Metabolic dysfunction and fatty liver disease (FLD) are epidemiologically associated with increased risk of severe COVID-19 requiring hospitalization (1, 2). The mechanism may encompass promotion of inflammation by facilitation of liver injury, which is a frequent feature of severe COVID-19 (3). However, metabolic dysfunction rather than FLD itself may induce disease progression (2). Indeed, we previously showed that a genetic FLD-risk score does not predispose to severe COVID-19 in UK Biobank population-based cohort (UKBB) (4).
Genetic insight into Covid-19 related liver injury / C. Bianco, G. Baselli, F. Malvestiti, L. Santoro, S. Pelusi, M. Manunta, G. Grasselli, A. Bandera, L. Scudeller, D. Prati, L. Valenti. - In: LIVER INTERNATIONAL. - ISSN 1478-3223. - (2020). [Epub ahead of print] [10.1111/liv.14708]
Genetic insight into Covid-19 related liver injury
G. Baselli;F. Malvestiti;S. Pelusi;G. Grasselli;A. Bandera;L. Valenti
Ultimo
2020
Abstract
Metabolic dysfunction and fatty liver disease (FLD) are epidemiologically associated with increased risk of severe COVID-19 requiring hospitalization (1, 2). The mechanism may encompass promotion of inflammation by facilitation of liver injury, which is a frequent feature of severe COVID-19 (3). However, metabolic dysfunction rather than FLD itself may induce disease progression (2). Indeed, we previously showed that a genetic FLD-risk score does not predispose to severe COVID-19 in UK Biobank population-based cohort (UKBB) (4).File | Dimensione | Formato | |
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