Chronic kidney disease is a condition in which parathyroid are affected by a combination of elevated extracellular phosphate concentration, decreased extracellular ionized calcium concentration, and markedly reduced serum calcitriol, leading to increased PTH synthesis and release. At early stages in the development of hyperparathyroidism, these changes are compounded of variable down-regulation of the calcium-sensing receptor (CaSR) and vitamin D receptor (VDR), making the parathyroid cells unable to respond appropriately to calcium and/or calcitriol. The resulting increase in proliferative activity in the parathyroid glands leads to parathyroid hyperplasia.

Parathyroid Glands in CKD: Anatomy, Histology, Physiology and Molecular Biology in CKD / M. Cozzolino, P. Monciino, M. Frittoli, F. Perna, E. Fasulo, R. Casazza, M. Fugakawa - In: Parathyroid Glands in Chronic Kidney Disease / [a cura di] A. Covic, D. Goldsmith, P.A. Ureña Torres. - [s.l] : Springer Nature, 2020 May. - ISBN 9783030437688. - pp. 1-19 [10.1007/978-3-030-43769-5_1]

Parathyroid Glands in CKD: Anatomy, Histology, Physiology and Molecular Biology in CKD

M. Cozzolino
Primo
;
P. Monciino
Secondo
;
M. Frittoli;F. Perna;E. Fasulo;R. Casazza
Penultimo
;
2020

Abstract

Chronic kidney disease is a condition in which parathyroid are affected by a combination of elevated extracellular phosphate concentration, decreased extracellular ionized calcium concentration, and markedly reduced serum calcitriol, leading to increased PTH synthesis and release. At early stages in the development of hyperparathyroidism, these changes are compounded of variable down-regulation of the calcium-sensing receptor (CaSR) and vitamin D receptor (VDR), making the parathyroid cells unable to respond appropriately to calcium and/or calcitriol. The resulting increase in proliferative activity in the parathyroid glands leads to parathyroid hyperplasia.
Chronic kidney disease; Secondary hyperparathyroidism; Parathyroid hormone; Vitamin D; Calcium; Phosphate
Settore MED/14 - Nefrologia
mag-2020
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/734358
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