The implications of a tumor microenvironment in cancer initiation and progression have drawn interest in recent years. Within the tumor stroma, fibroblasts represent a predominant cell type and are responsible for the majority of extracellular components within the tumor microenvironment, such as matrix and soluble factors. A switch from quiescent fibroblasts to cancer-associated fibroblasts triggers a large variety of pro-tumorigenic signals that support tumor progression and shape the surrounding pathological stroma, with the remodeling of tissue architecture and repression of the local immune response. The heterogeneous nature of cancer-associated fibroblasts and their multiple functions are subject of active research as they could represent promising targets for cutting-edge therapeutic approaches to cancer and the tumor microenvironment.

Fibroblasts in the Tumor Microenvironment / M. Truffi, L. Sorrentino, F. Corsi (ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY). - In: Tumor Microenvironment : Non-Hematopoietic Cells / [a cura di] A. Birbrair. - [s.l] : Springer, 2020. - ISBN 9783030371838. - pp. 15-29

Fibroblasts in the Tumor Microenvironment

M. Truffi;L. Sorrentino;F. Corsi
2020

Abstract

The implications of a tumor microenvironment in cancer initiation and progression have drawn interest in recent years. Within the tumor stroma, fibroblasts represent a predominant cell type and are responsible for the majority of extracellular components within the tumor microenvironment, such as matrix and soluble factors. A switch from quiescent fibroblasts to cancer-associated fibroblasts triggers a large variety of pro-tumorigenic signals that support tumor progression and shape the surrounding pathological stroma, with the remodeling of tissue architecture and repression of the local immune response. The heterogeneous nature of cancer-associated fibroblasts and their multiple functions are subject of active research as they could represent promising targets for cutting-edge therapeutic approaches to cancer and the tumor microenvironment.
Cancer-associated fibroblasts; Epithelial-to-mesenchymal transition; Tumor microenvironment; Pro-tumorigenic cytokines; Extracellular matrix remodeling; Tumor neoangiogenesis Immunosuppression; Cancer-stroma crosstalk; Chemoresistance; Targeted therapy; Cancer treatment
Settore MED/18 - Chirurgia Generale
2020
Book Part (author)
File in questo prodotto:
File Dimensione Formato  
Truffi, Sorrentino, Corsi_.pdf

accesso riservato

Tipologia: Pre-print (manoscritto inviato all'editore)
Dimensione 816.59 kB
Formato Adobe PDF
816.59 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/716762
Citazioni
  • ???jsp.display-item.citation.pmc??? 24
  • Scopus 66
  • ???jsp.display-item.citation.isi??? 56
social impact