Many labeled compounds are used as radiopharmaceuticals (RP), for emission imaging and metabolic radiotherapy and contain as labeling agents γ, β-, β+, monochromatic e- and α emitting radionuclides (RN). These labeled compounds very often contain unexpected radionuclidic impurities. Some long-lived isotopic and non-isotopic impurities lead to undesirable radiation doses to the patient and his relatives, as well as to medical/paramedical personnel, other than the general population, due to rad-waste of contaminated specimen and excretion of biological fluids. Use was made of liquid scintillation counting/spectrometry (LSCS) for the detection of tiny amounts of charged particle emitting impurities in RPs labeled with 64Cu, 67Ga, 90Y, 90Sr/ 90Y, 123I, 153Sm, 177Lu and 201Tl.
The use of liquid scintillation counting as a very sensitive radioanalytical tool for the determination of alpha, beta and electron emitting impurities in radiopharmaceutical compounds / F. Groppi, H.S. Mainardi, A. Martinotti, S. Morzenti, M.L. Bonardi. - In: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY. - ISSN 0236-5731. - 263:2(2005 Jan), pp. 521-525.
The use of liquid scintillation counting as a very sensitive radioanalytical tool for the determination of alpha, beta and electron emitting impurities in radiopharmaceutical compounds
F. GroppiPrimo
;H.S. MainardiSecondo
;A. Martinotti;S. MorzentiPenultimo
;M.L. BonardiUltimo
2005
Abstract
Many labeled compounds are used as radiopharmaceuticals (RP), for emission imaging and metabolic radiotherapy and contain as labeling agents γ, β-, β+, monochromatic e- and α emitting radionuclides (RN). These labeled compounds very often contain unexpected radionuclidic impurities. Some long-lived isotopic and non-isotopic impurities lead to undesirable radiation doses to the patient and his relatives, as well as to medical/paramedical personnel, other than the general population, due to rad-waste of contaminated specimen and excretion of biological fluids. Use was made of liquid scintillation counting/spectrometry (LSCS) for the detection of tiny amounts of charged particle emitting impurities in RPs labeled with 64Cu, 67Ga, 90Y, 90Sr/ 90Y, 123I, 153Sm, 177Lu and 201Tl.Pubblicazioni consigliate
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