Adrenoceptors are ubiquitous and regulate heart and respiratory rate, digestion, metabolism, and vascular tone. They can be activated or blocked with adrenergic drugs, but systemic administration causes broad adverse effects. We have developed photochromic ligands (adrenoswitches) to switch on and off adrenoceptor activity on demand at selected locations. Their pharmacology, photochromism, bioavailability and lack of toxicity allow photomodulating adrenergic signalling, as demonstrated by controlling locomotion in zebrafish and pupillary responses in blind mice.

Adrenergic Modulation with Photochromic Ligands / D. Prischich, A.M.J. Gomila, S. Milla-Navarro, G. Sangüesa, R. Diez-Alarcia, B. Preda, C. Matera, M. Batlle, L. Ramírez, E. Giralt, J. Hernando, E. Guasch, J. Javier Meana, P. de la Villa, P. Gorostiza. - (2020 Apr 28). [10.26434/chemrxiv.12203066]

Adrenergic Modulation with Photochromic Ligands

C. Matera;
2020

Abstract

Adrenoceptors are ubiquitous and regulate heart and respiratory rate, digestion, metabolism, and vascular tone. They can be activated or blocked with adrenergic drugs, but systemic administration causes broad adverse effects. We have developed photochromic ligands (adrenoswitches) to switch on and off adrenoceptor activity on demand at selected locations. Their pharmacology, photochromism, bioavailability and lack of toxicity allow photomodulating adrenergic signalling, as demonstrated by controlling locomotion in zebrafish and pupillary responses in blind mice.
Settore CHIM/08 - Chimica Farmaceutica
28-apr-2020
https://chemrxiv.org/articles/preprint/Adrenergic_Modulation_with_Photochromic_Ligands/12203066/1
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/771940
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