The implications of a tumor microenvironment in cancer initiation and progression have drawn interest in recent years. Within the tumor stroma, fibroblasts represent a predominant cell type and are responsible for the majority of extracellular components within the tumor microenvironment, such as matrix and soluble factors. A switch from quiescent fibroblasts to cancer-associated fibroblasts triggers a large variety of pro-tumorigenic signals that support tumor progression and shape the surrounding pathological stroma, with the remodeling of tissue architecture and repression of the local immune response. The heterogeneous nature of cancer-associated fibroblasts and their multiple functions are subject of active research as they could represent promising targets for cutting-edge therapeutic approaches to cancer and the tumor microenvironment.
|Titolo:||Fibroblasts in the Tumor Microenvironment|
|Parole Chiave:||Cancer-associated fibroblasts; Epithelial-to-mesenchymal transition; Tumor microenvironment; Pro-tumorigenic cytokines; Extracellular matrix remodeling; Tumor neoangiogenesis Immunosuppression; Cancer-stroma crosstalk; Chemoresistance; Targeted therapy; Cancer treatment|
|Settore Scientifico Disciplinare:||Settore MED/18 - Chirurgia Generale|
|Data di pubblicazione:||2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/978-3-030-37184-5_2|
|Tipologia:||Book Part (author)|
|Appare nelle tipologie:||03 - Contributo in volume|