -556.5999755859 (p) 0 (h) 13.3000001907 (o) 0 (s) 14.1000003815 (p) 0 (h) 19.1000003815 (a) 0 (t) 11.1999998093 (i) 11.1999998093 (d) 0 (i) 15.8000001907 (c) -559.5999755859 (ac) 14.6999998093 (id) 15.8000001907 (,) -563 (t) 0 (h) 18.3999996185 (r) 0 (e) 17.8999996185 (e) ] TJ
-0.8156999946 -1.2264000177 TD
[(an) 15.5 (i) 11.1999998093 (o) 0 (n) 13.3000001907 (i) 0 (c) -374.799987793 (PLs) -376.8999938965 (fo) 12.6999998093 (un) 17 (d) -383 (i) 11.1999998093 (n) -385.200012207 (t) 0 (h) 18.3999996185 (e) -386 (i) 11.1999998093 (n) 0 (n) 16.3999996185 (e) 0 (r) -375.5 (a) 0 (n) 15.5 (d) -383 (ou) 13.8999996185 (te) 16.8999996185 (r) -382.799987793 (m) 0 (e) 13.1000003815 (m) 11.5 (br) 15.6999998093 (an) 15.5 (es) -377.1000061035 (o) 10.8999996185 (f) ] TJ
0 -1.220600009 TD
[(mo) 16.6000003815 (st) -571.5 (ce) 14.6999998093 (ll) 16.7000007629 (s) -14.1999998093 (,) -580.299987793 (ar) 17.8999996185 (e) -577 (a) 0 (m) 13.1000003815 (o) 0 (n) 13.3000001907 (g) -573.9000244141 (th) 12.6000003815 (e) -577 (b) 0 (e) 12.5 (s) 0 (t) 35.9000015259 (-) 11.1000003815 (ch) 16.1000003815 (ar) 12.1000003815 (ac) 14.6999998093 (te) 16.8999996185 (ri) 16 (ze) 16.2000007629 (d) -579.700012207 (a) 0 (n) 15.5 (t) 0 (i) 20.8999996185 (g) 0 (e) 12 (n) 0 (s) 17.2000007629 (.) ] TJ
0 -1.2264000177 TD
[(No) 13.1000003815 (te) 16.8999996185 (wo) 13.6999998093 (rt) 14.3999996185 (hy) 16.1000003815 (,) -470.3999938965 (i) 11.1999998093 (n) -472 (t) 0 (h) 18.3999996185 (e) -472.799987793 (19) 16.5 (80) 16.5 (s) -471.200012207 (a) 0 (C) 13.3000001907 (L) 0 (s) -470.299987793 (w) 0 (e) 15.8999996185 (r) 0 (e) -462.299987793 (s) 0 (h) 12 (o) 10.8999996185 (wn) -463.3999938965 (to) -465.3999938965 (b) 10.8999996185 (r) 0 (o) 15.6999998093 (a) 0 (d) 11.8999996185 (l) 11.1999998093 (y) ] TJ
T*
[(cr) 17.8999996185 (os) 14.1000003815 (s-r) 13.3000001907 (ea) 14.6999998093 (ct) -428.5 (wi) 14 (th) -427.1000061035 (an) 15.5 (ti) 20.7999992371 (bo) 10.3000001907 (di) 15.8000001907 (es) -423.3999938965 (ta) 11.1999998093 (rg) 21 (et) 11.1999998093 (i) 11.1999998093 (n) 0 (g) -426.799987793 (b) 0 (o) 16 (t) 0 (h) -427.1000061035 (P) 0 (S) -432.1000061035 (a) 0 (n) 15.5 (d) -435.1000061035 (ph) 19.1000003815 (os-) ] TJ
0 -1.220600009 TD
[(ph) 13.3000001907 (at) 16.8999996185 (i) 11.1999998093 (d) 0 (y) 11.8999996185 (l) 11.1999998093 (in) 13.6999998093 (o) 10.8999996185 (s) 0 (i) 14.3999996185 (t) 0 (o) 14.6999998093 (l) 11.1999998093 (.) -701.799987793 (T) 12.3000001907 (he) -701.200012207 (cr) 12.1000003815 (o) 10.8999996185 (ss-) 11.6999998093 (re) 17.8999996185 (ac) 14.6999998093 (ti) 15.1000003815 (vi) 18 (ty) -694.5999755859 (was) -698.299987793 (mo) 16.6000003815 (st) 12.8000001907 (l) 11.1999998093 (y) -704.200012207 (su) 17.7000007629 (p-) ] TJ
0 -1.2264000177 TD
[(po) 15.5 (rt) 14.3999996185 (ed) -387.299987793 (by) -386.700012207 (th) 12.6000003815 (e) -397.6000061035 (rec) 13.6000003815 (o) 10.8999996185 (g) 0 (n) 12.8000001907 (i) 11.1999998093 (ti) 15.1000003815 (on) -391.6000061035 (o) 10.8999996185 (f) -397.3999938965 (th) 12.6000003815 (e) -403.3999938965 (c) 0 (o) 12.5 (m) 11.5 (pl) 15.8000001907 (ex) -388.799987793 (of) ] TJ
/F8 1 Tf
19.1716003418 0 TD
() Tj
/F6 1 Tf
7.3499999046 0 0 6.5324001312 497.5935974121 95.3007965088 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 501.2218933105 96.9449005127 Tm
[(GP) 16.7000007629 (I) -395.8999938965 (w) 0 (i) 14 (t) 0 (h) ] TJ
-20.0508995056 -1.2264000177 TD
[(th) 12.6000003815 (e) -443.8999938965 (d) 0 (i) 15.8000001907 (f) 0 (f) 20.8999996185 (e) 0 (r) 12.1000003815 (e) 0 (n) 15.5 (t) -441.6000061035 (an) 15.5 (io) 16.3999996185 (ni) 13.6999998093 (c) -443.8999938965 (PLs) 10.6999998093 (.) -441.5 (I) 0 (n) -439.799987793 (f) 13.3000001907 (ac) 14.6999998093 (t) -7.8000001907 (,) -441.5 (be) 12.5 (i) 11.1999998093 (n) 0 (g) -438.3999938965 (a) -443.8999938965 (ca) 14.6999998093 (ti) 15.1000003815 (o) 10.8999996185 (n) 0 (i) 13.6999998093 (c) -443.8999938965 (mo) 16.7000007629 (l-) ] TJ
0 -1.220600009 TD
[(ecu) 11.8999996185 (l) 11.1999998093 (e) 0 (,) ] TJ
/F8 1 Tf
2.7709999084 0 TD
() Tj
/F6 1 Tf
7.3499999046 0 0 6.5324001312 336.8692016602 71.3197021484 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 340.4975891113 72.9637985229 Tm
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[(GP) 16.7000007629 (I-) 14.3999996185 (de) 17.7000007629 (pe) 17.7000007629 (nd) 12.8000001907 (en) 15.5 (t) -262.299987793 (p) 0 (o) 15.5 (l) 0 (y) 12.8000001907 (c) 0 (l) 18.6000003815 (o) 0 (n) 13.3000001907 (a) 0 (l) -259.1000061035 (h) 0 (u) 17.5 (m) 0 (a) 13.1000003815 (n) -263.700012207 (Ig) 19.3999996185 (G) -267.6000061035 (b) 0 (u) 13.8999996185 (t) -268.1000061035 (no) 19.1000003815 (t) -268.1000061035 (I) 0 (g) 19.3999996185 (M) ] TJ
-2.9446001053 -1.2264000177 TD
[(aP) 14 (Ss) -244.6999969482 (i) 11.1999998093 (n) 0 (d) 12.8000001907 (u) 0 (c) 16.1000003815 (e) 0 (d) -242.6000061035 (f) 0 (e) 14.8999996185 (t) 0 (a) 11.1999998093 (l) -249.1000061035 (re) 12.1000003815 (so) 19.8999996185 (rp) 15.1000003815 (ti) 15.1000003815 (on) -247 (v) 12.6000003815 (i) 0 (a) -247.5 (t) 0 (h) 12.6000003815 (e) -253 (pr) 20.8999996185 (od) 15.5 (uc) 10.3000001907 (ti) 20.7999992371 (on) -247 (of) -247.6999969482 (mu) 14.5 (ri) 16 (ne) ] TJ
/F8 1 Tf
0 -1.220600009 TD
() Tj
/F6 1 Tf
7.3499999046 0 0 6.5324001312 61.7386016846 395.3196105957 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 65.3102035522 396.9637145996 Tm
[(GP) 16.7000007629 (I-) 14.3999996185 (de) 17.7000007629 (pe) 11.8999996185 (nd) 18.5 (en) 15.5 (t) -667.200012207 (I) 0 (g) 13.6999998093 (G) -666.799987793 (aP) 14 (S) 12.5 (s) -667.9000244141 ([) 9.6000003815 (8) 0 (3) 16.5 (]) 0 (.) -663.299987793 (D) 11.6999998093 (is) 14.3999996185 (cr) 17.8999996185 (ep) 11.8999996185 (an) 15.5 (ci) 18.6000003815 (es) -660.5 (ac) 14.6999998093 (ro) 15.6999998093 (ss) ] TJ
-0.8792999983 -1.2264000177 TD
