[Ag(PcL)]-Catalyzed Domino Reactions of 2-Alkynylbenzaldehydes with Electron-poor Anilines: Synthesis of 1-Aminoisochromenes

In this paper, we describe the synthesis of neglected 1-aminoisochromene derivatives starting from 2-alkynylbenzaldehydes and electron-poor anilines. The domino reaction is catalyzed by original [Ag(I)PcL] complexes and occurs with complete regioselectivity under mild conditions. The approach well-tolerates different aryl, heteroaryl, alkyl and cycloalkyl substituents on alkyne terminus to give the desired products in modest to very good yields.