Fourteen cases of sarcomatoid carcinomas of breast were evaluated by means of a silver technique that selectively stains proteins located in the nucleolar organizer regions (Ag-NORs). The mean area of Ag-NORs (MNORA) was in each case quantitatively analyzed by means of an automated image analyzer. Patients who died early of the disease had a higher MNORA than patients who survived longer than 3 years. The difference was statistically significant. Ag-NORs might be a novel parameter of prognostic relevance in specific cases.
Prognostic relevance of silver-stained nucleolar proteins in sarcomatoid carcinomas of the breast / V. Eusebi, M.G. Cattani, J. Lamovec, D. Trere, C. Ceccarelli, P. Veronesi, C. Clemente, M. Derenzini. - In: ULTRASTRUCTURAL PATHOLOGY. - ISSN 0191-3123. - 15:3(1991 May), pp. 203-214. [10.3109/01913129109021882]
Prognostic relevance of silver-stained nucleolar proteins in sarcomatoid carcinomas of the breast
P. Veronesi;C. Clemente;
1991
Abstract
Fourteen cases of sarcomatoid carcinomas of breast were evaluated by means of a silver technique that selectively stains proteins located in the nucleolar organizer regions (Ag-NORs). The mean area of Ag-NORs (MNORA) was in each case quantitatively analyzed by means of an automated image analyzer. Patients who died early of the disease had a higher MNORA than patients who survived longer than 3 years. The difference was statistically significant. Ag-NORs might be a novel parameter of prognostic relevance in specific cases.
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