[(a) 18.8999996185 (v) 0 (a) 14.1000003815 (i) 11.1999998093 (la) 12.8000001907 (b) 10.8999996185 (l) 0 (e) -415.299987793 (s) 0 (t) 12.8000001907 (u) 0 (d) 19.1000003815 (i) 0 (e) 12.8000001907 (s) -424.8999938965 (j) 12.8000001907 (u) 0 (s) 12 (t) 0 (i) 20.7999992371 (f) 0 (y) -419 (w) 0 (h) 17.2999992371 (y) -426.5 (AP) 20.3999996185 (S) -433 (c) 0 (r) 12.1000003815 (i) 11.1999998093 (te) 11.1999998093 (ri) 21.7999992371 (a) -426.5 (d) 0 (o) -412.6000061035 (n) 0 (o) 13.3000001907 (t) -424.299987793 (i) 11.1999998093 (n) 0 (c) 15.5 (l) 0 (u) 14.1999998093 (d) 0 (e) ] TJ
T*
[(aP) 14 (S) -259.3999938965 (ass) 13.6999998093 (ay) 14.6999998093 (s) -262.8999938965 (a) 0 (m) 13.1000003815 (o) 10.8999996185 (ng) -253.3000030518 (la) 12.8000001907 (bo) 16 (ra) 17.8999996185 (to) 14.6999998093 (ry) -254 (to) 14.6999998093 (ol) 16.3999996185 (s.) ] TJ
0.8156999946 -1.220600009 TD
[(A) -368 (novel) -377.8999938965 (ELISA) -373.700012207 (kit) -370.1000061035 (dete) -17.5 (cting) -369.700012207 (antib) -10.6000003815 (odies) -373.5 (against) -376.6000061035 (a) -368.700012207 (mix-) ] TJ
-0.8156999946 -1.2264000177 TD
[(ture) -374.5 (of) -374.8999938965 (negat) -9.1999998093 (ively) -378.3999938965 (charged) -377.6000061035 (PL) -15.6999998093 (s) -372.799987793 (comprising) -379.5 (PS) -15.6000003815 (,) -372.1000061035 (phospha-) ] TJ
T*
[(tidic) -945.299987793 (acid) -941.4000244141 (an) -7.5999999046 (d) ] TJ
/F8 1 Tf
7.8675999641 0 TD
() Tj
/F6 1 Tf
7.3499999046 0 0 6.5324001312 138.8975982666 335.3385009766 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 142.5825958252 336.9259033203 Tm
[(GPI) -946.0999755859 (\(APhL\)) -945.799987793 (ha) -12.8000001907 (s) -939.799987793 (been) -943.9000244141 (re) -16.7999992371 (cently) ] TJ
-8.7643003464 -1.220600009 TD
[(introd) -8.6000003815 (uced) -567.9000244141 (to) -563.799987793 (the) -564.4000244141 (mark) -8.6000003815 (et.) -563.4000244141 (This) -554.5999755859 (comm) -10.8000001907 (ercial) -564 (immu) -9 (no-) ] TJ
0 -1.2264000177 TD
[(a) -10 (ssay) -447.6000061035 (ha) -12.8000001907 (s) -448 (been) -446.3999938965 (sugges) -8.8000001907 (ted) -441.299987793 (to) -448.1000061035 (overco) -9.8000001907 (me) -443.8999938965 (the) -442.8999938965 (issu) -8.3000001907 (e) -443.8999938965 (o) 0 (f) -444.3999938965 (the) ] TJ
T*
[(low) -356.8999938965 (spe) -13.8000001907 (cificity) -355.200012207 (of) -351.799987793 (aCL) -20.6000003815 (s) -20 (,) -348.8999938965 (which) -360.299987793 (are) -350.799987793 (frequen) -9.3999996185 (tly) -353.6000061035 (dete) -17.5 (cted) -353 (in) ] TJ
0 -1.220600009 TD
[(infe) -17.7999992371 (ctious) -504.299987793 (conditio) -12.8000001907 (ns) -497.700012207 (such) -504.200012207 (a) -10 (s) -500.1000061035 (chronic) -508.3999938965 (hepatit) -11 (is) -494.700012207 (C) -23 (,) -499.299987793 (lep-) ] TJ
0 -1.2264000177 TD
[(rosy,) -768.200012207 (syphilis) -26 (,) -765.5 (and) -760.9000244141 (par) -35.4000015259 (voviru) -8.6000003815 (s) -760.4000244141 (B19) -761.5 (infe) -17.7999992371 (ction) -762.5999755859 (amon) -8.3000001907 (g) ] TJ
T*
