The present intervention relates to new peptides that increase the activity of the enzyme ADAM10 by acting at various levels in the cascade of events that leads to the accumulation of the beta-amyloid peptide. Pharmaceutical compositions are also contemplated comprising activator peptides of the enzyme ADAM10 and the related uses in the medical field for the treatment and/or prevention of the pathologies wherein the increase or accumulation of the beta-amyloid peptide occurs, such as Alzheimer's Disease, head injury and post-traumatic stress disorder.

Peptidi attivatori dell'enzima ADAM10 e relativi usi nel trattamento delle patologie caratterizzate da un aumento del peptide β-amiloide / M. di luca, E. Marcello, D. di marino, S. Musardo, S. Therin, F. Gardoni.

Peptidi attivatori dell'enzima ADAM10 e relativi usi nel trattamento delle patologie caratterizzate da un aumento del peptide β-amiloide

M. di luca;E. Marcello;S. Musardo;S. Therin;F. Gardoni
2019

Abstract

The present intervention relates to new peptides that increase the activity of the enzyme ADAM10 by acting at various levels in the cascade of events that leads to the accumulation of the beta-amyloid peptide. Pharmaceutical compositions are also contemplated comprising activator peptides of the enzyme ADAM10 and the related uses in the medical field for the treatment and/or prevention of the pathologies wherein the increase or accumulation of the beta-amyloid peptide occurs, such as Alzheimer's Disease, head injury and post-traumatic stress disorder.
Università degli Studi di Milano
WO2019/123413
PCT/IB2018/060511
IT201700149130
27-giu-2019
Settore BIO/14 - Farmacologia
https://patentscope.wipo.int/search/de/detail.jsf;jsessionid=79C3DFAFAB8F4E582F73A5E5C1BB16FE.wapp1nA?docId=WO2019123413&recNum=5196&office=&queryString=&prevFilter=&sortOption=Veröffentlichungsdatum+ab&maxRec=75551179
Peptidi attivatori dell'enzima ADAM10 e relativi usi nel trattamento delle patologie caratterizzate da un aumento del peptide β-amiloide / M. di luca, E. Marcello, D. di marino, S. Musardo, S. Therin, F. Gardoni.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/747834
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact