We present the first direct comparative evaluation of an antibody-drug conjugate and of a small molecule-drug conjugate for cancer therapy, using chemically defined products which bind with high-affinity to carbonic anhydrase IX, a marker of tumor hypoxia and of renal cell carcinoma.
Chemically defined antibody- and small molecule-drug conjugates for in vivo tumor targeting applications: A comparative analysis / S. Cazzamalli, A. Dal Corso, F. Widmayer, D. Neri. - In: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. - ISSN 0002-7863. - 140:5(2018 Feb 07), pp. 1617-1621. [10.1021/jacs.7b13361]
Chemically defined antibody- and small molecule-drug conjugates for in vivo tumor targeting applications: A comparative analysis
A. Dal Corso;
2018
Abstract
We present the first direct comparative evaluation of an antibody-drug conjugate and of a small molecule-drug conjugate for cancer therapy, using chemically defined products which bind with high-affinity to carbonic anhydrase IX, a marker of tumor hypoxia and of renal cell carcinoma.File in questo prodotto:
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