[(others.) -634.0999755859 (Furth) -9.1999998093 (ermore) -11.1999998093 (,) -626.5999755859 (the) -633.799987793 (APhL) -652.5999755859 (a) -10 (ssay) -638.5 (displays) -635.799987793 (higher) ] TJ
0 -1.220600009 TD
[(positive) -334.299987793 (and) -327 (negati) -9.5 (ve) -321.3999938965 (pred) -7.6999998093 (ictive) -339.8999938965 (values) -331.3999938965 (for) -323.8999938965 (AP) -8.5 (S) -323 (diagnosis) ] TJ
0 -1.2264000177 TD
[(compa) -10.3999996185 (red) -660.200012207 (to) -667.9000244141 (two) -665.0999755859 (comme) -9.1999998093 (rcially) -668.4000244141 (a) 13.1000003815 (vail) -9.6999998093 (able) -663.200012207 (aCL) -685.9000244141 (a) -10 (ssa) -9.3999996185 (ys) ] TJ
T*
0.0001 Tc
[([84].) -409.5 (In) -405 (a) -403.299987793 (cohor) -9.3000001907 (t) -406.799987793 (o) 0.1000000015 (f) -409.5 (158) -403.200012207 (SLE) -408 (patien) -9.5 (t) -13.3999996185 (s) -19.8999996185 (,) -406.700012207 (multivaria) -14.1999998093 (te) -405.299987793 (ana-) ] TJ
0 -1.220600009 TD
0 Tc
[(lysis) -403.5 (re) -11 (vealed) -406.700012207 (an) -395.200012207 (a) -15.8000001907 (ssociati) -11.1999998093 (on) -397.3999938965 (between) -409.299987793 (APhL) -421.200012207 (and) -402.200012207 (throm-) ] TJ
0 -1.2264000177 TD
[(botic) -308.700012207 (e) -10 (vent) -14.3999996185 (s) -25.7000007629 (,) -302.700012207 (particularly) -309.5 (arteria) -11.3000001907 (l) -301.1000061035 ([) -2 (85].) ] TJ
/F5 1 Tf
9.2000999451 0 0 9.2000999451 56.6929016113 180.9638061523 Tm
[(Antibodies) -308.3999938965 (agai) -8.1999998093 (nst) -299.700012207 (vimen) -9.3999996185 (tin) ] TJ
/F6 1 Tf
9.7999000549 0 0 9.7999000549 56.6929016113 168.9447937012 Tm
[(Proteomi) -13.8999996185 (c) -796.799987793 (analysis) -802.9000244141 (of) -797.200012207 (endo) -9.5 (thelial-s) -11.5 (urface) -801.5999755859 (membra) -10.3000001907 (ne) ] TJ
T*
[(prote) -9.1000003815 (ins) -451.700012207 (in) -449.1000061035 (ser) -7.9000000954 (a) -449.700012207 (from) -457 (patient) -17.2999992371 (s) -453.799987793 (with) -453.5 (so-calle) -11.3000001907 (d) -452.5 (seronega-) ] TJ
0 -1.220600009 TD
[(tive) -323.700012207 (AP) -8.5 (S) -317.299987793 (led) -329.799987793 (to) -320.799987793 (the) -327.200012207 (identif) -9.6999998093 (ication) -327.5 (of) -357.6000061035 (viment) -9 (in) -321.8999938965 (a) -10 (s) -326.6000061035 (a) -334 (strong) ] TJ
0 -1.2264000177 TD
[(autoan) -11.5 (tigen.) -446.799987793 (Vi) -7.5 (mentin,) -449 (a) -449.700012207 (ubiquitous) -455.799987793 (cytoskele) -14.1999998093 (ton) -445.700012207 (inter) 12.1999998093 (-) ] TJ
T*
[(media) -10.1000003815 (te) -486.3999938965 (filam) -9 (ent) -489.700012207 (protein,) -494.799987793 (ha) -12.8000001907 (s) -488.5 (been) -492.700012207 (show) -9.1000003815 (n) -483.5 (t) 0 (o) -488.6000061035 (bind) -491.5 (CL) ] TJ
/F9 1 Tf
0 -1.220600009 TD
[(in) -531.700012207 (v) -15.8000001907 (itro) ] TJ
/F6 1 Tf
3.2685000896 0 TD
