An interaction between metabolic glucose impairment and coronavirus disease 2019 is reported. The development of a severe multisystem inflammatory syndrome in children (MIS-C) related to SARS-CoV-2 infection has been described. We evaluated the impact of MIS-C on glycemic patterns in pediatric patients. A group of 30 children and adolescents affected by MIS-C were considered; all patients were normal weight. Clinical and biochemical assessments, including surrogate markers of insulin resistance (IR) such as homeostasis model analysis-IR (HOMA-IR) and triglyceride-glucose (TyG) indexes, were recorded. Patients were also invited to undergo an intermittently scanned continuous glucose monitoring (isCGM). HOMA-IR index was calculated in 18 patients (60%), of which 17 (94%) revealed a pathological value. TyG index was computed for all patients and pathological values were detected in all cases. In 15 patients, isCGM data were recorded on average for 9 days (+/- 3 days). Overall, average glucose was 105 mg/dL (+/- 16 mg/dL) and average time spent in the 70-180 mg/dL range (TIR) was 93.76%, with nearly 10% of glucose readings in the 141-180 mg/dL range; glycemic fluctuations over the hyperglycemic threshold were detected in four patients. Regular glucose monitoring may be useful to prevent metabolic imbalance and obtain a better outcome.

Impaired Glucose-Insulin Metabolism in Multisystem Inflammatory Syndrome Related to {SARS}-{CoV}-2 in Children / V. Calcaterra, P. Bosoni, D. Dilillo, S. Mannarino, L. Fiori, V. Fabiano, P. Carlucci, E. Di Profio, E. Verduci, C. Mameli, G. Pelizzo, E. Zoia, L. Sacchi, C. Larizza, G. Zuccotti. - In: CHILDREN. - ISSN 2227-9067. - 8:5(2021 May). [10.3390/children8050384]

Impaired Glucose-Insulin Metabolism in Multisystem Inflammatory Syndrome Related to {SARS}-{CoV}-2 in Children

V. Fabiano;E. DI PROFIO;E. Verduci;C. Mameli;G. Pelizzo;G.V. Zuccotti
2021

Abstract

An interaction between metabolic glucose impairment and coronavirus disease 2019 is reported. The development of a severe multisystem inflammatory syndrome in children (MIS-C) related to SARS-CoV-2 infection has been described. We evaluated the impact of MIS-C on glycemic patterns in pediatric patients. A group of 30 children and adolescents affected by MIS-C were considered; all patients were normal weight. Clinical and biochemical assessments, including surrogate markers of insulin resistance (IR) such as homeostasis model analysis-IR (HOMA-IR) and triglyceride-glucose (TyG) indexes, were recorded. Patients were also invited to undergo an intermittently scanned continuous glucose monitoring (isCGM). HOMA-IR index was calculated in 18 patients (60%), of which 17 (94%) revealed a pathological value. TyG index was computed for all patients and pathological values were detected in all cases. In 15 patients, isCGM data were recorded on average for 9 days (+/- 3 days). Overall, average glucose was 105 mg/dL (+/- 16 mg/dL) and average time spent in the 70-180 mg/dL range (TIR) was 93.76%, with nearly 10% of glucose readings in the 141-180 mg/dL range; glycemic fluctuations over the hyperglycemic threshold were detected in four patients. Regular glucose monitoring may be useful to prevent metabolic imbalance and obtain a better outcome.
multisystem inflammatory syndrome; SARS-CoV-2; glucose; insulin; children;
Settore MED/38 - Pediatria Generale e Specialistica
mag-2021
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/843996
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