We present the first direct comparative evaluation of an antibody-drug conjugate and of a small molecule-drug conjugate for cancer therapy, using chemically defined products which bind with high-affinity to carbonic anhydrase IX, a marker of tumor hypoxia and of renal cell carcinoma.

Chemically defined antibody- and small molecule-drug conjugates for in vivo tumor targeting applications: A comparative analysis / S. Cazzamalli, A. Dal Corso, F. Widmayer, D. Neri. - In: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. - ISSN 0002-7863. - 140:5(2018 Feb 07), pp. 1617-1621. [10.1021/jacs.7b13361]

Chemically defined antibody- and small molecule-drug conjugates for in vivo tumor targeting applications: A comparative analysis

A. Dal Corso;
2018

Abstract

We present the first direct comparative evaluation of an antibody-drug conjugate and of a small molecule-drug conjugate for cancer therapy, using chemically defined products which bind with high-affinity to carbonic anhydrase IX, a marker of tumor hypoxia and of renal cell carcinoma.
Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Antineoplastic Agents; Carbonic Anhydrase IX; Carbonic Anhydrase Inhibitors; Carcinoma, Renal Cell; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Kidney Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Experimental; Small Molecule Libraries; Tumor Hypoxia
Settore CHIM/06 - Chimica Organica
Settore CHIM/08 - Chimica Farmaceutica
7-feb-2018
17-gen-2018
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/685891
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