[(.) -528.299987793 (I) 0 (n) -538.0999755859 (one) -546.299987793 (cohort) -537.799987793 (of) -536.9000244141 (patien) -9.6000003815 (t) -7.6999998093 (s) -25.7000007629 (,) -534.0999755859 (antibodies) -540.299987793 (aga) -9.6000003815 (inst) ] TJ
-3.2685000896 -1.2264000177 TD
[(viment) -9 (in/CL) -344.5 (were) -342.200012207 (describe) -12.8000001907 (d) -336.799987793 (i) 0 (n) -339.200012207 (5) 0 (5) -6.5999999046 (%) -338.5 (of) -340.200012207 (serone) -10.3000001907 (gative) -346.5 (APS) ] TJ
T*
[(and) -350.1000061035 (92%) -350.8999938965 (of) -346 (full-blow) -12.6000003815 (n) -344.700012207 (APS) -348.8999938965 (patie) -12 (nt) -11.1000003815 (s) -343.8999938965 ([) -2 (82].) -351.700012207 (Howe) -18.8999996185 (ver) 70.9000015259 (,) -348.8999938965 (anti-) ] TJ
0 -1.220600009 TD
[(bodies) -455.200012207 (agains) -10.1000003815 (t) -447.3999938965 (vime) -9.3999996185 (ntin/CL) -453.8999938965 (have) -444.200012207 (also) -453.299987793 (been) -457.8999938965 (reported) -455.299987793 (in) ] TJ
0 -1.2264000177 TD
[(aPL-) -8.8000001907 (negative) -782.200012207 (SLE) -784.200012207 (and) -778.200012207 (rheuma) -9.3999996185 (toid) -773.5999755859 (arthritis) -785.700012207 (subje) -14.8000001907 (ct) -12 (s) ] TJ
25.3094997406 64.8964004517 TD
[(withou) -11.5 (t) -592 (any) -596.0999755859 (clin) -8.3000001907 (ical) -593.4000244141 (man) -7.6999998093 (ifestation) -602.200012207 (sugg) -7.6999998093 (estive) -602.5 (of) -594.799987793 (APS) -13.3999996185 (,) ] TJ
0 -1.220600009 TD
[(thus) -698.5999755859 (weakeni) -11.1000003815 (ng) -692.9000244141 (the) -691.5999755859 (spe) -19.6000003815 (cificity) -696.5999755859 (of) -698.9000244141 (such) -695.0999755859 (a) -692.5999755859 (diagno) -11 (stic) ] TJ
0 -1.2264000177 TD
0.0002 Tc
[(marker) -308.700012207 ([82].) ] TJ
/F5 1 Tf
9.2000999451 0 0 9.2000999451 304.7243041992 648.9636230469 Tm
0 Tc
[(Annex) -8.8000001907 (ins:) -299.200012207 (annex) -8.3000001907 (in) -297.200012207 (A5) -306.799987793 (resistance) -307.5 (assay) -305.3999938965 (and) ] TJ
0 -1.3063999414 TD
[(autoan) -9 (tibodies) -303.700012207 (agains) -10 (t) -297.8999938965 (annex) -8.3000001907 (in) -297.200012207 (A5) -306.799987793 (and) -300.8999938965 (annex) -8.3000001907 (in) -297.200012207 (A2) ] TJ
/F6 1 Tf
9.7999000549 0 0 9.7999000549 304.7243041992 624.92578125 Tm
[(Annexin) -9.3999996185 (s) -401.799987793 (are) -402.8999938965 (a) -403.3999938965 (f) 0 (a) -8.3000001907 (mily) -404.1000061035 (of) -403.8999938965 (ubiquit) -10.1000003815 (ous) -405.200012207 (calciu) -10.3999996185 (m-depend) -10.3000001907 (ent) ] TJ
0 -1.220600009 TD
[(PL-bin) -8.8999996185 (ding) -376.299987793 (proteins.) -381.700012207 (Annexin) -379.6000061035 (\(Ann\)A5) -379.799987793 (is) -373.200012207 (a) -368.700012207 (poten) -11.5 (t) -372.200012207 (anti-) ] TJ
0 -1.2264000177 TD
[(coagula) -11.8999996185 (nt) -340.8999938965 (prote) -9.1000003815 (in) -339.200012207 (main) -8 (ly) -340.1000061035 (found) -347.6000061035 (in) -339.200012207 (trophobla) -25.1000003815 (st) -10.3000001907 (s) -343.8999938965 (and) -344.3999938965 (va) -9 (s) -14.1999998093 (-) ] TJ
