The severity of coronavirus disease 2019 (COVID-19) is a crucial problem in patient treatment and outcome. The aim of this study is to evaluate circulating level of sphingosine-1-phosphate (S1P) along with severity markers, in COVID-19 patients. One hundred eleven COVID-19 patients and forty-seven healthy subjects were included. The severity of COVID-19 was found significantly associated with anemia, lymphocytopenia, and significant increase of neutrophil-to-lymphocyte ratio, ferritin, fibrinogen, aminotransferases, lactate dehydrogenase (LDH), C-reactive protein (CRP), and D-dimer. Serum S1P level was inversely associated with COVID-19 severity, being significantly correlated with CRP, LDH, ferritin, and D-dimer. The decrease in S1P was strongly associated with the number of erythrocytes, the major source of plasma S1P, and both apolipoprotein M and albumin, the major transporters of blood S1P. Not last, S1P was found to be a relevant predictor of admission to an intensive care unit, and patient's outcome. Circulating S1P emerged as negative biomarker of severity/mortality of COVID-19 patients. Restoring abnormal S1P levels to a normal range may have the potential to be a therapeutic target in patients with COVID-19.

Decreased serum level of sphingosine-1-phosphate: a novel predictor of clinical severity in COVID-19 / G. Marfia, S. Navone, L. Guarnaccia, R. Campanella, M. Mondoni, M. Locatelli, A. Barassi, L. Fontana, F. Palumbo, E. Garzia, G. Ciniglio Appiani, D. Chiumello, M. Miozzo, S. Centanni, L. Riboni. - In: EMBO MOLECULAR MEDICINE. - ISSN 1757-4676. - (2020 Nov 14). [Epub ahead of print]

Decreased serum level of sphingosine-1-phosphate: a novel predictor of clinical severity in COVID-19

Marfia, Giovanni;Navone, Stefania;Guarnaccia, Laura;Mondoni, Michele;Locatelli, Marco;Barassi, Alessandra;Fontana, Laura;Garzia, Emanuele;Chiumello, Davide;Miozzo, Monica;Centanni, Stefano;Riboni, Laura
2020-11-14

Abstract

The severity of coronavirus disease 2019 (COVID-19) is a crucial problem in patient treatment and outcome. The aim of this study is to evaluate circulating level of sphingosine-1-phosphate (S1P) along with severity markers, in COVID-19 patients. One hundred eleven COVID-19 patients and forty-seven healthy subjects were included. The severity of COVID-19 was found significantly associated with anemia, lymphocytopenia, and significant increase of neutrophil-to-lymphocyte ratio, ferritin, fibrinogen, aminotransferases, lactate dehydrogenase (LDH), C-reactive protein (CRP), and D-dimer. Serum S1P level was inversely associated with COVID-19 severity, being significantly correlated with CRP, LDH, ferritin, and D-dimer. The decrease in S1P was strongly associated with the number of erythrocytes, the major source of plasma S1P, and both apolipoprotein M and albumin, the major transporters of blood S1P. Not last, S1P was found to be a relevant predictor of admission to an intensive care unit, and patient's outcome. Circulating S1P emerged as negative biomarker of severity/mortality of COVID-19 patients. Restoring abnormal S1P levels to a normal range may have the potential to be a therapeutic target in patients with COVID-19.
COVID-19; Coronavirus; intensive care unit; prognostic biomarker; sphingosine-1-phosphate
Settore MED/27 - Neurochirurgia
Settore BIO/10 - Biochimica
Settore MED/41 - Anestesiologia
Settore MED/10 - Malattie dell'Apparato Respiratorio
Settore BIO/18 - Genetica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/797803
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