COVID-19 is increasingly understood as a systemic disease with pathogenic manifestations beyond the respiratory tract. Recent work by Ramani et al (2020) dissects the cellular and molecular mechanisms of SARS-CoV-2’s neurotrophic properties, using viral exposure of human brain organoids. Their findings highlight neurons as primary target of cerebral SARS-CoV-2 infection and uncover its Tau-related neurotoxicity.
COVID-19 lessons from the dish: Dissecting CNS manifestations through brain organoids / N. Caporale, G. Testa. - In: EMBO JOURNAL. - ISSN 0261-4189. - (2020 Dec 02). [Epub ahead of print] [10.15252/embj.2020107213]
COVID-19 lessons from the dish: Dissecting CNS manifestations through brain organoids
N. Caporale
;G. Testa
2020
Abstract
COVID-19 is increasingly understood as a systemic disease with pathogenic manifestations beyond the respiratory tract. Recent work by Ramani et al (2020) dissects the cellular and molecular mechanisms of SARS-CoV-2’s neurotrophic properties, using viral exposure of human brain organoids. Their findings highlight neurons as primary target of cerebral SARS-CoV-2 infection and uncover its Tau-related neurotoxicity.
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