The hydrolysis of (RS)-isopropylideneglycerol acetate with whole cells of the yeast Kluyveromyces marxianus is reported. The biotransformation furnished (R)-isopropylideneglycerol as major enantiomer with good enantioselectivity (E ¼ 28) under optimised conditions. The reaction can be performed in an ultrafiltration-membrane reactor allowing for the obtainment of 19.2 g/L of enantiomerically pure (R)-isopropylideneglycerol acetate starting from 60 g/L of racemic mixture.
Enantioselective hydrolysis of (RS)-isopropylideneglycerol acetate with Kluyveromyces marxianus / F. Molinari, K.S. Cavenago, A. Romano, D. Romano, R. Gandolfi. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 15:12(2004), pp. 1945-1947. [10.1016/j.tetasy.2004.05.010]
Enantioselective hydrolysis of (RS)-isopropylideneglycerol acetate with Kluyveromyces marxianus
F. MolinariPrimo
;A. Romano;D. RomanoPenultimo
;R. GandolfiUltimo
2004
Abstract
The hydrolysis of (RS)-isopropylideneglycerol acetate with whole cells of the yeast Kluyveromyces marxianus is reported. The biotransformation furnished (R)-isopropylideneglycerol as major enantiomer with good enantioselectivity (E ¼ 28) under optimised conditions. The reaction can be performed in an ultrafiltration-membrane reactor allowing for the obtainment of 19.2 g/L of enantiomerically pure (R)-isopropylideneglycerol acetate starting from 60 g/L of racemic mixture.
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