Systemic lupus erythematosus (SLE) is a highly heterogeneous autoimmune disease characterised by the production of pathogenic autoantibodies against nuclear self-antigens. The anti-inflammatory and tolerogenic cytokine Interleukin-10 appears to play a paradoxical pathogenic role in SLE and is therefore currently therapeutically targeted in clinical trials. It is generally assumed that the pathogenic effect of IL-10 in SLE is due to its growth and differentiation factor activity on autoreactive B-cells, but effects on other cells might also play a role. To date, a unique cellular source of pathogenic IL-10 in SLE has not been identified. In this review, we focus on the contribution of different CD4+T-cell subsets to IL-10 and autoantibody production in SLE. In particular, we discuss that IL-10 produced by different subsets of adaptive regulatory T-cells, follicular helper T-cells and extra-follicular B-helper T-cells is likely to have different effects on autoreactive B-cell responses. A better understanding of the role of IL-10 in B-cell responses and lupus would allow to identify the most promising therapies for individual SLE patients in the future.

IL-10 producing regulatory and helper T-cells in systemic lupus erythematosus / J. Geginat, M. Vasco, M. Gerosa, S.W. Tas, M. Pagani, F. Grassi, R.A. Flavell, P. Meroni, S. Abrignani. - In: SEMINARS IN IMMUNOLOGY. - ISSN 1044-5323. - 44:Special Issue(2019 Aug). [10.1016/j.smim.2019.101330]

IL-10 producing regulatory and helper T-cells in systemic lupus erythematosus

J. Geginat
;
M. Gerosa;M. Pagani;F. Grassi;S. Abrignani
Ultimo
2019

Abstract

Systemic lupus erythematosus (SLE) is a highly heterogeneous autoimmune disease characterised by the production of pathogenic autoantibodies against nuclear self-antigens. The anti-inflammatory and tolerogenic cytokine Interleukin-10 appears to play a paradoxical pathogenic role in SLE and is therefore currently therapeutically targeted in clinical trials. It is generally assumed that the pathogenic effect of IL-10 in SLE is due to its growth and differentiation factor activity on autoreactive B-cells, but effects on other cells might also play a role. To date, a unique cellular source of pathogenic IL-10 in SLE has not been identified. In this review, we focus on the contribution of different CD4+T-cell subsets to IL-10 and autoantibody production in SLE. In particular, we discuss that IL-10 produced by different subsets of adaptive regulatory T-cells, follicular helper T-cells and extra-follicular B-helper T-cells is likely to have different effects on autoreactive B-cell responses. A better understanding of the role of IL-10 in B-cell responses and lupus would allow to identify the most promising therapies for individual SLE patients in the future.
English
Autoantibodies; CD4; +; T-cells; IL-10; Systemic lupus erythematosus
Settore BIO/11 - Biologia Molecolare
Review essay
Esperti anonimi
Pubblicazione scientifica
ago-2019
Elsevier : Academic Press
44
Special Issue
101330
9
Pubblicato
Periodico con rilevanza internazionale
scopus
pubmed
crossref
Aderisco
info:eu-repo/semantics/article
IL-10 producing regulatory and helper T-cells in systemic lupus erythematosus / J. Geginat, M. Vasco, M. Gerosa, S.W. Tas, M. Pagani, F. Grassi, R.A. Flavell, P. Meroni, S. Abrignani. - In: SEMINARS IN IMMUNOLOGY. - ISSN 1044-5323. - 44:Special Issue(2019 Aug). [10.1016/j.smim.2019.101330]
open
Prodotti della ricerca::01 - Articolo su periodico
9
262
Article (author)
no
J. Geginat, M. Vasco, M. Gerosa, S.W. Tas, M. Pagani, F. Grassi, R.A. Flavell, P. Meroni, S. Abrignani
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/696170
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