Disorders of the ventral induction give rise to a group of congenital malformations that share in common the failure of the prosencephalon cleavage and subsequent formation of midline structures, presenting with a wide spectrum of severity. This article focuses on the imaging findings of the holoprosencephaly spectrum and septo-optic dysplasia, their epidemiology, embryology, and the common clinical associated anomalies. Knowledge of the imaging features of these disorders is necessary for a correct interpretation of findings and accurate parental counseling. Diagnostic evaluation of patients should include molecular screening and genetic counseling to characterize prognosis and risk of recurrence.
Disorders of Ventral Induction/Spectrum of Holoprosencephaly / S.F. Calloni, L. Caschera, F.M. Triulzi. - In: NEUROIMAGING CLINICS OF NORTH AMERICA. - ISSN 1052-5149. - 29:3(2019), pp. 411-421.
|Titolo:||Disorders of Ventral Induction/Spectrum of Holoprosencephaly|
|Parole Chiave:||Brain; Holoprosencephaly; Magnetic resonance; Neurodevelopment; Syntelencephaly; Ventral induction; Brain; Holoprosencephaly; Humans; Magnetic Resonance Imaging|
|Settore Scientifico Disciplinare:||Settore MED/37 - Neuroradiologia|
|Data di pubblicazione:||2019|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.nic.2019.03.003|
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