The preparation of 7R-HMR (allo-hydroxymatairesinol) is reported by: (a) NaBH4 kinetic reduction of 7R/7S diastereomeric mixture; and (b) epimerization of the C7 hydroxyl group by Mitsunobu reaction and subsequent ester hydrolysis. The availability of highly pure target compound (7R-HMR) made it possible to confirm the structure of the target compound and to complete the full spectroscopic characterization.
Convenient preparation and spectroscopic characterization of 7r-hydroxymatairesinol / E. Colombo, G. Paladino, U. Ciriello, D. Passarella. - In: MOLECULES. - ISSN 1420-3049. - 26:19(2021 Sep 26), pp. 5838.1-5838.9. [10.3390/molecules26195838]
Convenient preparation and spectroscopic characterization of 7r-hydroxymatairesinol
E. ColomboPrimo
;D. Passarella
Ultimo
2021
Abstract
The preparation of 7R-HMR (allo-hydroxymatairesinol) is reported by: (a) NaBH4 kinetic reduction of 7R/7S diastereomeric mixture; and (b) epimerization of the C7 hydroxyl group by Mitsunobu reaction and subsequent ester hydrolysis. The availability of highly pure target compound (7R-HMR) made it possible to confirm the structure of the target compound and to complete the full spectroscopic characterization.
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