An Italian 13-year-old boy immunosuppressed due to kidney transplant presented in November 2018 with acute flaccid paralysis with anterior horn cell involvement resembling the clinical, radiological, and laboratory features of poliomyelitis. Enterovirus was molecularly identified in cerebral spinal fluid and stool samples and the sequence analysis of the VP1 gene of enterovirus genome revealed the presence of Echovirus 30 both in CSF and in stool samples. Echovirus 30 is an emerging neurotropic virus able to cause outbreaks of aseptic meningitis and meningoencephalitis all over the world, but acute flaccid paralysis is not a classical manifestation. A 6-month follow-up revealed a poor outcome with severe motor deficits and only slight improvement in disability. Clinicians must be aware of the possible role of Echovirus 30 in acute flaccid paralysis and active surveillance should consider the possible influence of immunosuppression on the symptoms caused by the widening spectrum of enterovirus infections.

Acute flaccid paralysis due to Echovirus 30 in an immunosuppressed transplant recipient / E. Mauri, A. Mastrangelo, S. Testa, L. Pellegrinelli, E. Pariani, S. Binda, F. Triulzi, S. Barbieri, C. Bana, G. Montini, R. Dilena. - In: JOURNAL OF NEUROVIROLOGY. - ISSN 1355-0284. - 26:2(2020 Apr), pp. 284-288. [10.1007/s13365-019-00812-4]

Acute flaccid paralysis due to Echovirus 30 in an immunosuppressed transplant recipient

L. Pellegrinelli;E. Pariani;S. Binda;F. Triulzi;G. Montini
Penultimo
;
2020

Abstract

An Italian 13-year-old boy immunosuppressed due to kidney transplant presented in November 2018 with acute flaccid paralysis with anterior horn cell involvement resembling the clinical, radiological, and laboratory features of poliomyelitis. Enterovirus was molecularly identified in cerebral spinal fluid and stool samples and the sequence analysis of the VP1 gene of enterovirus genome revealed the presence of Echovirus 30 both in CSF and in stool samples. Echovirus 30 is an emerging neurotropic virus able to cause outbreaks of aseptic meningitis and meningoencephalitis all over the world, but acute flaccid paralysis is not a classical manifestation. A 6-month follow-up revealed a poor outcome with severe motor deficits and only slight improvement in disability. Clinicians must be aware of the possible role of Echovirus 30 in acute flaccid paralysis and active surveillance should consider the possible influence of immunosuppression on the symptoms caused by the widening spectrum of enterovirus infections.
Anterior horn cell disease; EMG; Epidemiology; MRI; Viral infections
Settore MED/38 - Pediatria Generale e Specialistica
apr-2020
22-ott-2019
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/970114
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