The molecular pathophysiology of cardiometabolic diseases is known to be influenced by dysfunctional ectopic adipose tissue. In addition to lifestyle improvements, these conditions may be managed by novel nutraceutical products. This study evaluatedthe effects of 11 Cameroonian medicinal spice extracts on triglyceride accumulation, glucose uptake, reactive oxygen species (ROS) production and interleukin secretion in SW 872 human adipocytes after differentiation with 100 μM oleic acid. Triglyceride content was significantly reduced by all spice extracts. Glucose uptake was significantly increased by Tetrapleura tetraptera, Aframomum melegueta and Zanthoxylum leprieurii. Moreover, Xylopia parviflora, Echinops giganteus and Dichrostachys glomerata significantly reduced the production of ROS. Concerning pro‐inflammatory cytokine secretion, we observed that Tetrapleura tetraptera, Echinops giganteus, Dichrostachys glomerata and Aframomum melegueta reduced IL‐6 secretion. In addition, Xylopia parviflora, Monodora myristica, Zanthoxylum leprieurii, and Xylopia aethiopica reduced IL‐8 secretion, while Dichrostachys glomerata and Aframomum citratum increased it. These findings highlight some interesting properties of these Cameroonian spice extracts in the modulation of cellular parameters relevant to cardiometabolic diseases, which may be further exploited, aiming to develop novel treatment options for these conditions based on nutraceutical products.

Cameroonian spice extracts modulate molecular mechanisms relevant to cardiometabolic diseases in sw 872 human liposarcoma cells / A.P. Atchan Nwakiban, A. Passarelli, L. Da Dalt, C. Olivieri, T.N. Demirci, S. Piazza, E. Sangiovanni, E. Carpentier-maguire, G. Martinelli, S.T. Shivashankara, U.V. Manjappara, A.D. Tchamgoue, G.A. Agbor, J.-. Kuiate, M. Daglia, M. Dell'agli, P. Magni. - In: NUTRIENTS. - ISSN 2072-6643. - 13:12(2021 Nov 26), pp. 4271.1-4271.15. [10.3390/nu13124271]

Cameroonian spice extracts modulate molecular mechanisms relevant to cardiometabolic diseases in sw 872 human liposarcoma cells

A. Passarelli
Co-primo
;
L. Da Dalt
Secondo
;
T.N. Demirci;S. Piazza;E. Sangiovanni;G. Martinelli;M. Dell'Agli
Penultimo
;
P. Magni
Ultimo
2021

Abstract

The molecular pathophysiology of cardiometabolic diseases is known to be influenced by dysfunctional ectopic adipose tissue. In addition to lifestyle improvements, these conditions may be managed by novel nutraceutical products. This study evaluatedthe effects of 11 Cameroonian medicinal spice extracts on triglyceride accumulation, glucose uptake, reactive oxygen species (ROS) production and interleukin secretion in SW 872 human adipocytes after differentiation with 100 μM oleic acid. Triglyceride content was significantly reduced by all spice extracts. Glucose uptake was significantly increased by Tetrapleura tetraptera, Aframomum melegueta and Zanthoxylum leprieurii. Moreover, Xylopia parviflora, Echinops giganteus and Dichrostachys glomerata significantly reduced the production of ROS. Concerning pro‐inflammatory cytokine secretion, we observed that Tetrapleura tetraptera, Echinops giganteus, Dichrostachys glomerata and Aframomum melegueta reduced IL‐6 secretion. In addition, Xylopia parviflora, Monodora myristica, Zanthoxylum leprieurii, and Xylopia aethiopica reduced IL‐8 secretion, while Dichrostachys glomerata and Aframomum citratum increased it. These findings highlight some interesting properties of these Cameroonian spice extracts in the modulation of cellular parameters relevant to cardiometabolic diseases, which may be further exploited, aiming to develop novel treatment options for these conditions based on nutraceutical products.
Cameroonian spice extracts; glucose uptake; oxidative stress; pro‐inflammatory cytokines; SW 872 adipocytes; triglyceride accumulation
Settore MED/04 - Patologia Generale
Settore MED/13 - Endocrinologia
Settore BIO/14 - Farmacologia
   PIANO DI SOSTEGNO ALLA RICERCA 2015-2017 - TRANSITION GRANT LINEA 1A PROGETTO "UNIMI PARTENARIATI H2020" (anno 2020)
   UNIVERSITA' DEGLI STUDI DI MILANO
26-nov-2021
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/887308
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