T*
[(cular) -492.799987793 (ECs) -7.4000000954 (.) -487.799987793 (Upo) -7.5999999046 (n) -489.299987793 (binding) -496.3999938965 (to) -488.6000061035 (an) -7.5999999046 (ionic) -494.8999938965 (PL) -9.8999996185 (s) -25.7000007629 (,) -487.799987793 (it) -488.200012207 (und) -7.4000000954 (ergoes) ] TJ
0 -1.220600009 TD
[(oligo) -8.8999996185 (meriz) -14.1000003815 (ation) -461.799987793 (to) -465.3999938965 (form) -462.799987793 (a) -455.5 (prote) -20.7000007629 (ctive) -461 (shield) -462.799987793 (agai) -10 (nst) -459.200012207 (co-) ] TJ
0 -1.2264000177 TD
[(agulation) -638.0999755859 (enzy) -8.6999998093 (mes.) ] TJ
/F8 1 Tf
8.8741998672 0 TD
() Tj
/F6 1 Tf
7.3499999046 0 0 6.5324001312 396.7936096191 563.3007202148 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 400.4786071777 564.9448242188 Tm
[(GPI-de) -9.1000003815 (pendent) -638.5999755859 (aPL) -14.1000003815 (s) -627.4000244141 (h) 0 (a) 10.3000001907 (v) 0 (e) -633.799987793 (been) ] TJ
-9.7708997726 -1.2264000177 TD
[(show) -9.1000003815 (n) -310 (t) 0 (o) -315 (interf) -9.1999998093 (ere) -310.299987793 (with) -320.5 (the) -315.6000061035 (prote) -14.8999996185 (ctive) -322.200012207 (binding) -317.1000061035 (of) -317.1000061035 (AnnA5) ] TJ
0 -1.220600009 TD
[(to) -621.5999755859 (the) -628 (endothelium) -16.2000007629 (,) -620.799987793 (hence) -626.299987793 (leading) -628.0999755859 (to) -621.5999755859 (thrombo) -13.6000003815 (sis.) -620.5999755859 (A) ] TJ
0 -1.2264000177 TD
[(novel) -829.0999755859 (two-st) -10.6999998093 (age) -836.9000244141 (coagulatio) -14.8000001907 (n) -819 (a) -15.8000001907 (ssay) -823.5999755859 (to) -829.9000244141 (establis) -11.1999998093 (h) -824.299987793 (the) ] TJ
T*
[(AnnA) -8.1000003815 (5) -362 (resistance) -370.200012207 (ha) -18.6000003815 (s) -361.299987793 (been) -365.3999938965 (de) -17 (velope) -9.6999998093 (d;) -361.700012207 (patien) -9.6000003815 (t) -7.6999998093 (s) -367.1000061035 (with) -366.799987793 (co-) ] TJ
0 -1.220600009 TD
[(agulation) -447.200012207 (time) -440.5 (lower) -437.299987793 (than) -440.5 (the) -437.1000061035 (refer) -8.8000001907 (ence) -438.3999938965 (are) -449.200012207 (considered) ] TJ
0 -1.2264000177 TD
-0.0001 Tc
[(AnnA) -8.1999998093 (5-resistant) -367.5 ([81) -6.6999998093 (,) -1.8999999762 (82].) -357.6000061035 (Data) -357.6000061035 (from) -364.5 (five) -354.799987793 (stud) -8.6999998093 (ies) -360.200012207 (re) -11.1999998093 (vealed) ] TJ
T*
0 Tc
[(that) -323.3999938965 (52) -6.5999999046 (%) -321.200012207 (o) 0 (f) -317.1000061035 (A) 0 (P) -8.5 (S) -317.299987793 (patien) -9.6000003815 (t) -13.5 (s) -320.799987793 (were) -324.8999938965 (AnnA5-resis) -11.1000003815 (tant) -17.2999992371 (,) -320 (i) 0 (n) -321.8999938965 (com-) ] TJ
0 -1.220600009 TD
[(pariso) -10.1000003815 (n) -408.299987793 (with) -418.799987793 (2) -414 (t) 0 (o) -413.3999938965 (5) 0 (%) -411.200012207 (o) 0 (f) -415.3999938965 (con) -8.3000001907 (trols) -417.299987793 (and) -413.799987793 (seronegat) -11.8999996185 (ive) -414.299987793 (sub-) ] TJ
0 -1.2264000177 TD
[(je) -14.6000003815 (ct) -12 (s) -558 ([) -2 (81].) -560 (Resistance) -570.799987793 (to) -558 (AnnA) -8.1000003815 (5) -552.9000244141 (anticoa) -13.1999998093 (gulant) -563.4000244141 (activity) ] TJ
T*
[(wa) -13 (s) -390.200012207 (found) -388.1000061035 (to) -390.200012207 (inver) -8 (sely) -387.3999938965 (corre) -11.1999998093 (late) -386.799987793 (with) -395.700012207 (titers) -393.8999938965 (of) -386.5 (IgG) -387 (an) -7.5999999046 (ti-) ] TJ
0 -1.220600009 TD
[(bodies) -565.0999755859 (targeting) -563.299987793 (DI) -563.5999755859 (in) -553.299987793 (bot) -9.1000003815 (h) -552.4000244141 (throm) -12.3000001907 (botic) -563.200012207 (and) -558.4000244141 (obstetric) ] TJ
0 -1.2264000177 TD
[(APS) -447.299987793 ([81].) -450.1000061035 (Futur) -9.3000001907 (e) -443.8999938965 (studi) -8.8999996185 (es) -446.5 (will) -449.3999938965 (a) -10 (ssess) -448.5 (whe) -10 (ther) -449.700012207 (this) -447.3999938965 (func-) ] TJ
T*
[(tional) -305.8999938965 (test) -300 (may) -303.6000061035 (allow) -303.6000061035 (the) -304 (identif) -9.6999998093 (ication) -304.3999938965 (of) -299.700012207 (spe) -19.6000003815 (cific) -302.3999938965 (subset) -20.7000007629 (s) ] TJ
0 -1.220600009 TD
[(of) -346 (patho) -10.8999996185 (genic) -348.8999938965 (anti-) ] TJ
/F8 1 Tf
8.0122995377 0 TD
() Tj
/F6 1 Tf
7.3499999046 0 0 6.5324001312 388.3464050293 395.3196105957 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 392.0314025879 396.9637145996 Tm
[(GPI) -350.299987793 (antibo) -11.1999998093 (dies.) -345.799987793 (The) -347.6000061035 (clin) -8.3000001907 (ical) -350.3999938965 (signifi-) ] TJ
-8.9089002609 -1.2264000177 TD
[(cance) -448.3999938965 (of) -444.3999938965 (serum) -450.3999938965 (autoantibo) -15.1000003815 (dies) -442.299987793 (agains) -10.1999998093 (t) -441.6000061035 (AnnA5) -445.299987793 (ha) -12.8000001907 (s) -442.299987793 (also) ] TJ
T*
[(been) -452.200012207 (inves) -9.6000003815 (tigated:) -456.6000061035 (in) -449.1000061035 (one) -447.8999938965 (stud) -8.6000003815 (y,) -451.5 (no) -449.5 (a) -10 (ssociat) -10.8000001907 (ion) -449.799987793 (wa) -13 (s) -448 (re-) ] TJ
0 -1.220600009 TD
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0 -1.2264000177 TD
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(t) Tj
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55.4460983276 0 TD
[(factor) -13.8999996185 (.) ] TJ
/F2 1 Tf
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(Meroni) Tj
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[(et) -296.8999938965 (al.) -301.299987793 (Arthritis) -296.1000061035 (Research) -291.1000061035 (&) -302.799987793 (Therapy) ] TJ
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[(Page) -297.8999938965 (10) -298.1000061035 (of) -294.799987793 (14) ] TJ
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