The present intervention relates to new peptides that increase the activity of the enzyme ADAM10 by acting at various levels in the cascade of events that leads to the accumulation of the beta-amyloid peptide. Pharmaceutical compositions are also contemplated comprising activator peptides of the enzyme ADAM10 and the related uses in the medical field for the treatment and/or prevention of the pathologies wherein the increase or accumulation of the beta-amyloid peptide occurs, such as Alzheimer's Disease, head injury and post-traumatic stress disorder.
Peptidi attivatori dell'enzima ADAM10 e relativi usi nel trattamento delle patologie caratterizzate da un aumento del peptide β-amiloide / M. di luca, E. Marcello, D. di marino, S. Musardo, S. Therin, F. Gardoni.
Peptidi attivatori dell'enzima ADAM10 e relativi usi nel trattamento delle patologie caratterizzate da un aumento del peptide β-amiloide
M. di luca;E. Marcello;S. Musardo;S. Therin;F. Gardoni
2019
Abstract
The present intervention relates to new peptides that increase the activity of the enzyme ADAM10 by acting at various levels in the cascade of events that leads to the accumulation of the beta-amyloid peptide. Pharmaceutical compositions are also contemplated comprising activator peptides of the enzyme ADAM10 and the related uses in the medical field for the treatment and/or prevention of the pathologies wherein the increase or accumulation of the beta-amyloid peptide occurs, such as Alzheimer's Disease, head injury and post-traumatic stress disorder.Pubblicazioni consigliate
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